"Four recent developments in reaction methodology—two of them being organocatalytic reactions—now allow for a very efficient access to UCS1025A. (...) We have developed a straightforward strategy for the synthesis of an important class of lepidopteran sex pheromones starting from simple dialdehydes. The combination of a Wittig reaction and an organocatalytic reduction represents a useful sequence for the nontrivial two-carbon homologation of aldehydes. (...) In the early stages of the UCS1025A campaign, we developed a novel two-step approach to small N-heterocycles using an organocatalytic Mannich reaction and a novel CDI-mediated dehydrative cyclization. (...) Our work and that of others have clearly demonstrated that organocatalytic strategies can cut down the total number of synthetic operations."
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Original Language: English
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D. Enders, M. R. M. Hüttl, and O. Niemeier. "Biomimetic organocatalytic C–C-bond formations." in Organocatalysis (2008) edited by M.T. Reetz, B. List, S. Jaroch, H. Weinmann.
https://en.wikiquote.org/wiki/Organocatalysis
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Organocatalysis
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