geneticists

"Living cells respond to DNA damage by a variety of mechanisms, including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases, called base excision repair, mismatch repair and nucleotide excision repair (NER). NER in human cells is a complex biochemical process during which a large multiprotein complex is assembled at several types of base damage. This multiprotein complex (NER machine) catalyses the excision of damaged bases as oligonucleotide fragments."

"Oppenheimer is a medical doctor who has lived in Southeast Asia for decades. Like most of us, he is vaguely influenced by Marxism, e.g. where he dismisses religion as a means to “control other people's labour”, with explicit reference to Karl Marx’s Das Kapital. His book is based on solid scientific research (genetic, anthropological, linguistic and archaeological), and is in that respect very different from the numerous Atlantis books which draw on “revelations” and “channeling”... Stephen Oppenheimer makes a detailed and strong case for the importance of the culture of sunken Sundaland for the later cultures in the wide surroundings. India too must have benefited of certain achievements and human cargo imported from there."

"We find the highest rates and greatest diversity of the M17 line in Pakistan, India, and eastern Iran, and low rates in the Caucasus. M17 is not only more diverse in South Asia than in Central Asia, but diversity characterizes its presence in isolated tribal groups in the South, thus undermining any theory of M17 as a marker of a “male Aryan invasion” of India. One average estimate for the origin of this line in India is as much as 51,000 years. All this suggests that M17 could have found his way initially from India or Pakistan, through Kashmir, then via Central Asia and Russia, before finally coming into Europe. (Oppenheimer, 2003: 152)"

"Barley cultivation was developed in the Indus Valley."

"Another geneticist, S. Oppenheimer, offers independent confirmation (2003) that there was no Aryan entry, either male or female; he focuses on the M17, or so-called “Caucasoid” (=Aryan!), genetic marker: “South Asia is logically the ultimate origin of M17 and his ancestors; and sure enough we find highest rates and greatest diversity of the M17 line in Pakistan, India and eastern Iran, and low rates in the Caucasus. M17 is not only more diverse in South Asia than in Central Asia but diversity characterizes its presence in isolated tribal groups in the south, thus undermining any theory of M17 as a marker of a ‘male Aryan invasion’ of India” ."

"Oppenheimer, a leading advocate of this scenario, summarizes it in these words: “For me and for Toomas Kivisild, South Asia is logically the ultimate origin of M17 and his ancestors; and sure enough we find the highest rates and greatest diversity of the M17 line in Pakistan, India, and eastern Iran, and low rates in the Caucasus. M17 is not only more diverse in South Asia than in Central Asia, but diversity characterizes its presence in isolated tribal groups in the south, thus undermining any theory of M17 as a marker of a ‘male Aryan invasion’ of India. One average estimate for the origin of this line in India is as much as 51,000 years. All this suggests that M17 could have found his way initially from India or Pakistan, through Kashmir, then via Central Asia and Russia, before finally coming into Europe.”"

"Yet the class structure which cripples Britain more than any other European state, is as nothing compared with the stratified hierarchies in Austronesian traditional societies from Madagascar through Bali to Samoa. (...) This consciousness of rank is thus clearly not something that was only picked up by Austronesian societies from later Indian influence.” (p.484)"

"First, that the Europeans’ genetic homeland was originally in South Asia in the Pakistan/Gulf region over 50,000 years ago; and second, that the Europeans’ ancestors followed at least two widely separated routes to arrive, ultimately, in the same cold but rich garden. The earliest of these routes was the Fertile Crescent. The second early route from South Asia to Europe may have been up the Indus into Kashmir and on to Central Asia, where perhaps more than 40,000 years ago hunters first started bringing down game as large as mammoths."

"We have a brain that just is desperate for . I mean, it's such a fussy organ. That's the only thing it really takes in for energy. Well, meat is not a very good source of glucose. To have a big brain like this, you need to eat something different, and the most efficient way to get glucose is to eat carbohydrates."

"Where people worry is when you get to the brain, the germ cells and the sentinel features that help people recognize what is a person, as opposed to a rat or a rabbit. Things like skin texture, facial shape, speech, replacing brain cells with human cells, allowing the development of human germ cells in animals. And particularly where there is any possibility of fertilisation within an animal."

"Changing animals by putting human genes or cells into their structure is one way of making them more resemble the bit of the human condition you're interested in studying."

"All great minds have their unique style and Bill Hamilton was no different. While Huey Newton would blast you against the far wall with the force of his argument, you had to lean in to hear what Bill was saying, so soft was he spoken. It was almost as if he clutched his thoughts close to the chest, but the effort on your part was well worth it. His every thought on every topic was worth your close attention."

"The incursions of barbaric pastoralists seem to do civilizations less harm in the long run than one might expect. Indeed, two dark ages and renaissances in Europe suggest a recurring pattern in which a renaissance follows an incursion by about 800 years. It may even be suggested that certain genes or traditions of the pastoralists revitalize the conquered people with an ingredient of progress which tends to die out in a large panmictic population for the reasons already discussed. I have in mind altruism itself, or the part of the altruism which is perhaps better described as self-sacrificial daring. By the time of the Renaissance it may be that the mixing of genes and cultures (or of cultures alone if these are the only vehicles, which I doubt) has continued long enough to bring the old mercantile thoughtfulness and the infused daring into conjunction in a few individuals who then find courage for all kinds of inventive innovation against the resistance of established thought and practice. Often, however, the cost in fitness of such altruism and sublimated pugnacity to the individuals concerned is by no means metaphorical, and the benefits to fitness, such as they are, go to a mass of individuals whose genetic correlation with the innovator must be slight indeed. Thus civilization probably slowly reduces its altruism of all kinds, including the kinds needed for cultural creativity"

"Conceptual simplicity, recursiveness, and formal separation of levels of selection are attractive features of these equations. But, of course, being able to point to a relevant and generally non-zero part of selective change is far from showing that group selection can override individual selection when the two are in conflict. Moreover, even the possibility of devising model circumstances in which a positive group-selection term (first term) outweighs a negative individual selection one (second term, assuming no further levels), gives no guarantee that ‘altruism’ can evolve by group selection: we have to consider whether the population can get into the specified state, and, if it can, whether its present trend will continue."

"If humans turn out to be near the Kondrashov limit —that is, if on average every gamete has one bad mutation created during the lifetime of its producer— it is obviously not going to be nearly enough to test a baby for the subset of the few hundreds or so of well-characterized genetic defects"

"Whether or not a researcher of a certain notoriety deserves that the ‘support system’ [to] keep him going, there is a far more general problem: What props up biological research, at least in the vaunted US of A, involves a situation so deeply imbued with entitlement mentality that it has sunk into institutional corruption. A principal symptom of this state of affairs involves the following: People are hired after they have undergone long stints of training; and a potential hiree must present a large body of documented accomplishments. In my day you could get a faculty job with zero post-doc papers, as in the case of yours truly; but now the CV of a successful applicant looks like that of a newly minted full Professor from olden times. Notwithstanding these demands, and the associated high quality of a fledgling faculty-level type, the job starts with some “set-up” money for equipping the lab; but next to no means are provided to initiate that ‘research program’ and to sustain it during the years to come."

"US institutions (possibly also those in other countries) behave as though they… are entitled to research funding, which will magically materialize from elsewhere: “Get a grant, serf! If you can’t do it quickly, or have trouble for some years — or if your funding doesn’t get renewed, despite continuing productivity — forget it!” But what if there are so many applicants (as there are nowadays) that even a meritorious proposal gets the supplicant nowhere or causes a research group to grind prematurely to a halt? What if the situation is worsened when the government at hand is anti-science and otherwise squanders its resources on international adventurism?"

"Having said all this, I acknowledge that “I got mine” from the government over the course of many years. Thus, as I say so long,” one component of my last-gasp disquiet stems from pompously worrying about biologists who are starting out or are in mid-career."

"In 1982 Barry visited Taiwan, where the director of the blood bank at a major hospital in Taipei showed him large refrigerators full of blood from people infected with hepatitis B. What should they do with all these contaminated bottles of blood, the director asked? Barry’s answer: they should make hepatitis B vaccine. The Taiwanese hospital adopted his recommendation, which led by 1984 to Taiwan establishing the world’s first program of universal hepatitis B vaccination."

"Primary cancer of the liver (hepatocellular carcinoma, HCC) is one of the most common cancers worldwide; HBV is the major cause of HCC. A vaccine that protects against HBV infection was invented in 1969 and is now one of the most commonly used vaccines. National vaccination programs have dramatically reduced the prevalence of HBV infection and carriers, with a concomitant decrease in the incidence of HCC in the vaccine-impacted populations. HBV vaccine is the first widely used cancer prevention vaccine; a second that protects against papilloma virus and cancer of the cervix has recently been introduced."

"Viral hepatitis is an inflammation of the liver caused by at least six different, mostly unrelated, viruses [hepatitis viruses A, B, C, D, E, and G (HAV, HBV, HCV, HDV, HEV, and HGV, respectively)]. It can occur in an acute form from which most patients experience a complete recovery. Acute viral hepatitis is characterized by an insidious onset, often with fever and severe malaise and loss of appetite for food, alcohol, and tobacco. Flu-like symptoms may occur early in the illness. The characteristic finding that occurs in many cases is the development of jaundice, a dramatic yellow discoloration of the skin and other surfaces. Symptoms may last for days or weeks. The acute disease usually results in complete recovery with lifelong immunity. Occasionally, acute hepatitis may advance to the fulminant phase; the patient does not recover, but develops liver failure and death may be rapid. Fortunately, this is rare. Hepatitis due to HAV and HEV is nearly always acute. Acute disease also may occur with HBV and probably HGV. HCV is usually chronic."

"In his early years as a physician, Baruch Blumberg developed a keen interest in the genetic polymorphisms and environmental factors that influence disease development. In particular, he was interested in the lipoprotein subtypes that predispose certain individuals to heart disease. As a scientific researcher, Blumberg, while studying these protein fractions, encountered an unusual protein in the serum of Australian aborigine patients with serum hepatitis."

"As a consequence of disease and environmental forces, as well as other factors, a large number of polymorphisms may exist in a population. Some may be related to present selective forces, and others to forces which operated in the past, but which are no longer significant. Present gene frequencies may also result from gene mixture between populations."

"An experiment conducted in the mid-nineteen forties prepared me to expect unusual responses of a genome to challenges for which the genome is unprepared to meet in an orderly, programmed manner. In most known instances of this kind, the types of response were not predictable in advance of initial observations of them. It was necessary to subject the genome repeatedly to the same challenge in order to observe and appreciate the nature of the changes it induces. Familiar examples of this are the production of mutation by X-rays and by some mutagenic agents. In contrast to such “shocks” for which the genome is unprepared, are those a genome must face repeatedly, and for which it is prepared to respond in a programmed manner. Examples are the “heat shock” responses in eukaryotic organisms, and the “SOS” responses in bacteria. Each of these initiates a highly programmed sequence of events within the cell that serves to cushion the effects of the shock. Some sensing mechanism must be present in these instances to alert the cell to imminent danger, and to set in motion the orderly sequence of events that will mitigate this danger. The responses of genomes to unanticipated challenges are not so precisely programmed. Nevertheless, these are sensed, and the genome responds in a descernible but initially unforeseen manner."

"When, through radiation or other causes, chromosomes are broken within a single nucleus, 2-by-2 fusions may occur between the broken ends. These fusions may lead to rearrangements of parts of the chromatin complement, giving rise to various chromosomal aberrations which are detected as reciprocal translocations, inversions, deficiencies, etc. Since, in the well-investigated cases, the breakages occurred within a single nucleus, the conditions that lead to fusions of broken ends could not easily be ascertained."

"In 1950, Barbara McClintock published a Classic PNAS article, “The origin and behavior of mutable loci in maize,” which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring."

"In the year of her election to the National Academy, she began the series of experiments that led her to transposition—work that many now see as the most important of her career. At the time, only she thought so. To most, her conclusions seemed too radical."

"If chromosomes are broken by various means, the broken ends appear to be adhesive and tend to fuse with one another 2-by-2. This has been abundantly illustrated in the studies of chromosomal aberrations induced by X-ray treatment. It also occurs after mechanical rupture of ring-shaped chromosomes during somatic mitoses in maize and is assumed to occur during the normal process of crossing-over."

"When Barbara McClintock was awarded a Nobel Prize for her work on gene transposition in corn plants, the most striking thing about her was that she made her discoveries by listening to what the corn spoke to her, by respecting the life of the corn and "letting it McClintock says she learned "the stories" of the plants. She "heard them. She watched the daily green journeys of growth from carth toward sky and sun. She knew her plants in the way a healer or mystic would have known them, from the inside, the inner voices of corn and woman speaking to one another. As an Indian woman, I come from a long history of people who have listened to the language of this continent, people who have known that corn grows with the songs and prayers of the people, that it has a story to tell, that the world is alive...This intuitive and common language is what I seek for my writing, work in touch with the mystery and force of life, work that speaks a few of the many voices around us, and it is important to me that McClintock listened to the voices of corn. It is important to the continuance of life that she told the truth of her method and that it reminded us all of where our strength, our knowing, and our sustenance come from. It is also poetry, this science, and I note how often scientific theories lead to the world of poetry and vision, theories telling us how atoms that were stars have been transformed into our living, breathing bodies. And in these theories, or maybe they should be called stories, we begin to understand how we are each many people, including the stars we once were, and how we are in essence the earth and the universe, how what we do travels clear around the earth and returns. In a single moment of our living, there is our ancestral and personal history, our future, even our deaths planted in us and already growing toward their fulfillment. The corn plants are there, and like all the rest we are forever merging our borders with theirs in the world collective."

"Key aspects of the bacteriophage work illustrate central features of Seymour's ability to design scientific investigations; these features played out again and again in his scientific career, to great success. One of these is the “simple assay.” Seymour was an enthusiast of developing and using simple assays to approach any biological question of interest. Why use a complicated, time-consuming assay if a simple one would address the question equally well? Using a simpler assay would give more time and opportunity to delve in greater depth into the specific scientific question, as well as allow more time and opportunity to address additional questions of great interest."

"The problems that Benzer and his students are solving are problems that scientists and philosophers from the beginning of recorded history have been unable to solve and also unable to ignore."

"The phenomenon of genetic recombination provides a powerful tool for separating mutations and discerning their positions along a chromosome. When it comes to very closely neighboring mutations, a difficulty arises, since the closer two mutations lie to one another, the smaller the probability that recombination between them will occur. Therefore, failure to observe recombinant types among a finite number of progeny ordinarily does not justify the conclusion that the two mutations are inseparable but can only place an upper limit on the linkage distance between them. A high degree of resolution requires the examination of very may progeny. This can best be achieved if there is available a selective feature for the detection of small proportions of recombination."

"Complex as it is, much of the vast network of cellular functions has been successfully dissected, on a microscopic scale, by the use of mutants in which one element is altered at a time. A similar approach may be fruitful in tackling the complex structures and events underlying behavior, using behavioral mutations to indicate modifications of the nervous system. Drosophila offers the same advantages to such a study as it did to classical genetics, namely, large numbers and short generation time, to which now may be added an enormous store of accumulated knowledge concerning the organism. Containing about 105 neurons, the fly's nervous system is roughly halfway, on a logarithmic scale, between a single neuron and the human brain, and the fly is possessed of a rich repertoire of behavior."

"DNA isn’t all that matters but it matters more than everything else put together."

"Understanding how DNA makes us who we are will teach us to be more tolerant of each other."

"We now know that DNA differences are the major systematic source of psychological differences between us. Environmental effects are important but what we have learned in recent years is that they are mostly random – unsystematic and unstable – which means that we cannot do much about them."

"We can not predict who will develop the cancer. Cancer is a just disease – it affects everyone, regardless of whether we are poor or rich, where we live, how we live."

"The more times your cells divide, the greater the chance of mutations that lead to cancer. That is why the average oncological patient is a mature person or even a senior."

"I had very happy high school years; I was not a very diligent student, but I had good achievements – I was a winner of biology and chemistry national competition, which gave me a lot of points when I decided to take the entrance examination for medicine, not being completely convinced of the medical profession, since there was never a doctor in my family."

"At a time when cancer was a rare disease, people lived shorter for other reasons. When there were no antibiotics, they often died for ordinary infections. I therefore think that the "cancer epidemic" does not result from changes in genetic predisposition or carcinogenic factors, but from the fact that in recent decades these imperfections of human nature have been revealed that were previously masked by other diseases."

"If you want to be a good doctor for patients, you need to devote some time to it, and if you want to have achievements in scientific research, you need to spend a lot of time in the laboratory. It is difficult to reconcile."

"In lectures, it is important that you lecture simply. We are interested in the smartest students, and we really should take care of those who have most difficulties to understand certain concepts. I try to balance it."

"Andrzej Szczeklik was a fascinating personality in many respects. The scope of his general knowledge was absolutely rare. He saw what others did not notice. It's enough to say he was a better doctor than a good doctor. He could look and listen to what the patient says. Looking, he already knew what was wrong, after little things, after grimaces, after the way of breathing, after the way someone sits down or gets up..."

"In science, wherever politics got involved, the results were deplorable."

"Faith is a large epistemic tool i.e. method of acquiring new knowledge for which reason is blind."

"Faith is accepted by free will, not by reason."

"“Whites” are not derived from a population that existed from time immemorial, as some people believe. Instead, “whites” represent a mixture of four ancient populations that lived 10,000 years ago and were each as different from one another as Europeans and East Asians are today."

"Ideologies that seek a return to a mythical purity are flying in the face of hard science."

"We warn that models in population genetics should be treated with caution. Although they provide an important framework for testing historical hypotheses, they are oversimplifications. For example, the true ancestral populations of India were probably not homogeneous as we assume in our model, but instead were probably formed by clusters of related groups that mixed at different times. (Reich et al. 2009: 492)"

"The mixture of highly differentiated populations is a recurrent process in our history."