University Of Cambridge Faculty

"I shall... give an Account of what has been formerly attempted for making Sea-Water drinkable, especially what was done by Mr. Walcot and Mr. Fitz-gerald in King Charles the Second's Time."

"St. Basil, in his Homilies, says that when Men were cast on an Island, where there was no fresh Water; and they boiled Sea-Water; and catched the Vapour with Sponges, which they squeezed into another Boiler; and having passed thus, four or five Times from Boilers thro' Sponges, it became drinkable. This tedious way was used before the method of Disttiling was known, which was an Invention of the Arabs."

"About the Year 1675, William Walcot, Brother to Sir , obtained a Patent for making Sea-Water fresh: And the King, before the Grant of this Patent, had the curiosity to go and see Mr. Walcot do it, which was by distilling it in a very large Still; into the Still he put some Ingredient, which was to cure the distilled Water of any noxious Quality: But what it was, he kept a great secret. I suspect that the principal thing was only Distillation, because in all his printed Accounts of it, he purposely avoids the calling it a Still, but calls it a Machine or Engine, and Distilling he calls the working of the Machine, not Distilling."

"The Reverend Dr. Colbatch... who some Years since desired me to attempt, to make Sea-Water wholesome, informs me that he had good Reason to believe that the Ingredient which Mr. Walcot put into Sea-Water, in order to make it wholesome, was some Preparation of by Fire."

"[It] is evident, not only from considering the Effects of the Engine, which exchanges great Quantities of bad, for good Air; but also from the Event it having been found very salutary by the Swedes who have made the Trial."

"[T]he first important conception to be grasped by the student is that of the blood pressure, and the first experiment is designed to demonstrate its existence and to estimate its amount. ...It consists in connecting the of a dog to a long glass tube. Into this tube the blood mounts up and up to a height of five or six feet and then oscillates up or down with each contraction or relaxation of the heart. Such a tube... is called... the "Hales manometer" after its inventor... Dr. Hales."

"Hales was also a student of astronomy and constructed a brass machine for demonstrating the movements of the planets, and of this Stukeley made a sketch."

"In 1739 he published an volume entitled: "Philosophical experiments: containing useful and necessary instructions for such as undertake long Voyages at Sea..." This work, which contained so many useful instructions for voyagers, was dedicated to the Lords of the Admiralty."

"The methods devised by Hales and Triewald seem to have been identical, and the history of their invention is told by Hales in his book on ventilators published in 1743."

"The work and writings of Hales embrace a very broad field, which includes chemistry, botany, , medicine and public hygiene, not to mention sermons and temperance tracts."

"It is hoped, that the Light given by these Researches, may be of use in skilful Hands, for regulating and adapting the due Proportions of the acid, and the oily Principles, to different Cases and Constitutions. This is the proper Province of the Physician, which I am no ways qualified to meddle in."

"But whereas in some Cases, it is observed by Physicians to be too inflammatory, it is probable, that heating Quality, may in some Degree be abated, by making Tar-Water with the Strainer... without Stirring; thereby to divest the Water of a good Quantity of its grosser, tarrish Particles, and yet retain whatever Powers it may have to do good."

"Man, not contented with the Liquors, which his bountiful Creator intending for his Comfort, has wisely tempered with such a due Proportion of Strength, as would (if taken in Moderation,) make his Heart glad, has unhappily found Means to extract, from what God provided for his Refreshment, a most intoxicating and baneful Spirit, to which, in a great measure, is owing the remarkable Increase of Drunkenness of late Years; which Vice reigns to a most enormous Degree, among the habitual Drinkers of Gin, Brandy, and other Distilled Liquors; which are found to be most pernicious and destructive. For at the same shat they coagulate and thicken the Blood, they also contract and narrow the Blood-Vesels; which has, in fact, been found to be true, by Experiments I have purposely made with Brandy, on the Blood and Blood-Vesels of Animals."

"This Acid in Tar-water will curdle Milk; yet Turpentine-water will not... which shows that Tar is considerably acidulated, by the action of Fire in making."

"When Tar-waters of different Degrees of Strength were put into Florence Flasks, with other inverted Flasks fixed on them, and all were placed in the same Vessel of hot Water; on breaking the upper Flasks, the volatile acid Spirit could very sensibly be tasted, especially that of the stronger Tar-water; which shows that these Waters are impregnated therewith: and which when distilled from Turpentine, Dr. Boerhaave in his Chemistry says, is the best vegetable Acid that is known."

"We have seen in the Course of these Experiments, the Quantity of Tar that there is in Tar-Water; and the great Difference of that Quantity, made with different kinds of Tar, and different Degrees of Stirring. Now, since, notwithstanding these Quantities of Tar, and the additional more subtile volatile Oil, which flies off in Evaporation, it has yet undoubtedly proved an efficacious Remedy in many Cases and Instances; it may hence be reasonably concluded, that the Medicinal Virtue of the Water does not reside solely in the Acid, but partly also in the unctuous oily Parts, which are so temper'd by the Acid, as in some Cases to prevent their heating too much."

"Whence we may evidently see the Reason why those Liquors do so frequently cause those Obstructions and Stoppages in the Liver; which occasion the Jaundice, Dropsy, and many other fatal Diseases."

"Upon Inquiry from knowing Persons, I find that Norway or Swedish Tar, which is dark, thick and clear... is accounted the best for the general Uses... But that the Tar which is made of the Tops of -Trees... having lain long dead... after having either fallen... or being killed by the draining off their Sap... (These Tops are commonly called Light-wood, the poorer People making use of them instead of Candles:) This Tar being burned in a very strong Fire of such dry Wood, is of a very caustick, corroding Nature, so as to be hurtful to Ropes, &c. for which reason it is not used in the Royal Navy. But the American Tar, which is made of green Fir-Trees, with a less degree of Fire, is esteemed good, and is called green Tar..."

"Having procured some Norway or Swedish Tar which was thirty Years old... I, according to the Bishop's Prescription, made Tar-water in the proportion of a Gallon of Water to a Quart of Tar, stirring it four Minutes: I then took a Pint of this Tar-water, and evaporated it away in a , cut to a wide Orifice... and weighed."

"It is in like manner also that they destroy and burn up the Lungs. Hence also it is, that by frequently contracting and shrivelling, and then soon after relaxing, they weaken and wear out the Substance and Coats of the Stomach, on which they more immediately prey, every time they are drank."

"Hence likewise it is, that these spirituous Liquors rarely fail to destroy the Appetite and Digestion of those, who habituate themselves to them; for by drying up, and spoiling the Nerves, they make them insensible; they destroy also many of the very fine Blood Vessels, especially where their Fibres are most tender, as in the Brain; by which means, the Memory and intellectual Faculties are ruined: Nay, by inflaming the Blood, and disordering the Blood-Vessels and Nerves, they vitiate and deprave the Natural Temper."

"As the celebrated Tar-water, recommended by the worthy and learned Bishop Berkeley, is said to be taken with great Benefit by some, and Detriment by others; I thought it might probably be of use to inquire whether any, or what Quantity of Tar, there was in Tar-water, made with different kinds of Tar, different Degrees of stirring, and in different Ways of making it. A short Account of which I shall give, without interesting myself, either in Favour or Disfavour of a Medicine that is under the Inspection of the proper Judges, as well as of all the rest of the World."

"As these Ventilators are like to prove of great Benefit to Mankind, in many other Respects than are here mentioned, or can as yet be thought of; so it will be of great use, if those who shall have made farther Improvements, will... communicate them; as also an Account of the Difficulties or Success they have met with in putting the Things here proposed in execution."

"Could anything increase the pleasure I have in a literary intercourse with you, it would be to find that it answered your end in promoting the publick good. ... It does honour to those noble and other worthy personages that join you in acts of such extensive humanity as the introduction of ventilators into hospitals, prisons, ships of war, and transports, &c. as they must necessarily render the miseries of the first more supportable, and the close and constant confinement of the others less prejudicial and fatal to their health and life. It is to be lamented, that they are not more generally made use of... Those of your invention which I had were of singular service to us; they kept the inside of the ship cool, sweet, dry, and healthy: The number of slaves which I buried was very inconsiderable, and not one white man of our crew (which was thirty four) during a voyage of fifteen months; an instance very uncommon. The 340 negroes were very sensible of the benefits of a constant ventilation, and were always displeased when it was omitted. Even the exercise had an advantage not to be despised among people so much confined. ...Could I but see the immoderate use of spirituous liquors less general, and the benefit of ventilators more known and experienced, I might then hope to see mankind better and happier."

"This Treatise, he says, was read before the Royal Academy of Sweden the third day of April 1742. ...This was eleven Months after mine was laid before the Royal Society."

"And in his Letter to Baron Wasenberg, Envoy from the King of Sweden, dated the 22d of April 1743... he says, "that every Swedish Man of War, and Hospital Ship, was last Year furnished with one of my Engines; which had not been done, in case so they had not experienced the Benefit of the same, the Campaign so before that." So that a Trial was made with these Ventilators in the Year 1741, which proved a very sickly Summer in the Swedish Fleet, except only in the Ship or Ships, which were refreshed by Ventilators: A strong Instance of their great Usefulness; which induced the Swedes to put them into every Man of War and Hospital-Ship, the rear following."

"For this Engine [] had a Privilege for Life granted him by the King and Senate of Sweden, dated the 20th October 1741..."

"Being informed, while this Book was printing, that it was said that M.D. F.R.S. had long since made a like Proposal, for sweetning the Air of Ships, in a Treatise called Aëro-Chalinos, or a Register for the Air, printed in the Year 1677... In which Book is the following Proposal, viz. In order to have the Benefit of Change of Air, to another Country or Climate, almost at any Season, and that without going out of the House; he would have a Room, which he calls an Air-Chamber, to be built... Air-tight every where; with a very large Pair of Organ-Bellows to be placed in the Room; to or from which, Air is to be conveyed through the Wall, by a Copper Pipe; with Valves to open inward or outward as Occasion shall require. With these Bellows, the Air in the Room is either to be condensed and made heavier, by forcing Air in, or lighter, by conveying Air out of the Room."

"And Mr. Triewald further says, that in the Summer of the Year 1742, be bad sent one of his Engines, calculated for a Sixty Gun Man of War, to France; which being approved of by the Royal Academy of Sciences at Paris, the King of France has ordered all the Men of War to be furnished with the like Ventilators."

"He proposes by this means to cure intermitting Fevers, by having the Air in the Room rarefied in the cold Fit, and condensed in the hot Fit; during the whole time of which, the Patient is to continue therein: And recommends the use of it, among other Distempers, to cure the Stone and the Pox."

"We have here an Instance, that the Study of is not a meer trifling Amusement... For it not only delights the Mind, and gives it the most agreeable Entertainment, in seeing in every thing the Wisdom of the great Architect of Nature: But it is also the most likely Means, to make the Gift of kind Providence, this natural World, the more beneficial to us, by teaching us how, both to avoid what is Hurtful, and to pursue what is most Useful and Beneficial to us."

"In the Year 1740, I wrote to Dr. Martin Physician to Lord Cathcart, General of the Forces which lay imbarked at Spithead, for an Expedition in America, to propose (besides the usual sprinkling between Decks with Vinegar) the hanging up very many Cloths dipped in Vinegar, in proper Places between Decks, in order to make the Air more wholesome: And in case an infectious Distemper should be in any Ship, to cure the Infection with the Fumes of burning Brimstone."

"[I]t occurred to me the March following, that large Ventilators would be very serviceable, in making the Air in Ships more wholesome; this I was so fully satisfied of, that I immediately drew up an Account of it; several Copies of wbich were communicated, both by my self and others, to many Persons of Distinction, and Members of the Royal Society: Before whom I laid a large Account of it, which was read in their Presence the May following..."

"November the sixth following, viz. in the Year 1741 Martin Triewald, Captain of Mechanicks and Military Architect to the King of Sweden, and Fellow of the Royal Society at London, in a Letter to M.D. and Secretary of the Royal Society, says, that "this Spring he had invented a Machine, for the Use of his Majesty's Men of War, which went to block up Petersburgh, in order to draw out the bad Air from under their Decks, the least of which does exhaust 36172 cubick Feet of Air in an Hour,"..."

"He proposes also to prevent Sea-Sickness thereby, by having a Man thus shut up in a close Cabin in a compressed Air: This, I suppose, has led some to say, that this and my Proposal are the same. But bow wide is their Difference! My Ventilators are intended to promote a free Perspiration and Breathing, by conveying great Quantities of fresh Air into Ships, in exchange for very bad Air. On the contrary, Dr. Henshaw's Conetrivance would make a good Air, by confining it, very bad, and thereby retard Perspiration, and incommode the Breathing, and so cause, instead of preventing, Sickness... Besides, the Make of my Ventilators is very different from that of Organ-Bellows."

"It were a very extraordinary Circumstance that two Persons at so great a Distance from each other, without getting a Hint of it one from the other, should happen to hit on inventing a like very useful Engine."

"The following Character of the late Dr. Hales, may he relied upon in every particular, and it is to he regretted that we have not more particulars concerning his useful Life from the same hand. On Sunday the 4th instant [1761], died, at his parsonage-house at Tedington, universally lamented, in the 83rd year of his age, the Rev. Dr. Stephen Hales, F.R.S., member of the royal academy of sciences at Paris and clerk of the closet to her Royal Highness the Princess Dowager of Wales. If any man might ever be said to have devoted his whole life to the public, to all mankind, it was Dr. Hales. He possessed a native innocence and simplicity of manners, which the characters of other men, and the customs of the world, could never alter; and though he often met with many unworthy objects of his kind and charitable offices, yet they never once lessened his natural and unwearied disposition of doing good and relieving distress. His temper, as well as the powers of his understanding, were happily fitted for the improvement of natural philosophy, possessing, as he did, in an uncommon degree, that industry and patient thinking, which Sir Isaac Newton used modestly to declare, was his own only secret by which he was enabled so fortunately to trace the wonderful analysis of nature. Dr. Hales began his inquiries into natural knowledge very early in life, and he continued it uniformly as his darling amusement, being engaged in experiments until within a few weeks of his death. His industry had this farther excellence, that it was always pointed at the general good of his fellow creatures, agreeable to the almost unlimited benevolence of his heart; and being animated with the success of some of his more useful discoveries, his knowledge appeared to everybody near him to feed his mind with a nourishment which gave him, in the decline of his life, and even in its last stages that vigor and serenity of understanding, and clearness of ideas, which so few possess, even [in] the flower of manhood; and which he used often to say, he valued as the most perfect of human pleasures. ...There are two things in his character, which particularly distinguish him from almost every other man; the first was, that his mind was so habitually bent on acquiring knowledge, that, having what he thought an abundant income, he was solicitous to avoid any farther preferment in the church, lest his time and attention might thereby be diverted from his other favorite and useful occupations. The other feature of his character was no less singular: He could look even upon wicked men, and those who did him unkind offices without any emotion of particular indignation; not for want of discernment or sensibility; but he used to consider them only as those experiments which, upon trial, he found could never be applied to any useful purpose, and which he therefore calmly and dispationately laid aside."

"'Tis a good Symptom that we are got upon a right Scent, when it leads not only to the Thing first sought for; but also to many other useful Discoveries, as we see this does."

"The other great advantage of the seasons, both earthly and liturgical, is that they circle slowly round quite independently of one’s own moods and thus become a corrective and offer perspective. I may be feeling glum, but Easter reminds me of resurrection anyway, I may be swayed by some splurge of Christmas consumerism but Advent reminds me that all I really need is the savior who is coming and for whose advent I should prepare. So the seasons, like all the old liturgical patterns, like the practice of reading scripture, can set us free from the tyranny of our own mood swings. In that sense they are always a blessing."

"Cells specialise in ways determined by the concentration of signal that they receive ... The best example of signaling between cells is by the signal molecule activin, discovered in embryos by Makoto Asashima and J. C. Smith."

"For these early results in Xenopus to be reproduced in mammals took nearly 40 years (Campbell et al. 1996; Wilmut et al. 1997) in sheep. A very important feature of these first successful mammalian nuclear transfer in sheep was the use of unfertilised eggs, as was actually used in amphibia. Earlier work with mice (McGrath and Solter 1984) used fertilised eggs. Although fertilised eggs can be used (Egli et al. 2007), synchronisation between nucleus and egg is harder to achieve than with the use of unfertilised eggs. A very elegant and important experiment that confirmed the general principle that cell differentiation proceeds with the retention of a complete set of genes was carried out using nuclei with a rearranged genome from mature mouse B or T donor cells (Hochedlinger and Jaenisch 2002). In the course of time, somatic cell nuclear transfer to eggs has been successful in the eggs of mice and other mammals (Wakayama et al. 1998). In each species there seem to be some technical requirements which have to be identified and overcome."

"My own view of development is that one has to try to narrow things down to single entities, whether it's a cell or a nucleus or a molecule, and I'm often ridiculed because I always ask people what concentration their molecule is at, and they'll say that it doesn't matter. I'd say that concentration and time are the two critical things in development. You need to know the concentration, and you need to know how long it has to be there to make a difference – because for cells, a particular concentration of a molecule for a few seconds may not be the same as that concentration for 10 minutes. So I would take the view that what we really lack in developmental biology at the moment is any ability to determine the concentration of proteins, analogous to the measurement of nucleic acids using PCR."

"Gurdon's (1962) nuclear transplantation experiments showed that genes were neither lost nor permanently inactivated during development. Upon transfer of an intestinal cell nucleus into an enucleated egg, entire swimming tadpoles developed. However, the frequency of this event was low, unless nuclei were first injected into oocytes (DiBerardino et al., 1986), a step that might allow reprogramming by stripping the DNA of mitotically heritable regulatory influences. Thus, although these experiments provided strong evidence that differentiation was reversible, they did not determine whether genes were silenced by active or passive mechanisms in the course of development."

"Michail Fischberg was well aware of the value of genetics in developmental biology, and when I joined him, he had just started using Xenopus as a laboratory animal, on the grounds that it could be grown to sexual maturity within a year and that, as it is wholly aquatic, it is easy to keep in the laboratory. Xenopus can deliver eggs throughout the year, in contrast to the limited-season availability of eggs from Rana and European newts, the organisms of choice for European embryologists. The history of how a frog that naturally occurs only in Africa has come to be one of the half-dozen most used animals for research is bizarre (Gurdon & Hopwood 2000)."

"Newton's Dictionary of Birds, published in four parts by Adam & Charles Black, London, between 1893 and 1896, and as a single bulky volume in 1896 was his magnum opus (Dawson 2008), a monumental work that inspired awe and admiration from all reviewers. ... Newton's main achievements are threefold: (1) helping to initiate the British Ornithologists’ Union and its journal The Ibis, (2) promoting the conservation of birds and (3) his Dictionary of Birds."

"Certainly humans can be destructive and shortsighted; they can also be forward-thinking and altruistic. Time and time again, people have demonstrated that they care about what Rachel Carson called "the problem of sharing our earth with other creatures," and that they're willing to make sacrifices on those creatures' behalf. Alfred Newton described the slaughter that was occurring along the British coast; the result was the Act for the Preservation of Sea Birds..."

"Newton's conversatism is evident in everything connected with his life—his views upon most subjects, his personal habits, attire, etc., but curiously enough we find him among the first to adopt the ideas of Darwin and Wallace on evolution and one of their staunch supporters in the stormy discussions which rent the British Association in the early sixties."

"One species, L. excubitor, derives it trivial designation from the use made of it as a sentinel by falconers when catching wild Hawks. The mode employed is well described by Hoy (Mag. Nat. Hist. iv. p. 342), but it can only be briefly described here. The Hawk-catcher lies hidden in a hut, watching through a small hole the Butcher-bird which is tethered some yards off, and by its actions not only gives him notice of the approach of a Bird-of-Prey, but also indicates of what kind the stranger is. Thus the sentinel is but slightly troubled at a passing Kite, Eagle, or Buzzard; but beats itself on its perch with screams at the sight of a Harrier, while on the appearance of a Falcon or Sparrow-Hawk it drops with cries of distress into a retreat that has been been considerately prepared for it. On this the falconer, by pulling long strings, displays first one and then a second tethered Pigeon, and the instant the Hawk clutches this last, draws a bow-net over both, thus securing his prize."

"Here is a zoological anecdote. Mr. G. X. is very ugly and hairy. He went to call at a house a few days ago and found only a little girl in the drawing-room. He began to say something civil to her but she would not answer. At last he said, "You don't know who I am!" "Yes, I do," she replied, "I gave you a bun at the Zoological Gardens last Sunday—and, you naughty man, you had no clothes on!""

"To attempt the taking of an Ornithological Census of these islands was a favourite idea of Mr. John Wolley's; so much so, indeed, that I believe he used to regard its accomplishment as the chief requirement of British ornithology. ... Two of the expressions which have lately become very familiar to the ears of naturalists are the "Struggle for Life," and "Preservation of Favoured Races" therein. Each of these points, as it seems to me, would be greatly elucidated by the carrying-out of Mr. Wolley's idea.""