Chemists From England

"If the present volume will help towards the comprehension of the fundamental principles on which the science of thermodynamics rests, and also serve to bring home the importance of a knowledge of these principles in the suggestion and interpretation of experimental work, the purpose which has been kept in view during its preparation will have been amply fulfilled. In any case, it is hoped that neither the extreme view that thermodynamic principles alone suffice in the construction of a systematic physical or chemical science, nor the equally mistaken opinion that they are of little practical utility to the experimental worker, can fairly result from its study."

"The statement of a law of nature involves the formation of a concept, or general idea, in which the likenesses of phenomena are collected, and the differences, in so far as they are not intimately involved in the nature of the case, are eliminated."

"From the time when Guldberg and Waage gave quantitative form to the speculations of the physicist Berthollet, a clear conception of chemical equilibrium, in sharp contrast to an anthropomorphic theory of affinity dating back to Hippocrates and Barchausen, has yielded rich and abundant fruit."

"To a person whose experience has never been brought into relation with the object sulphur, the name signifies nothing; to the scientist... his concept involves the ideas of specific gravity, crystalline form, element, atom, and the like, derived from past experiences. His concept is distinguished from the other by involving... number or quantity."

"The earliest applications of chemical processes were concerned with the extraction and working of metals and the manufacture of pottery. ...The irruption of an iron using race or races into Mediterranean sites ...introduced the Iron Age... but many of the oldest arts still survived in almost their original form. The potter, for example, still used nearly the same materials and appliances as Neolithic man."

"Side by side with the production of metals, the Egyptians and the inhabitants of Mesopotamia perfected the arts of making glazed pottery... and the production of glass. ...vessels were baked in tall closed furnaces. "Egyptian blue" was made in Egypt by heating silica with malachite and lime... applied with soda as a blue glaze on faience, and the blue glass is also colored with copper. Some early... Egyptian and Babylonian blue glass are coloured with cobalt."

"The philosopher Comte has made the statement that chemistry is a non-mathematical science. He also told us that astronomy had reached a stage when further progress was impossible. These remarks, coming after Dalton's atomic theory, and just before Guldberg and Waage were to lay the foundations of chemical dynamics, Kirchhoff to discover the reversal of lines in the solar spectrum, serve but to emphasize the folly of having "recourse to farfetched and abstracted Ratiocination," and should teach us to be "very far from the litigious humour of loving to wrangle about words or terms or notions as empty"."

"It was a great achievement of the early chemists — with the crude experimental techniques available also with the ever-astonishing power of human reason (as potent then as now) — to discover this reduction of the world to its components, the chemical elements. Such reduction does not destroy its charm but adds understanding to sensation, and this understanding only deepens our delight."

"This is the kingdom of the chemical elements, the substances from which everything tangible is made. It is not an extensive country, for it consists of only a hundred or so regions (as we shall often term the elements), yet it accounts for everything material in our actual world. From the hundred elements that are at the center of our story, all planets, rocks, vegetation, and animals are made. These elements are the basis of the air, the oceans, and the Earth itself. We stand on the elements, we eat the elements, we are the elements. Because our brains are made up of elements, even our opinions are, in a sense, properties of the elements and hence inhabitants of the kingdom."

"I have presented the periodic table as a kind of travel guide to an imaginary country, of which the elements are the various regions. This kingdom has a geography: the elements lie in particular juxtaposition to one another, and they are used to produce goods, much as a prairie produces wheat and a lake produces fish. It also has a history. Indeed, it has three kinds of history: the elements were discovered much as the lands of the world were discovered; the kingdom was mapped, just as the world was mapped, and the relative positions of the elements came to take on a great significance; and the elements have their own cosmic history, which can be traced back to the stars."

"The kingdom is not an amorphous jumble of regions, but a closely organized state in which the character of one region is close to that of its neighbor. There are few sharp boundaries. Rather, the landscape is largely characterized by transitions ..."

"The general disposition of the land is one of metals in the west, giving way, as you travel eastward, to a varied landscape of nonmetals, which terminates in largely inert elements at the eastern shoreline. To the south of the mainland, there is an offshore island, which we shall call the Southern Island. It consists entirely of metals of subtly modulated personality. North of the mainland, situated rather like Iceland off the northwestern edge of Europe, lies a single, isolated region-hydrogen. This simple but gifted element is an essential outpost of the kingdom, for despite its simplicity it is rich in chemical personality. It is also the most abundant element in the universe and the fuel of the stars."

"Chemistry is the science of matter and the changes it can undergo. The world of chemistry therefore embraces everything material around us—the stones we stand on, the food we eat, the flesh we are made of, and the silicon we build into computers. There is nothing material beyond the reach of chemistry, be it living or dead, vegetable or mineral, on Earth or in a distant star."

"This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work."

"It is fairly clear that American with recent foreign roots are overrepresented in any classification of Americans who have brought honour and recognition to the United States"

"It’s an absolutely good thing. I can think of one even better thing for young people, especially in India. It shows them you can study in India, get your basic education in India and you can (then) do whatever you want after that. That’s a very important message."

"My own lab has two Chinese, a Malaysian, a Canadian, an American, a German, it has had all sorts of people. And it’s actually fun because people from different countries come together, they have cultural exchanges, they learn more about each others’ countries and way of life. Science is a great international mixer, so the idea that it is a sort of cricket match where our team won — that simply is a wrong way of looking at scientific discovery."

"Indians tend to be a little insecure and they should stop being insecure — I have visited India many times and I can tell you questions I get after my talks are as perceptive as anywhere else in the world, including places like Harvard or MIT. It’s perfectly fine to take pride that someone from their region has used their background and succeeded. That gives them a positive message that they can do anything that they want."

"The ribosome does amazing chemistry, but I’m not a chemist…I’ve just learnt enough to work on my problem."

"That is the wrong question to ask…You can’t go into science thinking of a Nobel Prize. You can only go into science because you’re interested in it."

"It’s not about where you were born, or where you come from that makes you a good scientist. What you need are good teachers, co-students, facilities, [he said]. I honestly don’t think my roots have much to do with it. I’m sure this won’t make me popular, but this is what I think."

"Now many excellent scientists in India are doing really first rate work and it should not matter when the next Indian Nobel Prize is because they are doing very good work — that is what matters and the more you have this infrastructure, with good scientists within India, eventually someone will get a Nobel Prize for work done within India."

"This reconnection...has given me great satisfaction. I realise I have inadvertently become a source of inspiration and hope for people in India simply by the fact that I grew up there, went to my local university, but could go on to do well internationally. The Nobel, he says, is not just an affirmation of his past work; it’s an encouragement to keep working on interesting problems."

"Many in my family were ambivalent about it, but my mother encouraged me to put aside my fears. Vera (my wife) and I finally decided to leave Utah, where we were very happy, take a 40 per cent salary cut and move to the Laboratory of Molecular Biology at Cambridge."

"Last year, the lecture was held in [an auditorium] with a capacity for just 300 people, and half the seats were empty. “What has changed? I am still the same person doing the same science. Why are people so impressed when some academy in Sweden gives an award?"

"People go into science out of curiosity, not to win awards. But scientists are human and have ambitions. Even the best scientists are often insecure and feel the need for recognition."

"No. Geeks make huge advances in society. Newton was the ultimate geek. It should be a compliment."

"A life of science struck me as being both interesting and international in character."

"Dr. Ramakrishnan addressing an audience of 3,000 at the university’s Centenary Auditorium."

"There are already people who are world class in India, for example C.N.R. Rao (who has worked mainly in solid-state and structural chemistry). He is an example of how you can do first rate international work within India. So I would say to Indians — you have it within you to do this (in India)."

"You would have to ask a physicist really but I think understanding fundamental problems in physics is very important because they are part of our culture. You just never know what is going to come from it. If you had told Isaac Newton about spaceships and satellites that arise from his laws of gravity, it would have been science fiction to him."

"If I had complained about the prize before I got mine, they may have thought I was anticipating sour grapes. But I complained on the grounds that too many important scientists get missed out for Nobels. Science today is a highly collaborative exercise and to convert it into a contest, as the Nobel does, is a bad way to look at science. On the other hand, I am grateful to the committee for my award. It put the study of ribosome – the cellular machine that turns the blueprint of life into life itself – on front pages round the world."

"Find out what really fascinates you and follow that. Almost anything in nature, if you follow it, you will find a scientific problem. That is a better way to do it than following fads, because what is fashionable today may have been solved or fallen out of fashion once you have become a working scientist."

"I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it."

"I then got a PhD in physics [from Ohio University] though it was hatt hatt and hatt not a very good one."

"It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years. Or your approach may be fatally flawed and doomed to fail. Or you could get scooped just as you are finalising your work. It is very stressful."

"Scientists are trained to be rational and we are not trained to interact with people and develop social skills. Politics is about being able to convince people. Scientists could do with learning how to do that."

"I think it is the ability to tackle difficult problems in a sort of stable and supportive environment. I think that is the real key to it."

"Indeed, many of the founding members of the Laboratory of Molecular Biology were immigrants themselves, and they helped to revolutionise modern biology.""

"I was quite insistent. We have quite a few pranksters in the lab and I thought this was one of them. I even congratulated the man, ironically, on his Swedish accent."

"I knew the ribosome was going to be the focus of Nobel prizes. It stands at the crossroads of biology, between the gene and what comes out of the gene. But I had convinced myself I was not going to be a winner."

"In the current debate about immigration, it is worth noting that this award is yet another example of the numerous contributions that immigrants make to British society."

"Scientists work by a combination of intuition and insight in trying to understand a question."

"Fundamental information about the workings of the cellular machinery at the atomic level and is already being exploited by pharmaceutical companies to make new, more effective antibiotics"

"Another immense service rendered by Dalton, as a corollary of the new atomic doctrine, was the creation of a system of symbolic notation, which not only made the nature of chemical compounds and processes easily intelligible and easy of recollection, but, by its very form, suggested new lines of inquiry. The atomic notation was as serviceable to chemistry as the binomial nomenclature and the classificatory schematism of Linnæus were to zoölogy and botany."

"The most extraordinary man I met [in Manchester] is John Dalton, whose name is better known in almost any country of Europe than his own, and in any town than in Manchester. He is generally styled by continental writers the Father of Modern Chemistry, and is one of the eight associates of the Institute. Yet this man between sixty and seventy is earning, as I had a peculiar satisfaction in seeing with my own eyes, a penurious existence by teaching boys the elements of mathematics, with which he is so totally occupied, that he can hardly snatch a moment for the prosecution of discoveries which have already put his name on a level with the courtly and courted Davy. But the remarkable thing is that this simple and firm-minded man preserves all the original simplicity and equanimity of his mind, and calmly leaves his fame, like Bacon, to other nations and future ages.'"

"The conviction that chemical substances combine according to fixed and simple proportions gained ground on the Continent, chiefly during the discussion in which Proust finally disproved and defeated Berthollet's theory of chemical affinity; but it is to Dalton that the doctrine of fixed and multiple proportions is indebted for a consistent exposition. Dalton based it upon a mental representation which ever since has been the soul of all chemical reasoning."

"Dalton's records, carefully preserved for a century, were destroyed during the World War II bombing of Manchester. It is not only the living who are killed in war."

"From the hour he came from his mother's womb, the God of Nature had laid his hand upon his head, and had ordained him for the ministration of high philosophy. But his natural talents, great as they were, and his almost intuitive skill in tracing the relations of material phaenomena, would have been of comparatively little value to himself and to society, had there not been superadded to them a beautiful moral simplicity and singleness of heart, which made him go on steadily in the way he was before him, without turning to right hand or to the left, and taught him to do homage to no authority before that of truth."

"Chemical analysis and synthesis go no farther than to the separation of particles one from another, and to their reunion. No new creation or destruction of matter is within the reach of chemical agency. We might as well attempt to introduce a new planet into the solar system, or to annihilate one already in existence, as to create or destroy a particle of hydrogen. All the changes we can produce, consist in separating particles that are in a state of cohesion or combination, and joining those that were previously at a distance."