James D. Watson

"The tendency is to focus on the worst-case scenario and to shy away from potentially controversial science; it is time, I think, we looked instead at the benefits."

"Ideology—of any kind—and science are at best inappropriate bedfellows. Science may indeed uncover unpleasant truths, but the critical thing is that they are truths. Any effort, whether wicked or well-meaning, to conceal truth or impede its disclosure is destructive. Too often in our free society, scientists willing to take on questions with political ramifications have been made to pay an unjust price."

"Murray and Herrnstein’s assertion, however, was that the discrepancy was so great that environment likely couldn’t explain it all. Similarly, environmental factors alone may not account for why, globally, Asians have on average higher IQs than other racial groups. The idea of measurable variations in average intelligence among ethnic groups is not one, I admit, I want to live with. But though The Bell Curve’s claims remain questionable, we should not allow political anxieties to keep us from looking into them further."

"The finding that there is a substantial genetic component to our behavior should not surprise us; indeed, it would be far more surprising if this were not the case. We are products of evolution: among our ancestors, natural selection indubitably exerted a strong influence over all traits that have figured in our survival."

"The future promises a detailed genetic dissection of personality, and it is hard to imagine that what we discover will not tip the scales of the nature/nurture debate more and more in the direction of nature—a frightening thought for some, but only if we persist in being held hostage by a static, ultimately meaningless dichotomy. To find that any trait, even one with formidable political implications, has a mainly genetic basis is not to find something set immutably in stone. It is merely to understand the nature upon which nurture is ever acting, and those things we, as a society and as individuals, need to do if we are better to assist the process. Let us not allow transient political considerations to set the scientific agenda. Yes, we may uncover truths that make us uneasy in the light of our present circumstances, but it is those circumstances, not nature’s truth, to which policy makers ought to address themselves."

"Life, we now know, is nothing but a vast array of coordinated chemical reactions. The “secret” to that coordination is the breathtakingly complex set of instructions inscribed—again, chemically—in our DNA."

"If, therefore, we are serious about improving education, we cannot in good conscience ultimately limit ourselves to seeking remedies in nurture. My suspicion, however, is that education policies are too often set by politicians to whom the glib slogan “Leave no child behind” appeals precisely because it is so completely unobjectionable. But children will get left behind if we continue to insist that each one has the same potential for learning."

"The issue, rather, is this: Are we prepared to embrace the undeniably vast potential of genetics to improve the human condition, individually and collectively? Most immediate, would we want the guidance of genetic information to design learning best suited to our children’s individual needs?"

"The reality is that the idea of improving on the genes that nature has given us alarms people. When discussing our genes, we seem ready to commit what philosophers call the naturalistic fallacy, assuming that the way nature intended it is best. By centrally heating our homes and taking antibiotics when we have an infection, we carefully steer clear of the fallacy in our daily lives, but mentions of genetic improvement have us rushing to run the “nature knows best” flag up the mast. For this reason, I think that the acceptance of genetic enhancement will most likely come about through efforts to prevent disease."

"I find such a moralistic response to be profoundly immoral."

"But even if we allow hypothetically that gene enhancement could—like any powerful technology—be applied to nefarious social ends, that only strengthens the case for our developing it. Considering the near impossibility of repressing technological progress, and the fact that much of what is now prohibited is well on its way to becoming practicable, do we dare restrain our own research community and risk allowing some culture that does not share our values to gain the upper hand? From the time the first of our ancestors fashioned a stick into a spear, the outcomes of conflicts throughout history have been dictated by technology."

"And so if there is a paramount ethical issue attending the vast new genetic knowledge created by the Human Genome Project, in my view it is the slow pace at which what we now know is being deployed to diminish human suffering. Leaving aside the uncertainties of gene therapy, I find the lag in embracing even the most unambiguous benefits to be utterly unconscionable. That in our medically advanced society almost no women are screened for the fragile X mutation two decades after its discovery can attest only to ignorance or intransigence."

"I do not dispute the right of individuals to look to religion for a private moral compass, but I do object to the assumption of too many religious people that atheists live in a moral vacuum. Those of us who feel no need for a moral code written down in an ancient tome have, in my opinion, recourse to an innate moral intuition long ago shaped by natural selection promoting social cohesion in groups of our ancestors."

"With its direct contradiction of religious accounts of creation, evolution represents science’s most direct incursion into the religious domain and accordingly provokes the acute defensiveness that characterizes creationism."

"There is in the first place its scientific interest. The discovery of the structure by Crick and Watson, with all its biological implications, has been one of the major scientific events of this century. The number of researches which it has inspired is amazing; it has caused an explosion in biochemistry which has transformed the science. I have been amongst those who have pressed the author to write his recollections while they are still fresh in his mind, knowing how important they would be as a contribution to the history of science. The result has exceeded expectation. The latter chapters, in which the birth of the new idea is described so vividly, are drama of the highest order; the tension mounts and mounts towards the final climax. I do not know of any other instance where one is able to share so intimately in the researcher's struggles and doubts and final triumph. Then again, the story is a poignant example of a dilemma which may confront an investigator. He knows that a colleague has been working for years on a problem and has accumulated a mass of hard-won evidence, which has not yet been published because it is anticipated that success is just around the comer. He has seen this evidence and has good reason to believe that a method of attack which he can envisage, perhaps merely a new point of view, will lead straight to the solution. An offer of collaboration at such a stage might well be regarded as a trespass. Should he go ahead on his own It is not easy to be sure whether the crucial new idea is really one's own or has been unconsciously assimilated in talks with others. The realization of this difficulty has led to the establishment of a some what vague code amongst scientists which recognizes a claim in a line of research staked out by a colleague up to a certain point. When competition comes from more than one quarter, there is no need to hold back. This dilemma comes out clearly in the DNA story. It is a source of deep satisfaction to all intimately concerned that, in the award of the Nobel Prize in 1962, due recognition was given to the long, patient investigation by Wilkins at King's College (London) as well as to the brilliant and rapid final solution by Crick and Watson at Cambridge. Finally, there is the human interest of the story the impression made by Europe and by England in particular upon a young man from the States. He writes with a Pepys like frankness. Those who figure in the book must read it in a very forgiving spirit. One must remember that his book is not a history, but an autobiographical contribution to the history which will some day be written. As the author himself says, the book is a record of impressions rather than historical facts. The issues were often more complex, and the motives of those who had to deal with them were less tortuous, than he realized at the time. On the other hand, one must admit that his intuitive understanding of human frailty often strikes home."

"He says that he is “inherently gloomy about the prospect of Africa” because “all our social policies are based on the fact that their intelligence is the same as ours – whereas all the testing says not really”, and I know that this “hot potato” is going to be difficult to address. His hope is that everyone is equal, but he counters that “people who have to deal with black employees find this not true”. He says that you should not discriminate on the basis of colour, because “there are many people of colour who are very talented, but don’t promote them when they haven’t succeeded at the lower level”. He writes that “there is no firm reason to anticipate that the intellectual capacities of peoples geographically separated in their evolution should prove to have evolved identically. Our wanting to reserve equal powers of reason as some universal heritage of humanity will not be enough to make it so”."

"Consistently rated as one of the greatest books written about science in the past century, it has been hailed as a work that combines the plot line of a racy novel with deep insights about the nature of modern research. But James Watson, author of The Double Helix, has revealed that his masterpiece came close to being suppressed. In an exclusive interview with the Observer, he admitted last week that his account of the discovery of the structure of DNA, when shown to friends and colleagues in the late 60s, triggered such hostility and outrage it seemed fated never to appear in print. … Many publishers were frightened off by threats of legal action from the manuscript's critics. Watson's depictions of several scientists were deeply unflattering and the book's secondary plot, which focuses on Watson's pursuit of young women – or "popsies" as he called them – around Cambridge, was considered irrelevant and patronising. Harvard University Press, having accepted Watson's manuscript for publication, came under pressure from the university's senior administrators and dropped the book. It took the intervention of Lady Alice Bragg, the wife of Watson's former boss, Sir [William] Lawrence Bragg, to save The Double Helix, Watson has revealed."

"The Double Helix opens with the words: "I have never seen Francis Crick in a modest mood." I have never seen James D Watson in a modest mood, either. He is not an innately modest person. In his later years he would consent to press briefings – usually on important anniversaries – and then, with long pauses and enigmatic mumbles, say almost nothing. This was not because he was self-effacing or disliked controversy. He would say almost nothing, one sensed, because he couldn't be bothered with stupid questions from stupid people. He has made it clear more than once that this is his default attitude."