"Parkinson’s disease primarily affects the central nervous system, but autopsy and small patient studies have revealed autonomic nervous system pathology in most cases. We looked for α-synuclein pathology in routinely acquired biopsies from patients and matched controls. Immunocytochemistry was performed and assessed blind to the clinical diagnoses. ... This large scale study demonstrates that accumulation of α-synuclein in the gastrointestinal tract is a highly specific finding that could be used to confirm a clinical diagnosis of Parkinson’s disease. We have shown that α-synuclein accumulation occurs prior to the onset of motor symptoms in the upper, as well as the lower gastrointestinal tract, remains present in serial biopsies until the onset of motor symptoms and is predominantly composed of phosphorylated α-synuclein."
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Original Language: English
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David Hilton, Madeleine Stephens, Leanne Kirk, Philip Edwards, Ross Potter, John Zajicek, Ellie Broughton, Hannah Hagan, and Camille Carroll
https://en.wikiquote.org/wiki/Parkinson's_disease
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Parkinson's disease
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