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April 10, 2026
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"Early in life, as a witness to the limitless tragedy of World War I, I felt grow in me a determination to act, to work with others to influence the course of history and not supinely to accept what, in the absence of will and action, might be the world's fate. I came to Washington in the summer of 1940 with Jim Forrestal. I have been here, with short exceptions, ever since. For almost five decades I have played some role in the affairs of state, working with others to bend what otherwise might have been called the "inevitable trends of history." Some of the outcomes were wholly satisfactory, some marginally successful, and some were failures-but, on the whole, they were better, I think, than would otherwise have come about. On balance, we were fortunate in the opportunities for significant action the fortune of history opened up for us. It cannot be the good fortune of all mankind to live in Athens under the leadership of a Pericles, in Florence under the Medici, in the United States under a Washington or a Lincoln. Nor is it the usual fate of mankind to live under a Cleon, a Nero, a Stalin or a Hitler and thus have an unambiguous case for withdrawal from government or opposition to it. The usual case is a mixed one in which the task of the man of general wisdom and with a taste for politics is to manage, to deal with, to nudge the existing situation toward the best that is within the realm of the politically possible, to find such scope as he can for his courage, his fortitude, and his willingness to view facts with an open mind. When given half a chance, the combination of courage and an open mind can do wonders."
"The problems and opportunities facing the present and coming generations are no less, perhaps greater, than those we faced. I hope that some of our experiences may provide insights useful to them. In any case I am grateful to have had the good luck to participate in the history of a fateful era."
"I have often asked myself: âWhy has Jesus let all of this happen?â The only answer that comes to mind is that Jesus wants to manifest just how weak is the faith of many within the Church, even among too many of her bishops. Ironically, your pontificate has given those who hold harmful theological and pastoral views the license and confidence to come into the light and expose their previously hidden darkness. In recognizing this darkness, the Church will humbly need to renew herself, and so continue to grow in holiness."
"Think of life as being this book, an unfinished book for sure. We're just seeing the last few pages of each chapter. If you look out on the eight million species that we share this planet with, think of them all being four billion years of evolution. They're all the product of that. Think of us all as young leaves on this ancient and gigantic tree of life, all of us connected by invisible branches not just to each other, but to our extinct relatives and our evolutionary ancestors. As a biologist, I'm still trying to learn, with others, how everyone's related to each other, who is related to whom. Perhaps it's better still to think of us as a little fish out of water. Yes, one that learned to walk and talk, but one that still has a lot of learning to do about who we are and where we came from."
"Ichthyology, the study of fishes. It looks like a big, boring word, but it's actually quite exciting, because ichthyology is the only "ology" with "YOLO" in it. Now, to the cool kids in the audience, you already know, YOLO stands for "you only live once," and because I only have one life, I'm going to spend it doing what I always dreamt of doing: seeing the hidden wonders of the world and discovering new species. And that's what I get to do."
"One could rightly say that I became a Catholic by default, and that possibility is the simple gift I received from the Catholic Church. Mater ecclesia, she needed neither reasons, nor theories, nor ideas from me."
"Perhaps the secularization of our universities helps explain the tremors in public life. If one does not believe in God as Lord of history, then everything is up to us. This tempts us to fight with an almost religious desperation. Every election becomes a Final Judgment. Our preferred candidates take on religious roles as prophets and saviors. A purely secular outlook can also tempt us to give up the fight. Without confidence in Godâs providential care, we can despair of ever setting things aright. So we retreat into our private concerns, neglect the common good, and just try to gain enough wealth and status to insulate ourselves from the uncertainties of life. First Things has a crucial role to play. We insist that God is Lord of history. This desacralizes politicsâan urgent necessity. And it combats the hopelessness that often causes us to shrink from our civic duty, which at this particular juncture calls for the pluck to stand up to defend the sanctity of life, the dignity of marriage, the integrity of Western civilization, and the indispensable role of religion in public life."
"How do we interact with life delicately? Because we're entering a new age of exploration, where we have to take great care, and we have to set examples how we explore. So I've teamed up with roboticist Rob Wood at Harvard University, and we've been designing squishy underwater robot fingers, so we can delicately interact with the marine life down there. The idea is that most of our technologies to explore the deep ocean come from oil and gas and military, who, you know, they're not really caring to be gentle."
"I turned. The schoolground seemed to be glowing. It wasn't like night so much as like night on some high-tech movie set. Invisible machines operated everywhere. Hidden technicians monitored, taped, replayed and edited. Truth could be collapsed and disarranged. Life was not fact, but montage. I might even be an actor playing somebody else's role. My mind might be a stage upon which some cultural drama played."
"The body, I have often thought, is like a promise. You keep things in it. Those things are covert, immediate, yours. There is something lustrous about them. They emit energy, like radium or appliances. They can be replaced, repaired or simply discarded. The promise of the body is very firm and intact. It's the only promise we can count on, and we can't really count on it very much."
"He opened another beer, and I warmed some canned chili on the stove. Pedro ate most of it, sponging up the red chili sauce with slices of his doughy Wonderbread. "This is a hard fast world we live in, kiddoâand I'm telling you this as a friend, now. All this teary-eyed feeling sorry for yourself childhood crap just doesn't workâdoesn't work for long, anyway. I can promise you that. I mean, your mom wants you to have this idyllic childhood and all. She thinks this is Camelot or something, your childhood. Well, I want you to know, kiddo. I looked up 'idyllic' in the dictionary and I wouldn't hold my breath. I wouldn't lie in bed all day just waiting for some idyllic childhood to come along.""
"Sometimes I don't know," Rodney said, wiping his brow with the back of his greasy hand. "Sometimes I don't know if I was born mean, or if the world just made me that way."
"You know what Christmas means? It means if I love you, I'm going to buy you a whole load of crap. The more I love you, the bigger the load gets. Sometimes, if you can afford it, you can get your loved one literally tons of crap, and then they're really loved. Love, love, love. Ho ho ho. Merry Christmas. Buy some more crap. Come on, line up and buy yourselves a whole lot more crap. Here's something nice. Bought any crap quite like this crap recently? Crap crap crap. Ho ho ho. Like that mechanical Santa Claus in the Montgomery Ward's window display. Ho ho ho. Merry Christmas, everybody. Have yourselves all one fucking hell of a merry little Christmas, all you poor stupid saps. Line up and get taken, that's what I say, that's what Santa says. We take MasterCard cards and Visa cards. Come on, losers. Line up on this side. Get your money taken on that side."
"Because of the questions posed by SchrĂśdinger and the nature of the problem of identifying and describing the gene itself, the early development of molecular biology relied greatly on scientists who brought insights from physics to biologyâMax DelbrĂźck, Salvador Luria, George Gamow, Sir Lawrence Bragg, Francis Crick, Max Perutz, John Kendrew, Maurice Wilkins, Desmond Bernal, and Linus Pauling being the best known of these scientists."
"The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution."
"Living cells respond to DNA damage by a variety of mechanisms, including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases, called base excision repair, mismatch repair and nucleotide excision repair (NER). NER in human cells is a complex biochemical process during which a large multiprotein complex is assembled at several types of base damage. This multiprotein complex (NER machine) catalyses the excision of damaged bases as oligonucleotide fragments."
"It's shocking. It's horrible. The United States really has done remarkably badly compared to other countries (in dealing with COVID-19 pandemic). I mean, remarkably badly."
"The current popular literature about transsexualism is noteworthy for its ignorance of the distinction between autogynephilic and homosexual transsexuals."
"In order for a feminine boy to become transsexual, something extra must happen. What is the something extra?"
"Autogynephilic transsexuals are not "women in men's bodies" (Anne Lawrence, a physician and sex researcher who is herself a postoperative transsexual, has called them "men trapped in men's bodies")."
"Once you've learned about autogynephilic and homosexual transsexuals and seen several of each, distinguishing them is easy."
"The contention that homosexual orientation (as distinct from homosexual behavior) is a recent and local phenomenon is not supported by the evidence. Men who look awfully similar to the men Iâve been talking about in previous chapters seem to have existed through the ages and in vastly different cultures. Social constructionistsâ refusal or inability to see this suggests that they are trying to keep their eyes closed."
"The fact is that we don't know enough about hormonal effects on the human brain to have a very specific theory of how Danny's brain could have developed in a feminine direction while his body developed masculine. If Danny's body also showed signs of feminine development, this would support nature theory, but the lack of anatomical femininity does not disprove it. There has been essentially no research on boys like Danny that is directly biological. Short of dissecting the brain of a feminine boy and comparing it with normal boys' and girls' brains, it is unclear what we would even look for. However, the best conceivable direct test of nurture theory has been tried, and it failed. Amanda became Jason again."
"To me, cases like that really scream out, âHey, itâs not out there. Itâs in here.â Thereâs no indication that this mother is prone to raise very feminine boys because his twin is not that way."
"The two types of transsexuals who begin life as males are called homosexual and autogynephilic ... homosexual transsexuals are extremely feminine gay men, and autogynephilic transsexuals are men erotically obsessed with the image of themselves as women."
"Nobody ever gave Danny Ryan a dress before he asked for one, and he was punished much more than rewarded for his gender nonconformity. If he grows up to be a gay man, as I expect he will, it will be despite the most obvious influences in his social environment, not because of them. In the short term, Danny will receive no more encouragement from others to become gay than he did to wear dresses. Behavior that emerges with no encouragement, and despite opposition, is the sine qua non of innateness. Boys like Danny are poster children for biological influences on gender and sexuality, and this is true whether or not we measure a single biological marker."
"...femininity in boys and homosexuality in men are probably caused by incomplete masculinization of the brain during sexual differentiation."
"Another environmental hypothesis that has received some enthusiasm on the political right is the idea that gay people seduce and recruit. I have never understood how this is plausible. A boy with no interest in homosexual activity wouldn't find it pleasant even if he agreed to it. How is this supposed to turn him gay?"
"The bad trend is that scientists and laypeople both think that there is something more impressive about biological markersâa trait that one can measure with a ruler or a blood test or complicated electronic equipment (I'm serious, there is no better definition of âbiological markerâ)âthan there is about psychological or behavioral markers. This is a mistake."
"âSocial constructionismâ (or âsocial constructivismâ) is a term that might be familiar to anyone who has taken a humanities course at an American or European university since 1990, but it might otherwise sound odd. It is difficult to explain social constructionism in a way that satisfies social constructionists. They think this is because they are profound and people like me simplistic. I think it is because they aren't very clear, and to the extent they are clear, they are incorrect."
"Do I dislike sexual minorities? Enjoy hurting their feelings? Want to return us to our Puritanical past? If not, why have I repeatedly offended so many in these groups? My answers are ânoâ, ânoâ, ânoâ, and âbecause I try to do good scienceâ."
"When they leave prison, men who had been heterosexual before entering usually return to a strictly heterosexual lifestyle. Their prison encounters did not indicate that their sexual preference had changed. The men were simply doing the best they could, given constraints. It would be important to know what these men were thinking when they were having their penises sucked by other men, for example. Were they thinking of the men sucking their penises, or were they imagining their girlfriends at home? The former possibility would indicate more flexibility of true sexual preference than the latter."
"Homosexuality might be the most striking unresolved paradox of human evolution."
"When most people hear âenvironment,â they automatically think of the social environment, such as how children are raised or what kind of interpersonal experiences they have. But to a geneticist âenvironmentâ means anything not encoded in DNA, and this includes biological factors as well as social factors: diet, germs, and random biological events might also affect development. For example, when one identical twin is born with a major brain defect such as anencephaly (lack of a cerebral cortex, or outer brain) or microcephaly (a very small cortex), the other twin is usually normal. Only environment can cause identical twins to differ, but the environmental problem in this case is biological."
"Mass killing permeates history in multiple ways. It resides in our consciousness, just as we are products of this history. Not only that, we are all capable of participating in genocide. Itâs very important to understand, I think, that we are not immune to genocidal behavior. It is part of living in human society, and it is especially an available mode of human action when times are economically bad and peoples are at war."
". . . Euro-American Selves and Indian Others have not simply interacted as entities that remain fundamentally the same. They have dialectically constituted one another. Once one realizes the truth of this, he or she will begin to see that India has played a part in the making of nineteenth and twentieth-century Europe (and America) much greater than the "we" of scholarship, journalism, and officialdom would normally wish to allow. The subcontinent was not simply a source of colonial riches or a stage-setting in which Western hunters could stalk tigers, the sons of British merchants and aristocrats could make a financial killing, or the spiritualist find his or her innermost soul (or its Buddhist absence). More than that, India was (and to some extent still is) the object of thoughts and acts with which this "we" has constituted itself."
"The first phase of the Muslim conquest of North India was a splendid ghazi adventure of looting, shooting, and smashing up the gods of Hindu idolators. The new kings of Dehli, however, imposed civil order on the conquered areas and created a structure of despotism designed to tax rather than slaughter the native peasantry."
"Independence governments implemented secularism mostly by refusing to recognize the religious pasts of Indian nationalism, whether Hindu or Muslim, and at the same time (inconsistently) by retaining Muslim 'personal law' ."
"We have a system of justice in this country that treats you much better if you're rich and guilty than if you're poor and innocent. Wealth, not culpability, shapes outcomes."
"We should not be misled by this into thinking that these scholars were anti-racist. They did not have to rely on a theory of race as such, for they had their own global theory that was fully able to inferiorize the languages (and by implication the cultures) of the other purely on linguistic grounds. Max MĂźller's linguistic taxonomy was a Hegelian hierarchy in which . . . cultural geography [becomes] the same as world history."
"The most important shift, especially in South Asia, has been the rise to prominence of scholarship that returns not to Hegel but to Marx. (154-5)"
"It's interesting, this question of the death penalty. In many ways, we've been taught to think that the real question is, do people deserve to die for the crimes they've committed? And that's a very sensible question. But there's another way of thinking about where we are in our identity. The other way of thinking about it is not, do people deserve to die for the crimes they commit, but do we deserve to kill?"
"Throughout this book I have argued¡ that. the problem with orientalism is not just one of bias or o( bad motives and hence, confined to itself. The problem lies in my view, with the way in which the human sciences have displaced human agency on to essences in the first place. Taking up some leads of Collingwood, I have tried to show how an alternative approach that focuses on human agency might be constructed, and how it might be used, as a vantage point from which both to criticize previous scholarship and to reconstruct our knowledges of the human world. (264)"
"By 1915, this attitude was changing. I refer to a legal ruling against Arya Samaj preacher Dharm Bir,who was found guilty under Section 298 of âusing offensive phrases and gestures... with the deliberate intention of wounding the religious feelingsâ of the Muslims present in his audience, and under Section 153, for âwantonly provoking the riot which subsequently occurred.â.. Dharm Bir had delivered a public lecture critical of Islam, following which a group of Muslims beat up several Arya Samaj lecturers. Ten Muslims were convicted for rioting, but it was felt that something must be done to punish Dharm Bir and the Arya Samaj. The Arya Samaj was charged, and a judge was brought in who could assure conviction... Winning the case against Dharm Bir required a new position on religious controversy. The judge found it by condemning not only the tone of Dharm Birâs language, but religious debate itself, when he declared, âlogic has never been known to convert any oneâ; Dharm Bir âdoes not know that logic has never saved a soul and that religion is rooted in the emotions and sentimentsâ. Because religion is ârooted in the sentiments,â the judge concluded, religious debate is likely to provoke a riot, and that is all it can do. Religious debate is pointless and therefore unjustifiable; the right publicly to controvert arguments therefore does not properly extend to religion. To enter into religious debate is nothing but a provocation, an act calculated to arouse hatred. Therefore, it is intolerable."
"In 1927, section 295A was enacted to extend the ease with which âwounding religious feelingsâ by verbal acts could be prosecuted. The purpose was to curb religious violence by curbing provocative speech. But the strategic field the law put into place worked differently: it extended the strategic value of demonstrating that passions had been aroused that threatened the public peace, in order to induce the government to take legal action against oneâs opponents. Section 295A thus gave a fillip to the politics of religious sentiment."
"In India, the notion that to be truly tolerant in religion is to refrain from criticism of religion is a widespread secularist ideal. But this ideal has long been conjoined with the assumption that the party criticized will be unable to contain violent reaction. One result has been to give strategic value to violence as a way of proving the point."
"This amendment to the Indian Penal Code was coupled with an emerging understanding of religion as rooted exclusively in sentiment."
"If institutional indeterminacy pervaded the post-nomadic empires of Hind, the peripatetic exercise of power was another feature which they all seem to have shared. Muhammad bin Tughluq spent the greater part of his life in military camps. Most other rulers were often on campaign, sometimes for one or two years, or more, particularly in the late thirteenth and fourteenth centuries, when com munications could be broken off with the capital for months or a whole year. Firuz Shah Tughluq stayed away on a campaign to Bengal and Orissa for two years and seven months, losing his way on the return journey through jungles and mountains, when for six months there was no news from him and the viceregent had great difficulty keeping things under control. The same Sultan got lost in the Rann of Cutch, and was again cut off from Delhi for six months, altogether spending two-and-a-half years on the trip, while the viceregent pretended he had good news."
"The association of sentiment and violence enshrined in section 295A was not only a product of concerns with law and order; it was also the result of a critical view of religious proselytizing. Section 295A was intended to provide a legal tool to restrain the religious criticism associated with proselytizing by the Arya Samaj."
"When coordinated acts of violence are justified as the inevitable result of hurt feelings, legal precautions against violent displays of religious passion may be said to have backfired."