2020s American Sitcoms

"Jacob Vargas as Javier"

"Erik Griffin as Don, Mayan's Ex-Godfather"

"Melissa Fumero as Natalia"

"Rita Moreno as Dolores Lopez, George's Grandma"

"Antonio Raul Corbo - Carlos"

"Kareem Abdul-Jabbar - himself"

"Kensie Mills as Paloma"

"Chelsea Rendon as Luna"

"Marsha Warfield - Roz"

"Jessica Marie Garcia as Yesika"

"Harvey Guillen as Miguel"

"Jesus Zapien as Mr. Reyes"

"Luis Armand Garcia as Louie"

"Michelle Ortiz as Mrs. Garcia"

"Noelle the Rescue Dog as Churro, The Family Dog"

"Pam Murphy - Pam"

"Belita Moreno as Bella"

"Neil Flynn as Steve"

"Brice Gonzalez as Chance Lopez, George's grandson and Mayan's and Quinten's son"

"Melissa Villaseñor - Gabby"

"Constance Marie as Connie"

"Maria Bamford - The Ghost of Christmas Present"

"Brian Scolaro - Arnold"

"Matt Shively as Quinten Van Bryan, Mayan's Boyfriend"

"Valente Rodriguez as Val"

"Eden Sher as June"

"Snoop Dogg as Calvin, George's New Sponser"

"Jerry Garcia as Mando"

"John Gemberling - Bryant"

"Adam Kulbersh as Jerry"

"Jackie Hoffman - Linda"

"Moises Chavez as Raul (Guest Star: Season 1, Recurring: Season 2)"

"Tara Lipinski and Johnny Weir - themselves"

"Maria Canals-Barrera as Lily' Rosie's Sister"

"Momo Rodriguez as Momo, one of George's employees"

"Cheech Marin as Carlos (Guest Star: Season 1, Recurring: Season 2)"

"Faith Ford - Gina"

"Ana Rey as Flor, Rosie's Sister"

"Kurt Fuller - Jeff DeWitt"

"George Lopez as George"

"Mayim Bialik - Herself"

"Melissa Rauch - Abby Stone"

"India de Beaufort - Olivia (seasons 1–2)"

"Wendie Malick - Julianne (season 3)"

"Kapil Talwalkar - Neil (season 1)"

"Lacretta - Donna "Gurgs" Gurganous"

"John Larroquette - Dan Fielding"

"Nyambi Nyambi - Wyatt Shaw (seasons 2–3)"

"Pete Holmes - Rand"

"Jaime Camil as Josue Consuelos (Season 2)"