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April 10, 2026
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"I think the ratio, R, of the time to sense the dose taken to the time required to take an excessive dose is an important quantity. R is very large for LSD (which I've never taken) and reasonably short for cannabis. Small values of R should be one measure of the safety of psychedelic drugs. When cannabis is legalized, I hope to see this ratio as one of the parameters printed on the pack. I hope that time isn't too distant; the illegality of cannabis is outrageous, an impediment to full utilization of a drug which helps produce the serenity and insight, sensitivity and fellowship so desperately needed in this increasingly mad and dangerous world."
"My high is always reflective, peaceable, intellectually exciting, and sociable, unlike most alcohol highs, and there is never a hangover. Through the years I find that slightly smaller amounts of cannabis suffice to produce the same degree of high, and in one movie theater recently I found I could get high just by inhaling the cannabis smoke which permeated the theater. There is a very nice self-titering aspect to cannabis. Each puff is a very small dose; the time lag between inhaling a puff and sensing its effect is small; and there is no desire for more after the high is there."
"I can remember the night that I suddenly realized what it was like to be crazy, or nights when my feelings and perceptions were of a religious nature. I had a very accurate sense that these feelings and perceptions, written down casually, would not stand the usual critical scrutiny that is my stock in trade as a scientist. If I find in the morning a message from myself the night before informing me that there is a world around us which we barely sense, or that we can become one with the universe, or even that certain politicians are desperately frightened men, I may tend to disbelieve; but when I'm high I know about this disbelief. And so I have a tape in which I exhort myself to take such remarks seriously. I say "Listen closely, you sonofabitch of the morning! This stuff is real!" I try to show that my mind is working clearly; I recall the name of a high school acquaintance I have not thought of in thirty years; I describe the color, typography, and format of a book in another room and these memories do pass critical scrutiny in the morning. I am convinced that there are genuine and valid levels of perception available with cannabis (and probably with other drugs) which are, through the defects of our society and our educational system, unavailable to us without such drugs. Such a remark applies not only to self-awareness and to intellectual pursuits, but also to perceptions of real people, a vastly enhanced sensitivity to facial expression, intonations, and choice of words which sometimes yields a rapport so close it's as if two people are reading each other's minds."
"Incidentally, I find that reasonably good insights can be remembered the next day, but only if some effort has been made to set them down another way. If I write the insight down or tell it to someone, then I can remember it with no assistance the following morning; but if I merely say to myself that I must make an effort to remember, I never do. I find that most of the insights I achieve when high are into social issues, an area of creative scholarship very different from the one I am generally known for."
"When I'm high I can penetrate into the past, recall childhood memories, friends, relatives, playthings, streets, smells, sounds, and tastes from a vanished era. I can reconstruct the actual occurrences in childhood events only half understood at the time. Many but not all my cannabis trips have somewhere in them a symbolism significant to me which I won't attempt to describe here, a kind of mandala embossed on the high. Free-associating to this mandala, both visually and as plays on words, has produced a very rich array of insights. There is a myth about such highs: the user has an illusion of great insight, but it does not survive scrutiny in the morning. I am convinced that this is an error, and that the devastating insights achieved when high are real insights; the main problem is putting these insights in a form acceptable to the quite different self that we are when we're down the next day."
"I do not consider myself a religious person in the usual sense, but there is a religious aspect to some highs. The heightened sensitivity in all areas gives me a feeling of communion with my surroundings, both animate and inanimate. Sometimes a kind of existential perception of the absurd comes over me and I see with awful certainty the hypocrisies and posturing of myself and my fellow men. And at other times, there is a different sense of the absurd, a playful and whimsical awareness. Both of these senses of the absurd can be communicated, and some of the most rewarding highs I've had have been in sharing talk and perceptions and humor. Cannabis brings us an awareness that we spend a lifetime being trained to overlook and forget and put out of our minds. A sense of what the world is really like can be maddening; cannabis has brought me some feelings for what it is like to be crazy, and how we use that word "crazy" to avoid thinking about things that are too painful for us. In the Soviet Union political dissidents are routinely placed in insane asylums. The same kind of thing, a little more subtle perhaps, occurs here: "did you hear what Lenny Bruce said yesterday? He must be crazy.""
"Cannabis also enhances the enjoyment of sex — on the one hand it gives an exquisite sensitivity, but on the other hand it postpones orgasm: in part by distracting me with the profusion of image passing before my eyes. The actual duration of orgasm seems to lengthen greatly, but this may be the usual experience of time expansion which comes with cannabis smoking."
"The cannabis experience has greatly improved my appreciation for art, a subject which I had never much appreciated before. The understanding of the intent of the artist which I can achieve when high sometimes carries over to when I'm down. This is one of many human frontiers which cannabis has helped me traverse. There also have been some art-related insights — I don't know whether they are true or false, but they were fun to formulate."
"There's a part of me making, creating the perceptions which in everyday life would be bizarre; there's another part of me which is a kind of observer. About half of the pleasure comes from the observer-part appreciating the work of the creator-part. I smile, or sometimes even laugh out loud at the pictures on the insides of my eyelids. In this sense, I suppose cannabis is psychotomimetic, but I find none of the panic or terror that accompanies some psychoses. Possibly this is because I know it's my own trip, and that I can come down rapidly any time I want to."
"I had become friendly with a group of people who occasionally smoked cannabis, irregularly, but with evident pleasure. Initially I was unwilling to partake, but the apparent euphoria that cannabis produced and the fact that there was no physiological addiction to the plant eventually persuaded me to try. My initial experiences were entirely disappointing; there was no effect at all, and I began to entertain a variety of hypotheses about cannabis being a placebo which worked by expectation and hyperventilation rather than by chemistry. After about five or six unsuccessful attempts, however, it happened."
"Now, there has been the view that ... if there is nothing special about us in space then maybe there is something special about us in time. ... To me, the principal trouble with this idea is that 99.998% of the lifetime of the universe, from its beginning to now, was over before humans appeared on the scene."
"I think people in power have a vested interest to oppose critical thinking."
"All of the books in the world contain no more information than is broadcast as video in a single large American city in a single year. Not all bits have equal value."
"Those who raise questions about the God hypothesis and the soul hypothesis are by no means all atheists. An atheist is someone who is certain that God does not exist, someone who has compelling evidence against the existence of God. I know of no such compelling evidence. Because God can be relegated to remote times and places and to ultimate causes, we would have to know a great deal more about the universe than we do to be sure that no such God exists. To be certain of the existence of God and to be certain of the nonexistence of God seem to me to be the confident extremes in a subject so riddled with doubt and uncertainty as to inspire very little confidence indeed."
"Who is more humble? The scientist who looks at the universe with an open mind and accepts whatever it has to teach us, or somebody who says everything in this book must be considered the literal truth and never mind the fallibility of all the human beings involved?"
"That kind of skeptical, questioning, "don't accept what authority tells you" attitude of science — is also nearly identical to the attitude of mind necessary for a functioning democracy. Science and democracy have very consonant values and approaches, and I don't think you can have one without the other."
"I would love to believe that when I die I will live again, that some thinking, feeling, remembering part of me will continue. But much as I want to believe that, and despite the ancient and worldwide cultural traditions that assert an afterlife, I know of nothing to suggest that it is more than wishful thinking. The world is so exquisite with so much love and moral depth, that there is no reason to deceive ourselves with pretty stories for which there's little good evidence. Far better it seems to me, in our vulnerability, is to look death in the eye and to be grateful every day for the brief but magnificent opportunity that life provides."
"Something dreadful happens to students between first and twelfth grades, and it's not just puberty."
"Every kid starts out as a natural-born scientist, and then we beat it out of them. A few trickle through the system with their wonder and enthusiasm for science intact."
"If you take a look at science in its everyday function, of course you find that scientists run the gamut of human emotions and personalities and character and so on. But there's one thing that is really striking to the outsider, and that is the gauntlet of criticism that is considered acceptable or even desirable. The poor graduate student at his or her Ph.D. oral exam is subjected to a withering crossfire of questions that sometimes seem hostile or contemptuous; this from the professors who have the candidate's future in their grasp. The students naturally are nervous; who wouldn't be? True, they've prepared for it for years. But they understand that at that critical moment they really have to be able to answer questions. So in preparing to defend their theses, they must anticipate questions; they have to think, “Where in my thesis is there a weakness that someone else might find — because I sure better find it before they do, because if they find it and I'm not prepared, I'm in deep trouble.""
"The truth may be puzzling. It may take some work to grapple with. It may be counterintuitive. It may contradict deeply held prejudices. It may not be consonant with what we desperately want to be true. But our preferences do not determine what's true. We have a method, and that method helps us to reach not absolute truth, only asymptotic approaches to the truth — never there, just closer and closer, always finding vast new oceans of undiscovered possibilities. Cleverly designed experiments are the key."
"In fact, the thickness of the Earth's atmosphere, compared with the size of the Earth, is in about the same ratio as the thickness of a coat of shellac on a schoolroom globe is to the diameter of the globe. That's the air that nurtures us and almost all other life on Earth, that protects us from deadly ultraviolet light from the sun, that through the greenhouse effect brings the surface temperature above the freezing point. (Without the greenhouse effect, the entire Earth would plunge below the freezing point of water and we'd all be dead.) Now that atmosphere, so thin and fragile, is under assault by our technology. We are pumping all kinds of stuff into it. You know about the concern that chlorofluorocarbons are depleting the ozone layer; and that carbon dioxide and methane and other greenhouse gases are producing global warming, a steady trend amidst fluctuations produced by volcanic eruptions and other sources. Who knows what other challenges we are posing to this vulnerable layer of air that we haven't been wise enough to foresee?"
"Humans — who enslave, castrate, experiment on, and fillet other animals — have had an understandable penchant for pretending animals do not feel pain. A sharp distinction between humans and 'animals' is essential if we are to bend them to our will, make them work for us, wear them, eat them — without any disquieting tinges of guilt or regret. It is unseemly of us, who often behave so unfeelingly toward other animals, to contend that only humans can suffer. The behavior of other animals renders such pretensions specious. They are just too much like us."
"The idea that God is an oversized white male with a flowing beard who sits in the sky and tallies the fall of every sparrow is ludicrous. But if by God one means the set of physical laws that govern the universe, then clearly there is such a God. This God is emotionally unsatisfying... it does not make much sense to pray to the law of gravity."
"We live in a society absolutely dependent on science and technology and yet have cleverly arranged things so that almost no one understands science and technology. That's a clear prescription for disaster."
"In science it often happens that scientists say, "You know that's a really good argument; my position is mistaken," and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion."
"It seems to me what is called for is an exquisite balance between two conflicting needs: the most skeptical scrutiny of all hypotheses that are served up to us and at the same time a great openness to new ideas ... If you are only skeptical, then no new ideas make it through to you ... On the other hand, if you are open to the point of gullibility and have not an ounce of skeptical sense in you, then you cannot distinguish the useful ideas from the worthless ones."
"Imagine, a room, awash in gasoline. And there are two implacable enemies in that room. One of them has 9,000 matches. The other has 7,000 matches. Each of them is concerned about who's ahead, who's stronger. Well, that's the kind of situation we are actually in. The amount of weapons that are available to the United States and the Soviet Union are so bloated, so grossly in excess of what's needed to dissuade the other that if it weren't so tragic, it would be laughable."
"It is easy to create an interstellar radio message which can be recognized as emanating unambiguously from intelligent beings. A modulated signal (‘beep,’ ‘beep-beep,’ . . . ) comprising the numbers 1, 2, 3, 5, 7, 11, 13, 17, 19, 23, 29, 31, for example, consists exclusively of the first 12 prime numbers—that is, numbers that can be divided only by 1, or by themselves. A signal of this kind, based on a simple mathematical concept, could only have a biological origin. . . . But by far the most promising method is to send pictures."
"There is a place with four suns in the sky — red, white, blue, and yellow; two of them are so close together that they touch, and star-stuff flows between them. I know of a world with a million moons. I know of a sun the size of the Earth — and made of diamond. There are atomic nuclei a few miles across which rotate thirty times a second. There are tiny grains between the stars, with the size and atomic composition of bacteria. There are stars leaving the Milky Way, and immense gas clouds falling into it. There are turbulent plasmas writhing with X- and gamma-rays and mighty stellar explosions. There are, perhaps, places which are outside our universe. The universe is vast and awesome, and for the first time we are becoming a part of it."
"I sit surrounded by cartons of mail from people all over the planet who mourn Carl's loss. Many of them credit him with their awakenings. Some of them say that Carl's example has inspired them to work for science and reason against the forces of superstition and fundamentalism. These thoughts comfort me and lift me up out of my heartache. They allow me to feel, without resorting to the supernatural, that Carl lives."
"Contrary to the fantasies of the fundamentalists, there was no deathbed conversion, no last minute refuge taken in a comforting vision of heaven or an afterlife. For Carl, what mattered most was what was true, not merely what would make us feel better. Even at this moment when anyone would be forgiven for turning away from the reality of our situation, Carl was unflinching. As we looked deeply into each other's eyes, it was with a shared conviction that our wondrous life together was ending forever."
"The world is so exquisite, with so much love and moral depth, that there is no reason to deceive ourselves with pretty stories for which there's little good evidence. Far better, it seems to me, in our vulnerability, is to look Death in the eye and to be grateful every day for the brief but magnificent opportunity that life provides."
"I would love to believe that when I die I will live again, that some thinking, feeling, remembering part of me will continue. But as much as I want to believe that, and despite the ancient and worldwide cultural traditions that assert an afterlife, I know of nothing to suggest that it is more than wishful thinking."
"Perhaps the most wrenching by-product of the scientific revolution has been to render untenable many of our most cherished and most comforting beliefs. The tidy anthropocentric proscenium of our ancestors has been replaced by a cold, immense, indifferent universe in which humans are relegated to obscurity. But I see the emergence in our consciousness of a Universe of a magnificence, and an intricate, elegant order far beyond anything our ancestors imagined. And if much about the Universe can be understood in terms of a few simple laws of Nature, those wishing to believe in God can certainly describe those beautiful eyes to a Reason underpinning all of Nature. My own view is that it is far better to understand the Universe as it really is than to pretend to a Universe as we might wish it to be."
"The most significant aspect of the DNA story is that the fundamental processes of life now seem fully understandable in terms of physics and chemistry. No life force, no spirit, no soul seems to be involved. Likewise in neurophysiology: Tentatively, the mind seems to be the expression of the hundred trillion neural connections in the brain, plus a few simple chemicals."
"We—we Americans, we Russians—have spent 43 years and vast national treasure in making ourselves exquisitely vulnerable to instant annihilation. We have done it in the name of patriotism and “national security,” so no one is supposed to question it."
"In both countries, what passes for public debate is still, on closer examination, mainly repetition of national slogans, appeal to popular prejudice, innuendo, self-justification, misdirection, incantation of homilies when evidence is asked for, and a thorough contempt for the intelligence of the citizenry."
"Widespread intellectual and moral docility may be convenient for leaders in the short term, but it is suicidal for nations in the long term. One of the criteria for national leadership should therefore be a talent for understanding, encouraging, and making constructive use of vigorous criticism."
"A central lesson of science is that to understand complex issues (or even simple ones), we must try to free our minds of dogma and to guarantee the freedom to publish, to contradict, and to experiment. Arguments from authority are unacceptable. We are all fallible, even leaders. But however clear it is that criticism is necessary for progress, governments tend to resist."
"The methods and ethos of science and religion are profoundly different. Religion frequently asks us to believe without question, even (or especially) in the absence of hard evidence. Indeed, this is the central meaning of faith. Science asks us to take nothing on faith, to be wary of our penchant for self-deception, to reject anecdotal evidence. Science considers deep skepticism a prime virtue. Religion often sees it as a barrier to enlightenment. So, for centuries, there has been a conflict between the two fields—the discoveries of science challenging religious dogmas, and religion attempting to ignore or suppress the disquieting findings."
"Why is “energy independence” mentioned so often as a justification for environmentally risky nuclear power plants or offshore drilling—but so rarely to justify insulation, efficient cars, or wind and solar energy?"
"If we are to prevent this climactic danger from working its worst, we will simply all have to work together, and for a long time. The principle obstacle is, of course, inertia, resistance to change—huge, worldwide, interlocking industrial, economic, and political establishments all beholden to fossil fuels, when fossil fuels are the problem. In the United States, as the evidence for the seriousness of global warming mounts, the political will to do something about it seems to be shriveling."
"If we keep on with business as usual, the Earth will be warmed more every year; drought and floods both will be endemic; many more cities, provinces, and whole nations will be submerged beneath the waves—unless heroic worldwide engineering countermeasures are taken. In the longer run, still more dire consequences may follow, including the collapse of the West Antarctic ice sheet, its surge into the sea, a major global rise in sea level, and the inundation of almost all the coastal cities on the planet."
"It's hard to understand how “conservatives” could oppose safeguarding the environment—that all of us including conservatives and their children—depend on for our very lives. What exactly is it conservatives are conserving?"
"We are ignorant about the complex mutual dependencies of the beings on earth, and what the sequential consequences will be if we wipe out some especially vulnerable microbes on which larger organisms depend. We are tugging at a planetwide biological tapestry and do not know whether one thread only will come out in our hands, or whether the whole tapestry will unravel before us."
"Nearly all our problems are made by humans and can be solved by humans. No social convention, no political system, no economic hypothesis, no religious dogma is more important."
"The inhibitions placed on the irresponsible use of technology are weak, often half-hearted, and almost always, worldwide, subordinated to short-term national or corporate interest. We are now able, intentionally or inadvertently, to alter the global environment. Just how far along we are in working the various prophesied planetary catastrophes is still a matter of scholarly debate. But that we are able to do so is now beyond question."
"If we are not graced with an instinctive knowledge of how to make our technologized world a safe and balanced ecosystem, we must figure out how to do it. We need more scientific research and more technological restraint. It is probably too much to hope that some great Ecosystem Keeper in the sky will reach down and put right our environmental abuses. It is up to us. It should not be impossibly difficult. Birds—whose intelligence we tend to malign—know not to defile the nest. Shrimps with brains the size of lint particles know it. Algae know it. One-celled microorganisms know it. It is time for us to know it too."
"The laws of physics suffice, without supernatural intervention."