First Quote Added
April 10, 2026
Latest Quote Added
"Information in life... amounts to much more than just playing the margins of the , and gaining some... energy advantage. ...I'm calling this a demonic cut. It's much more than just Shannon s at the thermodynamic level. Biological information is... contextual, or functional, or semantic. It depends upon the overall system."
"[A]t what point does information, in the physics of matter, cease to just be a thermodynamic issue, and become much more of a control issue? ...[O]ne place ...is the . ...[H]ow did this come into existence?"
"We lack any sort of device that can... detect life. We don't have a life meter. ...We don't have a general purpose life meter that can detect life as we don't know it."
"[[Max DelbrĂźck|[M]ax DelbrĂźck]]... expressed it... (to encapsulate)... [A]t the level of atoms it's just known physics, but at the level of the living cell it's some sort of magic."
"The fundamental problem about trying to define life... If you go to a physics department... you'll be given a definition in terms of matter... force... energy... entropy... free energy, molecular binding affinities, and so on. If you go to a biology department... you'll be given a very different narrative in terms of... instructions, transcription, , translation, coding, signals..."
"[B]iologists... define life in terms of its informational qualities... physicists tend to define life in terms of the physical qualities."
"[W]e... need some new physics. ...The attempt to square the circle by starting out with known physics at the atomic level and somehow life emerging at some higher level... I... don't think we're going to be able to do it without new physics."
"[[Information theory|[I]nformation]] pervades biology. Your DNA is chock full of encrypted information, and the encryption is really important. But s don't act in isolation. They couple together to form networks, sometimes of great complexity, and information swirls around these networks. It can be stored.... processed... and it can have knock-on effects... beyond individual cells. Even bacteria can signal each other chemically... electrically and mechanically, and so, through physical forces, can exchange information and engage in cooperative behavior, like in s."
"Life was onto this... billions of years ago. Life uses many many nano-molecules... in effect, Maxwell demons. Our bodies are full of [them]... doing the business of life. ...not quite perfect ...but they're coming pretty close to the theoretical limit, in terms of energy expenditure."
"If ever you want an example of going from physics to biology, it's the origin of the ."
"The laws of nature are rigged not only in favor of complexity, or just in favor of life, but also in favor of mind. To put it dramatically, it implies that mind is written into the laws of nature in a fundamental way."
"In each and every one of us lies a message. It is inscribed in an ancient code, its beginnings lost in the mists of time. Decrypted, the message contains instructions on how to make a human being. Nobody wrote the message; nobody invented the code. They came into existence spontaneously. Their designer was Mother Nature herself, working only within the scope of her immutable laws and capitalizing on the vagaries of chance.The message isn't written in ink or type, but in atoms, strung together in an elaborately arranged sequence to form DNA, short for deoxyribonucleic acid. It is the most extraordinary molecule on Earth."
"To a physicist like me, life looks to be little short of magic: all those dumb molecules conspiring to achieve such clever things!"
"Human beings have always been struck by the complex harmony and intricate organization of the physical world. The march of the heavenly bodies across the sky, the rhythms of the seasons, the pattern of a snowflake, the myriads of living creatures so well adapted to their environment â all these things seem too well arranged to be a mindless accident."
"What is remarkable is that human beings are actually able to carry out this code-breaking operation, that the human mind has the necessary intellectual equipment for us to "unlock the secrets of nature"..."
"I cannot believe that our existence in this universe is a mere quirk of fate, an accident of history, an incidental blip in the great cosmic drama. Our involvement is too intimate."
"The thing that separates life from non-life is information."
"That the universe has organized its own self-awareness â is for me powerful evidence that there is 'something going on' behind it all. The impression of design is overwhelming. Science may explain all the processes whereby the universe evolves its own destiny, but that still leaves room for there to be a meaning behind existence."
"The brain is the medium of expression of the human mind. Similarly the entire physical universe would be the medium of expression of the mind of a natural God."
"Matter as such has been demoted from its central role, to be replaced by concepts such as organization, complexity and information."
"Science, it is usually believed, helps us to build a picture of objective reality â the world 'out there'. With the advent of the quantum theory, that very reality appears to have crumbled, to be replaced by something so revolutionary and bizarre that its consequences have not yet been properly faced."
"All this prompts the question of why, from the infinite rage of possible values that Nature could have selected for the fundamental constants, and from the infinite variety of initial conditions that could have characterized the primeval universe, the actual values and conditions conspire to produce the particular range of special features that we observe. For clearly the universe is a very special place: exceedingly uniform on a large scale, yet not so precisely uniform that galaxies could not form; extremely low entropy per proton, and hence cool enough for chemistry to happen; almost zero cosmic propulsion and an expansion rate tuned to that energy content to unbelievable accuracy; values for the strengths of its forces that permit nuclei to exist, yet do not burn up all the cosmic hydrogen, and many more apparent accidents of fortune."
"The scientific quest is a journey into the unknown."
"Seventy-five years ago Erwin SchrĂśdinger published... '... the key point... was whether life can be explained by physics. ...SchrĂśdinger ...said "We must be prepared to find a new kind of physical law prevailing...""
"s are the way in which... you are thinking and paying attention, because the signals that travel between neurons, down the s, are controlled by the flow of s across the membranes of the axons... [T]hey are, in effect, little demons that sense the incoming signal and open and close the gates; and the ions flow. ...[T]his is so incredibly energy efficient that ...your brain, which is like a megawatt supercomputer, operates with the energy equivalent of a small light bulb."
"[T]here is... not just [some] new physical law, but a new kind of physical law. ...[W]hat kind of physical law? ...[O]ne idea that Sarah Walker and I have flirted with is state-dependent laws of information. ...[T]ake chess as an analogy ...If you had a modified game of chess in which the rules ...could be updated according to the state of play ...this opens the way to new forms of complexity and new forms of configuration."
"It's now commonplace to have an informational term entering into the fundamental laws of physics as a source of free energy."
"We want to know the transition zone between this demonic cut... from just Shannon] bits of information... to this more complex form of global, or contextual, or functional information. ...[H]azarding some guesses ...it might be a transition that would be measured by the integrated information, or... pathway complexity that Lee Cronin toyed with, or the breakdown of unitarity, if you think that this is associated in some way with the quantum classical transition."
"In the emerging picture of mankind in the universe, the future (if it exists) will surely entail discoveries about space and time which will open up whole new perspectives in the relationship between mankind, mind, and the uni-verse.⌠But what is now? There is no such thing in physics;it is not even clear that ânowâ could ever be described, let alone explained, in terms of physics.⌠Notions such as âthe past,â âthe presentâ and âthe futureâ seem to be more linguistic than physical.⌠There is no universal now, but only a personal oneâa âhere and now.â This strongly suggests that we look to the mind, rather than to the physical world, as the origin of the division of time into past, present, and future.âŚThere is none of this in physics.⌠No physical experiment has ever been performed to detect the passage of time. As soon as the objective world of reality is considered, the passage of time disappears like a ghost into the night."
"I know of no theorem that tells you... the maximum amount of change that agency can achieve in the universe, and what interests me... is agency at the end of the universe. If you end up in , which has a temperature and a horizon entropy, can you do anything with... those thermal fluctuations? Can you mine them... to extract energy?"
"Nature cannot achieve the first-best outcomes to which those like Kant aspire because the latter are not incentive-compatible. That is to say, they are achievable only if the human beings who live in the society act in a manner that is incompatible with their nature."
"Despite his inability to build a system, Sidgwick had made Cambridge Benthamite in its social reasoning. Perhaps this development was always inevitable in a university which had aimed to turn out mathematical rather than classical curates. But it had important consequences. Only a philosophy based on a hedonistic calculus could provided exact reasoning about social policy. Alfred Marshall was a product of Sidgwick's Cambridge. On the other hand, Sidgwick left moral philosophy in a mess. Intuitionist ideas revived, with an admixture of Hegelianism, in the more dynamic form of Idealism. But its headquarters were at Oxford rather than Cambridge; its high priests the Oxford philosophers Bradley and T. H. Green. Cambridge had become too critical, too empirical, to accept its ethics in metaphysical form. The way was open for G. E. Moore to construct a Cambridge system detached from both Benthamism and metaphysics. Moore was as much a product of Sidgwick's failure as was Marshall."
"The last comprehensive attempt to restate the principles of a free society, already much qualified and in the restrained form expected of an academic textbook, is Henry Sidgwick, The Elements of Politics (London: Macmillan, 1891). Though in many respects an admirable work, it scarcely represents what must be regarded as the British liberal tradition and is strongly tainted with that rationalist utilitarianism which led to socialism."
"The method is Bentham's; but there is none of Bentham's strong critical antagonism to the institutions of his time, and the mode of thought is much more what we might expect from an end-of-the-nineteenth-century Blackstone, or from an English Hegel, showing the rationality of the existing order of things, with only a few modest proposals of reform. If this is Benthamism, it is Benthamism grown tame and sleek."
"[T]he inhuman severity of the paradox that âpleasure and pain are indifferent to the wise man,â never failed to have a repellent effect; and the imaginary rack on which an imaginary sage had to be maintained in perfect happiness, was at any rate a dangerous instrument of dialectical torment or the actual philosopher. Christianity extricated the moral consciousness from this dilemma between base subserviency and inhuman indifference to the feelings of the moral agent. It compromised the long conflict between Virtue and Pleasure, by transferring to another world the fullest realisation of both; thus enabling orthodox morality to assert itself, as reasonable and natural, without denying the concurrent reasonableness and naturalness of the individualâs desire for bliss without allow."
"[T]he history of thought [âŚ] reveal[s] discrepancy between the intuitions of one age and those of a subsequent generation. But where the conflicting beliefs are not contemporaneous, it is usually not clear that the earlier thinker would have maintained his conviction if confronted by the arguments of the later. The history of thought, however, I need hardly say, affords abundant instances of similar conflict among contemporaries; and as conversions are extremely rare in philosophical controversy, I suppose the conflict in most cases affects intuitionsâwhat is self-evident to one mind is not so to another. It is obvious that in any such conflict there must be error on one side or the other, or on both. The natural man will often decide unhesitatingly that the error is on the other side. But it is manifest that a philosophic mind cannot do this, unless it can prove independently that the conflicting intuitor has an inferior faculty of envisaging truth in general or this kind of truth; one who cannot do this must reasonably submit to a loss of confidence in any intuition of his own that thus is found to conflict with anotherâs."
"The denial of any distinction between foreseen and intended consequences, as far as responsibility is concerned, was not made by Sidgwick in developing any one 'method of ethics'; he made this important move on behalf of everybody and just on its own account; and I think it plausible to suggest that this move on the part of Sidgwick explains the difference between old-fashioned Utilitarianism and the consequentialism, as I name it, which marks him and every English academic moral philosopher since him."
"J. J. C. Smart, a prominent 20th-century utilitarian, said simply that [Sidgwick's] The Methods is âthe best book ever written on ethicsâ. Derek Parfit agreed with that judgement, acknowledging that some books, like Platoâs Republic and Aristotleâs Ethics, are greater achievements, but noting that because Sidgwick could build on the work of his predecessors, The Methods âcontains the largest number of true and important claimsâ."
"For philosophy and history alike have taught...to seek not what is "safe," but what is true."
"I may begin by laying down as a principle that âall pain of human or rational beings is to be avoidedâ; and then afterwards may be led to enunciate the wider rule that âall pain is to be avoidedâ; it being made evident to me that the difference of rationality between two species of sentient beings is no ground for establishing a fundamental ethical distinction between their respective pains."
"It is sometimes said that we live in an age that rejects authority. The statement, thus qualified, seems misleading; probably there never was a time when the number of beliefs held by each individual, undemonstrated and unverified by himself, was greater. But it is true that we only accept authority of a peculiar sort; the authority, namely, that is formed and maintained by the unconstrained agreement of individual thinkers, each of whom we believe to be seeking truth with single-mindedness and sincerity, and declaring what he has found with scrupulous veracity, and the greatest attainable exactness and precision."
"Is it total or average happiness that we seek to make a maximum?...we foresee as possible that an increase in [population] numbers will be accompanied by a decrease in average happiness...if we take Utilitarianism to prescribe, as the ultimate end of action, happiness on the whole...it would follow that, if the additional population enjoy on the whole positive happiness, we ought to weigh the amount of happiness gained by the extra number against the amount lost by the remainder. So that, strictly conceived, the point up to which, on Utilitarian principles, population ought to be encouraged to increase, is not that at which average happiness is the greatest possible...but that at which the product formed by multiplying the number of persons living into the amount of average happiness reaches its maximum."
"it seems scarcely extravagant to say that, amid all the profuse waste of the means of happiness which men commit, there is no imprudence more flagrant than that of Selfishness in the ordinary sense of the term,âthat excessive concentration of attention on the individualâs own happiness which renders it impossible for him to feel any strong interest in the pleasures and pains of others."
"Many religious persons think that the highest reason for doing anything is that it is Godâs Will: while to others âSelf-realisationâ or âSelf-developmentâ, and to others, again, âLife according to natureâ appear the really ultimate ends. And it is not hard to understand why conceptions such as these are regarded as supplying deeper and more completely satisfying answers to the fundamental question of Ethics, than those before named: since they do not merely represent I what ought to be, as such; they represent it in an apparently simple relation to what actually is. God, Nature, Self, are the fundamental facts of existence; the knowledge of what will accomplish Godâs Will, what is, âaccording to Natureâ, what will realise the true Self in each of us, would seem to solve the deepest problems of Metaphysics as well as of Ethics. But [âŚ] [t]he introduction of these notions into Ethics is liable to bring with it a fundamental confusion between âwhat isâ and âwhat ought to beâ, destructive of all clearness in ethical reasoning: and if this confusion is avoided, the strictly ethical import of such notions, when made explicit, appears always to lead us to one or other of the methods previously distinguished."
"Now, I agree with Mill in holding that the scientific study of the structures and functions of the different governments that have actually existed in human societies cannot well be pursued in complete separation from the scientific study of other important elements of the societies in question: whether the aim of the student is to ascertain the causes of the differences in such governments or to examine their effects. But I do not think that there is any fundamental difference, in this respect, between the study of political relations and the study of economic relations, or, again, of religion, of art, of science and philosophy, as factors of social life. In each of these eases the student concentrates his attention on one element of human history which can only be partially separated from other components of the whole complex fact of social development. Experience seems to show that this kind of concentration, and consequent partial separation of historical and sociological study into special branches, is unavoidable in the division of intellectual labour which the growth of our knowledge renders necessary in a continually increasing degree."
"It is in their purely physical aspect, as complex processes of corporeal change, that [physical processes] are means to the maintenance of life: but so long as we confine our attention to their corporeal aspect,âregarding them merely as complex movements of certain particles of organised matterâit seems impossible to attribute to these movements, considered in themselves, either goodness or badness. I cannot conceive it to be an ultimate end of rational action to secure that these complex movements should be of one kind rather than another, or that they should be continued for a longer rather than a shorter period. In short, if a certain quality of human Life is that which is ultimately desirable, it must belong to human Life regarded on its psychical side, or, briefly, Consciousness."
"How far we are to consider the interests of posterity when they seem to conflict with those of now-existing human beings? The answer to this, though, seems clear: the time at which a man exists canât affect the value of his happiness from a universal point of view; so the interests of posterity must concern a utilitarian as much as those of his contemporariesâexcept in that the effect of his actions on the lives and even the existence of posterity must be more uncertain."
"A universal refusal to propagate the human species would be the greatest of conceivable crimes from a Utilitarian point of view"
"Each person is morally obliged to regard the good of anyone else as much as his own good, except when he judges it to be less, when impartially viewed, or less certainly knowable or attainable by him."
"The good of any one individual is of no more importance, from the point of view...of the Universe, than the good of any other; unless, that is, there are special grounds for believing that more good is likely to be realized in the one case than in the other."