Chemists from the United States

"We have a word game in English called "Twenty questions." To play Twenty Questions, one player imagines some object, and the other players must guess what it is by asking questions that can be answered with a "yes" or a "no." I imagine every language has a similar game, and, for those of us who speak the language of science, the game is called The Scientific Method."

"...when I started doing chemistry, I did it the way I fished – for the excitement, the discovery, the adventure, for going after the most elusive catch imaginable in uncharted seas."

"Chemists usually write about their chemical careers in terms of the different areas and the discrete projects in those areas on which they have worked. Essentially all my chemical investigations, however, are in only one area, and I tend to view my research not with respect to projects, but with respect to where I’ve been driven by two passions which I acquired in graduate school: I am passionate about the Periodic Table (and selenium, titanium and osmium are absolutely thrilling), and I am passionate about catalysis. What the ocean was to the child, the Periodic Table is to the chemist; new catalytic reactivity is, of course, my personal coelacanth."

"The discipline, nonetheless, is exacting: everything that can be observed should be observed, even if it is only recalled as the bland background from which the intriguing bits pop out like Venus in the evening sky. The goal is always finding something new, hopefully unimagined and, better still, hitherto unimaginable."

"A substance showing resonance between two or more valence-bond structures does not contain molecules with the configurations and properties usually associated with these structures."

"Science cannot be stopped. Man will gather knowledge no matter what the consequences – and we cannot predict what they will be. Science will go on — whether we are pessimistic, or are optimistic, as I am. I know that great, interesting, and valuable discoveries can be made and will be made… But I know also that still more interesting discoveries will be made that I have not the imagination to describe — and I am awaiting them, full of curiosity and enthusiasm."

"We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine."

"We must not have a Nuclear war. We must begin to solve international disputes by the application of man's power of reason in a way that is worthy of the dignity of man. We must solve them by arbitration, negotiation, and the development of international law, the making of international agreements that will do justice to all nations and to all peoples and will benefit all nations and to all people. Now is the time to start."

"Planck’s constant and the quantum theory that is built around it are of extreme importance for chemistry—we may well be justified in saying that quantum theory is of greater importance to chemistry than to physics ... there is no part of chemistry that does not depend, in its fundamental theory, upon quantum principles."

"The power to destroy the world by the use of nuclear weapons is a power that cannot be used - we cannot accept the idea of such monstrous immorality.The time has now come for morality to take its proper place in the conduct of world affairs; the time has now come for the nations of the world to submit to the just regulation of their conduct by international law."

"The only sane policy for the world is that of abolishing war."

"Everyone should know that the "war on cancer" is largely a fraud, and that the National Cancer Institute and American Cancer Society are derelict in their duties to the people who support them."

"I realized that more and more I was saying, "It seems to me that we have come to the time war ought to be given up. It no longer makes sense to kill 20 million or 40 million people because of a dispute between two nations who are running things, or decisions made by the people who really are running things. It no longer makes sense. Nobody wins. Nobody benefits from destructive war of this sort and there is all of this human suffering." And Einstein was saying the same thing of course. So that is when we decided — my wife and I — that first, I was pretty effective as a speaker. Second, I better start boning up, studying these other fields so that nobody could stand up and say, "Well, the authorities say such and such ""

"I've been asked from time to time, "How does it happen that you have made so many discoveries? Are you smarter than other scientists?" And my answer has been that I am sure that I am not smarter than other scientists. I don't have any precise evaluation of my IQ, but to the extent that psychologists have said that my IQ is about 160, I recognize that there are one hundred thousand or more people in the United States that have IQs higher than that. So I have said that I think I think harder, think more than other people do, than other scientists. That is, for years, almost all of my thinking was about science and scientific problems that I was interested in."

"As far as women are concerned, I am old-fashioned enough to like the idea of a woman's managing the household. This is an important activity. A woman does not have to be a bank vice-president to find happiness. I should think routine work like sitting at a desk writing letters, making reports, or punching data into computers would be much less interesting and satisfying than running a home."

"If you want to have good ideas you must have many ideas. Most of them will be wrong, and what you have to learn is which ones to throw away."

"I have always wanted to know as much as possible about the world."

"Only when I began studying chemical engineering at Oregon Agricultural College did I realize that I myself might discover something new about the nature of the world."

"When an old and distinguished person speaks to you, listen to him carefully and with respect — but do not believe him. Never put your trust into anything but your own intellect. Your elder, no matter whether he has gray hair or has lost his hair, no matter whether he is a Nobel laureate — may be wrong. The world progresses, year by year, century by century, as the members of the younger generation find out what was wrong among the things that their elders said. So you must always be skeptical — always think for yourself."

"What astonished me was the very low toxicity of a substance that has such very great physiological power. A little pinch, 5 mg, every day, is enough to keep a person from dying of pellagra, but it is so lacking in toxicity that ten thousand times as much can be taken without harm."

"I have something that I call my Golden Rule. It goes something like this: "Do unto others twenty-five percent better than you expect them to do unto you." … The twenty-five percent is for error."

"Just think of the differences today. A young person gets interested in chemistry and is given a chemical set. But it doesn't contain potassium cyanide. It doesn't even contain copper sulfate or anything else interesting because all the interesting chemicals are considered dangerous substances. Therefore, these budding young chemists don't get a chance to do anything engrossing with their chemistry sets. As I look back, I think it is pretty remarkable that Mr. Ziegler, this friend of the family, would have so easily turned over one-third of an ounce of potassium cyanide to me, an eleven-year-old boy."

"He combined scientific brilliance, political courage, and a stubborn, quirky single-mindedness in ways that... will probably always resist simple explanation."

"Linus Pauling was not always right in his ideas. But my belief is that, in most cases, if somebody is always right in his ideas you find that he does not have much to say. It is an expression of somebody's fertility that he does produce quite a number of ideas, and I think Linus Pauling's score is pretty high... I do not think, as I said earlier, that it is right to discuss the impact of Linus Pauling on molecular biology. Rather, he was one of the founders of molecular biology. It was not that it existed in some way, and he simply made a contribution. He was one of the founders who got the whole discipline going."

"Whatever the context and whatever the audience, he was clear, he was committed, he was compassionate, and, far more often than most, he was right — or if not, at least on the side of the angels."

"If there is a need for a universal hero, it is easy to see why Linus Pauling would be nominated for the role. In many ways he seemed larger than life."

"While still in his twenties, he became a world famous scientist... His work in chemical biology, done during the middle years of his life, was almost equally outstanding... Pauling was also acclaimed for his activism as a citizen, although his activities were controversial."

"He used his scientific credentials to challenge the government's claims that fallout from nuclear testing was not harmful."

"The right wing of the 1950s denounced Pauling as a Communist, or at the least a fellow traveler. Pauling and his wife were, in fact, openly active in several organizations dominated by Soviet sympathizers, as well as dozens of others. But they were never apologists for the Soviet party line, or any other organizational dogma, nor did Pauling refrain from challenging the Soviets when he thought them wrong."

"Then, at the peak of his prestige and renown, instead of settling into a comfortable elder statesman role, Pauling shocked his friends and admirers by launching a crusade to prove that vitamin C would cure the common cold... While Pauling quickly recognized his error on DNA, accept­ing it as the kind of mistake any scientist can make and more or less dis­carding his previous ideas about vitamin treatment of schizophrenia, he never abandoned his claims about vitamin C and the treatment of cancer, and in the last years of his life he felt vindicated when a national medical conference gave him a standing ovation, claiming that "Pauling was right all along.""

"Pauling was not superhuman, but he was a very great man, with an extraordinarily sharp and creative mind, a firm inner determination, and a strong moral sense. His life holds many lessons and poses many intriguing questions for all of us."

"Pauling scooped out a hollow on the narrow ledge and covered himself with a big map he carried in his pocket. He dared not sleep because of the cold. He counted in French and German and Italian to keep himself awake; he exercised as he lay in his narrow quarters. He told the unheeding ocean about the nature of the chemical bond. When the stars came out, he sighted the end of his walking stick and tried to tell time by the constellations. He recited the periodic table of the elements. He grew more and more anxious, not for himself, since he knew he would eventually be found, but for Ava Helen, whom he could not tell that he was uncomfortable, but unharmed. He was chagrined by his predicament…."

"Linus Pauling undoubtedly stands as one of the most influential scientists of the twentieth century."

"Although Pauling was often controversial and was sometimes criticized in both scientific and political arenas, it is incontrovertible that he had a major impact on science, education, and international peace."

"As my father's son I am certainly among his fondest admirers. Now I have ample evidence that all over the nation, and elsewhere in the world, innumerable people share my affection and admiration in their own ways. They not only admire but love him. They have read his books and articles, have seen him on television, have attended meetings where he spoke, or by chance sat next to him at a banquet or on the airplane. A number have received personal messages from him or talked with him over the phone. They feel a personal connection, a strong bond, with his values-his valiant anti-nuclear-testing stance, his dedication to world peace, his emphasis on vitamin C as a valuable nutrient for both preven­tion and treatment of disease, his compassion for the human condition of suffering. For a number of our supporters, Linus Pauling may be the closest embodiment, in this age of uncertainty, amorality, and constant conflict, of a living universal hero."

"From time to time throughout his long life, scientists and commentators dismissed him as a showman. Would that we had a whole troupe of such scientific showmen."

"The esteem with which he was regarded was vividly illustrated to me in 1951 when, as a postdoctoral fellow of Pauling's, I visited Albert Einstein in Princeton. Einstein's comment to me was "Ah, that man is a real genius!""

"An extraordinary person — a scientist, educator, humanist, and statesman with worldwide impact in each of these roles."

"In spite of our advances... there is no scientific evidence that can convince... more potently than a sincere and emotional testimonial. Such... does not always come from the regular guy... Linus Pauling... was said to believe in vitamin C's medicinal properties, himself ingesting massive doses. With his bully pulpit, he contributed to the common belief in vitamin C's curative properties. Many medical studies, unable to replicate Pauling's claims, fell on dear ears as it was difficult to undo the testimonial by a "Nobel Prize winner," even if he was not qualified to discuss matters related to medicine."

"If we stay strong, then I believe we can stabilize the world and have peace based on force. Now, peace based on force is not as good as peace based on agreement, but in the terrible world in which we live, in the world where the Russians have enslaved many millions of human beings, in the world where they have killed men, I think that for the time being the only peace we can have is the peace based on force. Furthermore, I do not think that this peace based on force is, can be, or should be, an ultimate end. Our ultimate end must be precisely what Dr. Pauling says, peace based on agreement, on understanding, on universally agreed and enforced law. I think this is a wonderful idea, but peace based on force buys the necessary time, and in this time we can work for better understanding, for closer collaboration, first with the countries which are closest to us, which we understand better, our allies, the western countries, the NATO countries, which believe in human liberties as we do. Then, as soon as possible, with the rest of the free world, and eventually, I hope, with the whole world, including Russia, even though it may take many years to come."

"I don't want to kill anybody. I am passionately opposed to killing, but I'm even more passionately fond of freedom. The freedom of Dr. Pauling and of myself expressing our opinions freely on any subject, however broad, however far removed of our proper competence, but particularly, to be able to express our opinions in the fields we really know; this would not be possible in Russia."

"... Particularly important were the exact arguments needed to understand how Linus Pauling had discovered the . I soon was taught that Pauling's accomplishment was a product of common sense, not the result of complicated mathematical reasoning. Equations occasionally crept into his argument, but in most cases words would have sufficed. The key to Linus' success was his reliance on the simple laws of . The α-helix had not been found by only staring at X-ray pictures; the essential trick, instead, was to ask which atoms like to sit next to each other. In place of pencil and paper, the main working tools were a set of molecular models superficially resembling the toys of preschool children."

"The need for general scientific understanding by the public has never been larger, and the penalty for scientific illiteracy never harsher… Lack of scientific fundamentals causes people to make foolish decisions about issues such as the toxicity of chemicals, the efficacy of medicines, the changes in the global climate."

"Our single greatest defense against scientific ignorance is education, and early in the life of every scientist, the child's first interest was sparked by a teacher."

"True science is distinctively the study of useless things. For the useful things will get studied without the aid of scientific men."

"The Scientific Attitude and Fallibilism in Philosophical Writings of Peirce, selected and edited with an introducton by Justus Buchler. p. 49"

"Few persons care to study logic, because everybody conceives himself to be proficient enough in the art of reasoning already. But I observe that this satisfaction is limited to one's own ratiocination and does not extend to that of other men. We come to the full possession of our power of drawing inferences the last of all our faculties, for it is not so much a natural gift as a long and difficult art."

"The Protestant churches generally hold that the elements of the sacrament are flesh and blood only in a tropical sense; they nourish our souls as meat and the juice of it would our bodies. But the Catholics maintain that they are literally just that; although they possess all the sensible qualities of wafer-cakes and diluted wine. But we can have no conception of wine except what may enter into a belief, either —"

"It is terrible to see how a single unclear idea, a single formula without meaning, lurking in a young man’s head, will sometimes act like an obstruction … in an artery, hindering the nutrition of the brain, and condemning its victim to pine away in the fullness of his intellectual vigor and in the midst of intellectual plenty."

"The consciousness of a general idea has a certain "unity of the ego" in it, which is identical when it passes from one mind to another. It is, therefore, quite analogous to a person, and indeed, a person is only a particular kind of general idea."

"It is the man of science, eager to have his every opinion regenerated, his every idea rationalized, by drinking at the fountain of fact, and devoting all the energies of his life to the cult of truth, not as he understands it, but as he does not yet understand it, that ought properly to be called a philosopher. To an earlier age knowledge was power — merely that and nothing more; to us it is life and the summum bonum. Emancipation from the bonds of self, of one's own prepossessions, importunately sought at the hands of that rational power before which all must ultimately bow, — this is the characteristic that distinguishes all the great figures of nineteenth-century science from those of former periods."

"You are of all my friends the one who illustrates pragmatism in its most needful forms. You are a jewel of pragmatism."

"It is important to understand what I mean by semiosis. All dynamic action, or action of brute force, physical or psychical, either takes place between two subjects, — whether they react equally upon each other, or one is agent and the other patient, entirely or partially, — or at any rate is a resultant of such actions between pairs. But by "semiosis" I mean, on the contrary, an action, or influence, which is, or involves, a cooperation of three subjects, such as a sign, its object, and its interpretant, this tri-relative influence not being in any way resolvable into actions between pairs."

"I define a Sign as anything which is so determined by something else, called its Object, and so determines an effect upon a person, which effect I call its Interpretant, that the latter is thereby mediately determined by the former."

"It has never been in my power to study anything, — mathematics, ethics, metaphysics, gravitation, thermodynamics, optics, chemistry, comparative anatomy, astronomy, psychology, phonetics, economics, the history of science, whist, men and women, wine, metrology, except as a study of semeiotic."

"The definition of definition is at bottom just what the maxim of pragmatism expresses."

"By an object, I mean anything that we can think, i.e. anything we can talk about."

"The entire universe is perfused with signs, if it is not composed exclusively of signs."

"Any character or proposition either concerns one subject, two subjects, or a plurality of subjects. For example, one particle has mass, two particles attract one another, a particle revolves about the line joining two others. A fact concerning two subjects is a dual character or relation; but a relation which is a mere combination of two independent facts concerning the two subjects may be called degenerate, just as two lines are called a degenerate conic. In like manner a plural character or conjoint relation is to be called degenerate if it is a mere compound of dual characters. A sign is in a conjoint relation to the thing denoted and to the mind. If this triple relation is not of a degenerate species, the sign is related to its object only in consequence of a mental association, and depends upon a habit. Such signs are always abstract and general, because habits are general rules to which the organism has become subjected. They are, for the most part, conventional or arbitrary. They include all general words, the main body of speech, and any mode of conveying a judgment. For the sake of brevity I will call them tokens."

"If the sign were not related to its object except by the mind thinking of them separately, it would not fulfil the function of a sign at all. Supposing, then, the relation of the sign to its object does not lie in a mental association, there must be a direct dual relation of the sign to its object independent of the mind using the sign. In the second of the three cases just spoken of, this dual relation is not degenerate, and the sign signifies its object solely by virtue of being really connected with it. Of this nature are all natural signs and physical symptoms. I call such a sign an index, a pointing finger being the type of the class. The index asserts nothing; it only says "There!" It takes hold of our eyes, as it were, and forcibly directs them to a particular object, and there it stops. Demonstrative and relative pronouns are nearly pure indices, because they denote things without describing them; so are the letters on a geometrical diagram, and the subscript numbers which in algebra distinguish one value from another without saying what those values are."

"I call a sign which stands for something merely because it resembles it, an icon. Icons are so completely substituted for their objects as hardly to be distinguished from them. Such are the diagrams of geometry. A diagram, indeed, so far as it has a general signification, is not a pure icon; but in the middle part of our reasonings we forget that abstractness in great measure, and the diagram is for us the very thing. So in contemplating a painting, there is a moment when we lose the consciousness that it is not the thing, the distinction of the real and the copy disappears, and it is for the moment a pure dream, — not any particular existence, and yet not general. At that moment we are contemplating an icon."

"I have taken pains to make my distinction of icons, indices, and tokens clear, in order to enunciate this proposition: in a perfect system of logical notation signs of these several kinds must all be employed. Without tokens there would be no generality in the statements, for they are the only general signs; and generality is essential to reasoning. … But tokens alone do not state what is the subject of discourse ; and this can, in fact, not be described in general terms ; it can only be indicated. The actual world cannot be distinguished from a world of imagination by any description. Hence the need of pronoun and indices, and the more complicated the subject the greater the need of them."

"Now, to say that a lot of objects is finite, is the same as to say that if we pass through the class from one to another we shall necessarily come round to one of those individuals already passed; that is, if every one of the lot is in any one-to-one relation to one of the lot, then to every one of the lot some one is in this same relation."

"As the mathematics are now understood, each branch — or, if you please, each problem, — is but the study of the relations of a collection of connected objects, without parts, without any distinctive characters, except their names or designating letters. These objects are commonly called points; but to remove all notion of space relations, it may be better to name them monads. The relations between these points are mere complications of two different kinds of elementary relations, which may be termed immediate connection and immediate non-connection. All the monads except as serve as intermediaries for the connections have distinctive designations."

"A pair of statements may be taken conjunctively or disjunctively; for example, "It lightens and it thunders," is conjunctive, "It lightens or it thunders" is disjunctive. Each such individual act of connecting a pair of statements is a new monad for the mathematician."

"Of the fifty or hundred systems of philosophy that have been advanced at different times of the world's history, perhaps the larger number have been, not so much results of historical evolution, as happy thoughts which have accidently occurred to their authors. An idea which has been found interesting and fruitful has been adopted, developed, and forced to yield explanations of all sorts of phenomena. … The remaining systems of philosophy have been of the nature of reforms, sometimes amounting to radical revolutions, suggested by certain difficulties which have been found to beset systems previouslv in vogue; and such ought certainly to be in large part the motive of any new theory. … When a man is about to build a house, what a power of thinking he has to do, before he can safely break ground! With what pains he has to excogitate the precise wants that are to be supplied. What a study to ascertain the most available and suitable materials, to determine the mode of construction to which those materials are best adapted, and to answer a hundred such questions! Now without riding the metaphor too far, I think we may safely say that the studies preliminary to the construction of a great theory should be at least as deliberate and thorough as those that are preliminary to the building of a dwelling-house."

"To suppose universal laws of nature capable of being apprehended by the mind and yet having no reason for their special forms, but standing inexplicable and irrational, is hardly a justifiable position. Uniformities are precisely the sort of facts that need to be accounted for. That a pitched coin should sometimes turn up heads and sometimes tails calls for no particular explanation; but if it shows heads every time, we wish to know how this result has been brought about. Law is par excellence the thing that wants a reason."

"The only possible way of accounting for the laws of nature and for uniformity in general is to suppose them results of evolution. This supposes them not to be absolute, not to be obeyed precisely. It makes an element of indeterminacy, spontaneity, or absolute chance in nature. Just as, when we attempt to verify any physical law, we find our observations cannot be precisely satisfied by it, and rightly attribute the discrepancy to errors of observation, so we must suppose far more minute discrepancies to exist owing to the imperfect cogency of the law itself, to a certain swerving of the facts from any definite formula."

"The one primary and fundamental law of mental action consists in a tendency to generalisation. Feeling tends to spread ; connections between feelings awaken feelings; neighboring feelings become assimilated; ideas are apt to reproduce themselves. These are so many formulations of the one law of the growth of mind. When a disturbance of feeling takes place, we have a consciousness of gain, the gain of experience; and a new disturbance will be apt to assimilate itself to the one that preceded it. Feelings, by being excited, become more easily excited, especially in the ways in which they have previously been excited. The consciousness of such a habit constitutes a general conception. The cloudiness of psychological notions may be corrected by connecting them with physiological conceptions. Feeling may be supposed to exist, wherever a nerve-cell is in an excited condition. The disturbance of feeling, or sense of reaction, accompanies the transmission of disturbance between nerve-cells or from a nerve-cell to a muscle-cell or the external stimulation of a nerve-cell. General conceptions arise upon the formation of habits in the nerve-matter, which are molecular changes consequent upon its activity and probably connected with its nutrition."

"The law of habit exhibits a striking contrast to all physical laws in the character of its commands. A physical law is absolute. What it requires is an exact relation. Thus, a physical force introduces into a motion a component motion to be combined with the rest by the parallelogram of forces; but the component motion must actually take place exactly as required by the law of force. On the other hand, no exact conformity is required by the mental law. Nay, exact conformity would be in downright conflict with the law ; since it would instantly crystallise thought and prevent all further formation of habit. The law of mind only makes a given feeling more likely to arise. It thus resembles the "non-conservative" forces of physics, such as viscosity and the like, which are due to statistical uniformities in the chance encounters of trillions of molecules."

"The old dualistic notion of mind and matter, so prominent in Cartesianism, as two radically different kinds of substance, will hardly find defenders to-day. Rejecting this, we are driven to some form of hylopathy, otherwise called monism."

"The one intelligible theory of the universe is that of objective idealism, that matter is effete mind, inveterate habits becoming physical laws. But before this can be accepted it must show itself capable of explaining the tridimensionality of space, the laws of motion, and the general characteristics of the universe, with mathematical clearness and precision ; for no less should be demanded of every Philosophy."

"Three conceptions are perpetually turning up at every point in every theory of logic, and in the most rounded systems they occur in connection with one another. They are conceptions so very broad and consequently indefinite that they are hard to seize and may be easily overlooked. I call them the conceptions of First, Second, Third. First is the conception of being or existing independent of anything else. Second is the conception of being relative to, the conception of reaction with, something else. Third is the conception of mediation, whereby a first and second are brought into relation."

"The origin of things, considered not as leading to anything, but in itself, contains the idea of First, the end of things that of Second, the process mediating between them that of Third. A philosophy which emphasises the idea of the One, is generally a dualistic philosophy in which the conception of Second receives exaggerated attention: for this One (though of course involving the idea of First) is always the other of a manifold which is not one. The idea of the Many, because variety is arbitrariness and arbitrariness is repudiation of any Secondness, has for its principal component the conception of First. In psychology Feeling is First, Sense of reaction Second, General conception Third, or mediation. In biology, the idea of arbitrary sporting is First, heredity is Second, the process whereby the accidental characters become fixed is Third. Chance is First, Law is Second, the tendency to take habits is Third. Mind is First, Matter is Second, Evolution is Third."

"May some future student go over this ground again, and have the leisure to give his results to the world."

"When I have asked thinking men what reason they had to believe that every fact in the universe is precisely determined by law, the first answer has usually been that the proposition is a "presupposition " or postulate of scientific reasoning. Well, if that is the best that can be said for it, the belief is doomed. Suppose it be " postulated " : that does not make it true, nor so much as afford the slightest rational motive for yielding it any credence. It is as if a man should come to borrow money, and when asked for his security, should reply he "postulated " the loan. To "postulate" a proposition is no more than to hope it is true. There are, indeed, practical emergencies in which we act upon assumptions of certain propositions as true, because if they are not so, it can make no difference how we act. But all such propositions I take to be hypotheses of individual facts. For it is manifest that no universal principle can in its universality be compromised in a special case or can be requisite for the validity of any ordinary inference."

"In an article published in The Monist for January, 1891, I endeavored to show what ideas ought to form the warp of a system of philosophy, and particularly emphasized that of absolute chance. In the number of April, 1892, I argued further in favor of that way of thinking, which it will be convenient to christen tychism (from τύχη, chance). A serious student of philosophy will be in no haste to accept or reject this doctrine; but he will see in it one of the chief attitudes which speculative thought may take, feeling that it is not for an individual, nor for an age, to pronounce upon a fundamental question of philosophy. That is a task for a whole era to work out. I have begun by showing that tychism must give birth to an evolutionary cosmology, in which all the regularities of nature and of mind are regarded as products of growth, and to a Schelling-fashioned idealism which holds matter to be mere specialized and partially deadened mind."

"The tendency to regard continuity, in the sense in which I shall define it, as an idea of prime importance in philosophy conveniently may be be termed synechism. The present paper is intended chiefly to show what synechism is, and what it leads to."

"Logical analysis applied to mental phenomenon shows that there is but one law of mind, namely that ideas tend to spread continuously and to affect certain others which stand to them in a peculiar relation of affectibility. In this spreading they lose intensity, and especially the power of affecting others, but gain generality and become welded with other ideas."

"We are accustomed to speak of ideas as reproduced, as passed from mind to mind, as similar or dissimilar to one another, and, in short, as if they were substantial things; nor can any reasonable objection be raised to such expressions. But taking the word "idea" in the sense of an event in an individual consciousness, it is clear that an idea once past is gone forever, and any supposed recurrence of it is another idea. These two ideas are not present in the same state of consciousness, and therefore cannot possibly be compared."

"What distinct meaning can attach to saying that an idea in the past in any way affects an idea in the future, from which it is completely detached?"

"We have here a question of difficulty, analogous to the question of nominalism and realism."

"Some minds will jump here jump to the conclusion that a past idea cannot in any sense be present. But that is hasty and illogical. How extravagant too, to pronounce our whole knowledge of the past to be mere delusion! Yet it would seem that the past is completely beyond the bounds of possible experience as a Kantian thing-in-itself."

"How can a past idea be present?... it can only be going, infinitesimally past, less past than any assignable past date. We are thus brought to the conclusion that the present is connected to the past by a series of real infinitesimal steps."

"If the sensation that precedes the present by half a second were still immediately before me, then on the same principle, the sensation preceding that would be immediately present, and so on ad infinitum. Now, since there is a time [period], say a year, at the end of which an idea is no longer ipso facto present, it follows that this is true of any finite interval, however short."

"Consciousness must essentially cover an interval of time; for if it did not, we could gain no knowledge of time, and not merely no veracious cognition of it, but no conception whatever. We are therefore, forced to say that we are immediately conscious through an infinitesimal interval of time."

"In fact, this infinitesimally spread-out consciousness is a direct feeling of its contents as spread out. In an infinitesimal interval we directly perceive the temporal sequence of its beginning, middle, and end... Now upon this interval follows another, whose beginning is the middle of the former, and whose middle is the end of the former. Here we have an immediate perception of the temporal sequence of its beginning, middle and end, or say, of the second, third, and fourth instants."

"From these two immediate perceptions, we gain a mediate, or inferential perception of the relation of all four instants. This mediate perception is objectively, or as to the object being represented, spread over the four instants; but subjectively, or as itself the subject of duration, it is completely embraced in the second moment. (The reader will observe that I use the word instant to mean a point in time, and moment to mean an infinitesimal duration."

"Now, let there be an indefinite succession of these inferential acts of comparative perception; and it is plain that the last moment will contain objectively the whole series. Let there be, not merely an indefinite succession, but a continuous flow of inference through a finite time; and the result will be a mediate objective consciousness of the whole time in the last moment. In this last moment, the whole series will be recognized, or known as known before."

"Indeed, even this last moment will be recognized like the rest, at least, be just beginning to be so."

"Suppose a surface to be part red and part blue; so that every point on it is either red or blue, and of course, no part can be both red and blue. What then, is the color of the surface in the immediate neighborhood of the point. ...it follows that the boundary is half red and half blue. In like manner, we find it necessary to hold that consciousness essentially occupies time... Thus, the present is half past and half time to come. ...Take another case: the velocity of a particle at any instant of time is its mean velocity during an infinitesimal instant in which that time is consumed. Just so, my immediate feeling is my feeling through an infinitesimal duration containing the present instant."

"One of the most marked features about the law of mind is that it makes time to have a definite direction of flow from past to future. ...This makes one of the great contrasts between the law of mind and the law of physical force, where there is no more distinction between the two opposite directions in time than between moving northward and moving southward."

"Time with its continuity logically involves some other kind of continuity than its own. Time, as the universal form of change, cannot exist unless there is something to undergo change, and to undergo a change continuous in time, there must be a continuity of changeable qualities."

"The development of the human mind has practically extinguished all feelings, except a few sporadic kinds, [like] sound, colors, smells, warmth, etc., which now appear to be disconnected and separate."

"In the case of colors, there is a tridimensional spread of feelings. Originally all feelings may have been connected in the same way, and the presumption is that the number of dimensions was endless. For development essentially involves a limitation of possibilities. But given a number of dimensions of feeling, all possible varieties are obtainable by varying the intensities of the different elements."

"Accordingly, time logically supposes a continuous range of intensity of feeling. It follows then, from the definition of continuity, that when any particular kind of feeling is present, an infinitesimal continuum of all feelings differing infinitesimally from that, is present."

"Since space is continuous, it follows that there must be an immediate community of feeling between parts of mind infinitesimally close together. Without this, I believe it would have been impossible for any co-ordination to be established in the action of the nerve-matter of one brain."

"A finite interval of time generally contains an innumerable series of feelings; and when these become welded together in association the result is a general idea."

"The first character of a general idea so resulting is that it is living feeling. A continuum of this feeling, infinitesimal in duration, but still embracing innumerable parts, and also, though infinitesimal, entirely unlimited, is immediately present. And in its absence of boundedness a vague possibility of more than is present is directly felt."

"Second, in the presence of this continuity of feeling, nominalistic maxims appear futile. There is no doubt about one idea affecting another, when we can directly perceive the one generally modified and shaping itself into the other. Nor can there any longer be any difficulty about one idea resembling another, when we can pass along the continuous field of quality from one to the other and back again to the point which we had marked."

"Third, consider the insistency of an idea. The insistency of a past idea with reference to the present is a quantity which is less, the further back that past idea is, and rises to infinity as the past idea is brought up into coincidence with the present."

"Here we must make one of those inductive applications of the law of continuity which have produced such great results in all of the positive sciences. We must extend the law of insistency into the future. Plainly, the insistency of a future idea with reference to the present is a quantity affected by the minus sign; for it is the present that affects the future, if there be any effect, not the future that affects the present."

"Feeling which has not yet emerged into immediate consciousness is already affectible and already affected. In fact, this is habit, by virtue of which an idea is brought up into the present consciousness by a bond that has already been established between it and another idea while it was still in futuro."

"Wherever ideas come together they tend to weld into general ideas; and whenever they are generally connected, general ideas govern the connection; and these general ideas are living feelings spread out."

"In deduction the mind is under the dominion of a habit or association by virtue of which a general idea suggests in each case a corresponding reaction. This is the way the hind legs of a frog separated from the rest of the body, reason, when you pinch them. It is the lowest form of psychical manifestation."

"But no mental action seems necessary or invariable in its character. In whatever manner the mind has reacted under a given sensation, in that manner it is the more likely to react again; were this, however, an absolute necessity, habits would become wooden and ineradicable, and no room being left for the formulation of new habits, intellectual life would come to a speedy close. Thus, the uncertainty of the mental law is no mere defect of it, but is on the contrary of its essence. The truth is, the mind is not subject to "law," in the same rigid sense that matter is. It only experiences gentle forces which merely render it more likely to act a given way than it otherwise would be. There always remains a certain amount of arbitrary spontaneity in its action, without which it would be dead."

"Let me now try to gather up all these odds and ends of commentary and restate the law of mind, in a unitary way."

"First then, we find that when we regard ideas from a nominalistic, individualistic, sensualistic way, the simplest facts of mind become utterly meaningless. That one idea should resemble another or influence another, or that one state of mind should so much as be thought of in another is, from that standpoint, sheer nonsense."

"Second, by this and other means we are driven to perceive, what is quite evident in itself, that instantaneous feelings flow together in a continuum of feeling, which has in a modified degree the peculiar vivacity of feeling and has gained generality. And in reference to such general ideas, or continua of feeling, the difficulties about resemblance and suggestion and reference to the external, cease to have any force."

"Third, these general ideas are not mere words, nor do they consist in this, that certain concrete facts will every time happen under certain descriptions of conditions; but they are just as much, or rather far more, living realities than the feelings themselves out of which they are concreted. And to say that mental phenomenon are governed by law does not mean merely that they are describable by a general formula; but that there is a living idea, a conscious continuum of feeling which pervades them, and to which they are docile."

"Fourth, this supreme law, which is celestial and living harmony, does not so much as demand that the special ideas shall surrender their peculiar arbitrariness and caprice entirely; for that would be self-destructive. It only requires that they influence and be influenced by one another."

"Fifth, in what measure this unification acts, seems to be regulated only by special rules; or, at least, we cannot in our present knowledge say how far it goes. But it may be said that, judging by appearances, the amount of arbitrariness in the phenomenon of human minds is neither altogether trifling nor very prominent."

"Were the ends of a person already explicit, there would be no room for development, for growth, for life; and consequently there would be no personality. The mere carrying out of predetermined purposes is mechanical. This remark has an application to the philosophy of religion. It is that genuine evolutionary philosophy, that is, one that makes the principle of growth a primordial element of the universe, is so far from being antagonistic to the idea of a personal creator, that it is really inseparable from that idea; while a necessitarian religion is in an altogether false position and is destined to become disintegrated. But a pseudo-evolutionism which enthrones mechanical law above the principle of growth is at once scientifically unsatisfactory, as giving no possible hint of how the universe has come about, and hostile to all hopes of personal relations to God."

"The recognition by one person of another's personality takes place by means to some extent identical to the means by which he is conscious of his own personality. The idea of the second personality, which is as much as to say that second personality itself, enters within the direct consciousness of the first person, and is immediately perceived as his ego, though less strongly. At the same time, the opposition between the two persons is perceived, so that the externality of the second is perceived."

"But the extraordinary insight which some persons are able to gain of others from indications so slight that it is difficult to ascertain what they are, is certainly rendered more comprehensible by the view here taken."

"A difficulty which confronts the synechistic philosophy is this. In considering personality, that philosophy is forced to accept the doctrine of a personal God; but in considering communication, it cannot but admit that if there is a personal God, we must have a direct perception of that person and indeed be in personal communication with him. Now, if that be the case, the question arises how it is possible that the existence of this being should ever have been doubted by anybody. The only answer that I can at present make is that facts that stand before our face and eyes and stare us in the face are far from being, in all cases, the ones most easily discerned. That has been remarked since time immemorial."

"I think that I have succeeded in making it clear that this doctrine gives room for explanations of many facts which without it are absolutely and hopelessly inexplicable; and further that it carries along with it the following doctrines: first, a logical realism of the most pronounced type; second, objective idealism; third, tychism, with its consequent thoroughgoing evolutionism. We also notice that the doctrine presents no hindrences to spiritual influences, such as some philosophies are felt to do."

"A certain maxim of Logic which I have called Pragmatism has recommended itself to me for diverse reasons and on sundry considerations. Having taken it as my guide for most of my thought, I find that as the years of my knowledge of it lengthen, my sense of the importance of it presses upon me more and more. If it is only true, it is certainly a wonderfully efficient instrument. It is not to philosophy only that it is applicable. I have found it of signal service in every branch of science that I have studied. My want of skill in practical affairs does not prevent me from perceiving the advantage of being well imbued with pragmatism in the conduct of life."

"Be it understood, then, that what we have to do, as students of phenomenology, is simply to open our mental eyes and look well at the phenomenon and say what are the characteristics that are never wanting in it, whether that phenomenon be something that outward experience forces upon our attention, or whether it be the wildest of dreams, or whether it be the most abstract and general of the conclusions of science. The faculties which we must endeavor to gather for this work are three. The first and foremost is that rare faculty, the faculty of seeing what stares one in the face, just as it presents itself, unreplaced by any interpretation, unsophisticated by any allowance for this or for that supposed modifying circumstance. This is the faculty of the artist who sees for example the apparent colors of nature as they appear. When the ground is covered by snow on which the sun shines brightly except where shadows fall, if you ask any ordinary man what its color appears to be, he will tell you white, pure white, whiter in the sunlight, a little greyish in the shadow. But that is not what is before his eyes that he is describing; it is his theory of what ought to be seen. The artist will tell him that the shadows are not grey but a dull blue and that the snow in the sunshine is of a rich yellow. That artist's observational power is what is most wanted in the study of phenomenology. The second faculty we must strive to arm ourselves with is a resolute discrimination which fastens itself like a bulldog upon the particular feature that we are studying, follows it wherever it may lurk, and detects it beneath all its disguises. The third faculty we shall need is the generalizing power of the mathematician who produces the abstract formula that comprehends the very essence of the feature under examination purified from all admixture of extraneous and irrelevant accompaniments."

"When anything is present to the mind, what is the very first and simplest character to be noted in it, in every case, no matter how little elevated the object may be? Certainly, it is its presentness."

"The quality of feeling is the true psychical representative of the first category of the immediate as it is in its immediacy, of the present in its direct positive presentness. Qualities of feeling show myriad-fold variety, far beyond what the psychologists admit. This variety however is in them only insofar as they are compared and gathered into collections. But as they are in their presentness, each is sole and unique; and all the others are absolute nothingness to it — or rather much less than nothingness, for not even a recognition as absent things or as fictions is accorded to them. The first category, then, is Quality of Feeling, or whatever is such as it is positively and regardless of aught else."

"The next simplest feature that is common to all that comes before the mind, and consequently, the second category, is the element of Struggle."

"In all the works on pedagogy that ever I read — and they have been many, big, and heavy — I don't remember that any one has advocated a system of teaching by practical jokes, mostly cruel. That, however, describes the method of our great teacher, Experience. She says,"

"Understand me well. My appeal is to observation — observation that each of you must make for himself."

"Thus far, gentlemen, I have been insisting very strenuously upon what the most vulgar common sense has every disposition to assent to and only ingenious philosophers have been able to deceive themselves about. But now I come to a category which only a more refined form of common sense is prepared willingly to allow, the category which of the three is the chief burden of Hegel's song, a category toward which the studies of the new logico-mathematicians, Georg Cantor and the like, are steadily pointing, but to which no modern writer of any stripe, unless it be some obscure student like myself, has ever done anything approaching to justice."

"There never was a sounder logical maxim of scientific procedure than Ockham's razor: Entia non sunt multiplicanda praeter necessitatem. That is to say; before you try a complicated hypothesis, you should make quite sure that no simplification of it will explain the facts equally well. No matter if it takes fifty generations of arduous experimentation to explode the simpler hypothesis, and no matter how incredible it may seem that that simpler hypothesis should suffice, still fifty generations are nothing in the life of science, which has all time before it; and in the long run, say in some thousands of generations, time will be economized by proceeding in an orderly manner, and by making it an invariable rule to try the simpler hypothesis first. Indeed, one can never be sure that the simpler hypothesis is not the true one, after all, until its cause has been fought out to the bitter end. But you will mark the limitation of my approval of Ockham's razor. It is a sound maxim of scientific procedure. If the question be what one ought to believe, the logic of the situation must take other factors into account. Speaking strictly, belief is out of place in pure theoretical science, which has nothing nearer to it than the establishment of doctrines, and only the provisional establishment of them, at that. Compared with living belief it is nothing but a ghost. If the captain of a vessel on a lee shore in a terrific storm finds himself in a critical position in which he must instantly either put his wheel to port acting on one hypothesis, or put his wheel to starboard acting on the contrary hypothesis, and his vessel will infallibly be dashed to pieces if he decides the question wrongly, Ockham's razor is not worth the stout belief of any common seaman. For stout belief may happen to save the ship, while Entia non sunt multiplicanda praeter necessitatem would be only a stupid way of spelling Shipwreck. Now in matters of real practical concern we are all in something like the situation of that sea-captain."

"Philosophy, as I understand the word, is a positive theoretical science, and a science in an early stage of development. As such it has no more to do with belief than any other science. Indeed, I am bound to confess that it is at present in so unsettled a condition, that if the ordinary theorems of molecular physics and of archaeology are but the ghosts of beliefs, then to my mind, the doctrines of the philosophers are little better than the ghosts of ghosts. I know this is an extremely heretical opinion."

"The third category of which I come now to speak is precisely that whose reality is denied by nominalism. For although nominalism is not credited with any extraordinarily lofty appreciation of the powers of the human soul, yet it attributes to it a power of originating a kind of ideas the like of which Omnipotence has failed to create as real objects, and those general conceptions which men will never cease to consider the glory of the human intellect must, according to any consistent nominalism, be entirely wanting in the mind of Deity."

"All nature abounds in proofs of other influences than merely mechanical action, even in the physical world. They crowd in upon us at the rate of several every minute. And my observation of men has led me to this little generalization. Speaking only of men who really think for themselves and not of mere reporters, I have not found that it is the men whose lives are mostly passed within the four walls of a physical laboratory who are most inclined to be satisfied with a purely mechanical metaphysics. On the contrary, the more clearly they understand how physical forces work the more incredible it seems to them that such action should explain what happens out of doors. A larger proportion of materialists and agnostics is to be found among the thinking physiologists and other naturalists, and the largest proportion of all among those who derive their ideas of physical science from reading popular books."

"The word "God," so "capitalised" (as we Americans say), is the definable proper name, signifying Ens necessarium; in my belief Really creator of all three Universes of Experience."

"Some words shall herein be capitalised when used, not as vernacular, but as terms defined. Thus an "idea" is the substance of an actual unitary thought or fancy; but "Idea," nearer Plato's idea of ἰδέα, denotes anything whose Being consists in its mere capacity for getting fully represented, regardless of any person's faculty or impotence to represent it."

"Of the three Universes of Experience familiar to us all, the first comprises all mere Ideas, those airy nothings to which the mind of poet, pure mathematician, or another might give local habitation and a name within that mind. Their very airy-nothingness, the fact that their Being consists in mere capability of getting thought, not in anybody's Actually thinking them, saves their Reality. The second Universe is that of the Brute Actuality of things and facts. I am confident that their Being consists in reactions against Brute forces, notwithstanding objections redoubtable until they are closely and fairly examined. The third Universe comprises everything whose being consists in active power to establish connections between different objects, especially between objects in different Universes. Such is everything which is essentially a Sign — not the mere body of the Sign, which is not essentially such, but, so to speak, the Sign's Soul, which has its Being in its power of serving as intermediary between its Object and a Mind."

"An "Argument" is any process of thought reasonably tending to produce a definite belief. An "Argumentation" is an Argument proceeding upon definitely formulated premisses. If God Really be, and be benign, then, in view of the generally conceded truth that religion, were it but proved, would be a good outweighing all others, we should naturally expect that there would be some Argument for His Reality that should be obvious to all minds, high and low alike, that should earnestly strive to find the truth of the matter; and further, that this Argument should present its conclusion, not as a proposition of metaphysical theology, but in a form directly applicable to the conduct of life, and full of nutrition for man's highest growth. What I shall refer to as the N.A. — the Neglected Argument — seems to me best to fulfil this condition, and I should not wonder if the majority of those whose own reflections have harvested belief in God must bless the radiance of the N.A. for that wealth. Its persuasiveness is no less than extraordinary; while it is not unknown to anybody. Nevertheless, of all those theologians (within my little range of reading) who, with commendable assiduity, scrape together all the sound reasons they can find or concoct to prove the first proposition of theology, few mention this one, and they most briefly. They probably share those current notions of logic which recognise no other Arguments than Argumentations."

"The hypothesis of God is a peculiar one, in that it supposes an infinitely incomprehensible object, although every hypothesis, as such, supposes its object to be truly conceived in the hypothesis. This leaves the hypothesis but one way of understanding itself; namely, as vague yet as true so far as it is definite, and as continually tending to define itself more and more, and without limit. The hypothesis, being thus itself inevitably subject to the law of growth, appears in its vagueness to represent God as so, albeit this is directly contradicted in the hypothesis from its very first phase. But this apparent attribution of growth to God, since it is ineradicable from the hypothesis, cannot, according to the hypothesis, be flatly false. Its implications concerning the Universes will be maintained in the hypothesis, while its implications concerning God will be partly disavowed, and yet held to be less false than their denial would be. Thus the hypothesis will lead to our thinking of features of each Universe as purposed; and this will stand or fall with the hypothesis. Yet a purpose essentially involves growth, and so cannot be attributed to God. Still it will, according to the hypothesis, be less false to speak so than to represent God as purposeless."

"Unless man have a natural bent in accordance with nature's, he has no chance of understanding nature at all."

"The difference between a pessimistic and an optimistic mind is of such controlling importance in regard to every intellectual function, and especially for the conduct of life, that it is out of the question to admit that both are normal, and the great majority of mankind are naturally optimistic."

"The third argument, enclosing and defending the other two, consists in the development of those principles of logic according to which the humble argument is the first stage of a scientific inquiry into the origin of the three Universes, but of an inquiry which produces, not merely scientific belief, which is always provisional, but also a living, practical belief, logically justified in crossing the Rubicon with all the freightage of eternity."

"My original essay, having been written for a popular monthly, assumes, for no better reason than that real inquiry cannot begin until a state of real doubt arises and ends as soon as Belief is attained, that "a settlement of Belief," or, in other words, a state of satisfaction, is all that Truth, or the aim of inquiry, consists in. The reason I gave for this was so flimsy, while the inference was so nearly the gist of Pragmaticism, that I must confess the argument of that essay might with some justice be said to beg the question. The first part of the essay, however, is occupied with showing that, if Truth consists in satisfaction, it cannot be any actual satisfaction, but must be the satisfaction which would ultimately be found if the inquiry were pushed to its ultimate and indefeasible issue. This, I beg to point out, is a very different position from that of Mr Schiller and the pragmatists of to-day. I trust I shall be believed when I say that it is only a desire to avoid being misunderstood in consequence of my relations with pragmatism, and by no means as arrogating any superior immunity from error which I have too good reason to know that I do not enjoy, that leads me to express my personal sentiments about their tenets. Their avowedly undefinable position, if it be not capable of logical characterisation, seems to me to be characterised by an angry hatred of strict logic, and even some disposition to rate any exact thought which interferes with their doctrines as all humbug. At the same time, it seems to me clear that their approximate acceptance of the Pragmaticist principle, and even that very casting aside of difficult distinctions (although I cannot approve of it), has helped them to a mightily clear discernment of some fundamental truths that other philosophers have seen but through a mist, and most of them not at all. Among such truths — all of them old, of course, yet acknowledged by few — I reckon their denial of necessitarianism; their rejection of any "consciousness" different from a visceral or other external sensation; their acknowledgment that there are, in a Pragmatistical sense, Real habits (which Really would produce effects, under circumstances that may not happen to get actualised, and are thus Real generals); and their insistence upon interpreting all hypostatic abstractions in terms of what they would or might (not actually will) come to in the concrete. It seems to me a pity they should allow a philosophy so instinct with life to become infected with seeds of death in such notions as that of the unreality of all ideas of infinity and that of the mutability of truth, and in such confusions of thought as that of active willing (willing to control thought, to doubt, and to weigh reasons) with willing not to exert the will (willing to believe)."

"If we endeavor to form our conceptions upon history and life, we remark three classes of men. The first consists of those for whom the chief thing is the qualities of feelings. These men create art. The second consists of the practical men, who carry on the business of the world. They respect nothing but power, and respect power only so far as it [is] exercized. The third class consists of men to whom nothing seems great but reason. If force interests them, it is not in its exertion, but in that it has a reason and a law. For men of the first class, nature is a picture; for men of the second class, it is an opportunity; for men of the third class, it is a cosmos, so admirable, that to penetrate to its ways seems to them the only thing that makes life worth living."

"Do not block the way of inquiry."

"The idea does not belong to the soul; it is the soul that belongs to the idea."

"Effort supposes resistance."

"The ordinary logic has a great deal to say about genera and species, or in our nineteeth century dialect, about classes. Now a class is a set of objects comprising all that stand to one another in a special relation of similarity. But where ordinary logic talks of classes the logic of relatives talks of systems. A system is a set of objects comprising all that stands to one another in a group of connected relations. Induction according to ordinary logic rises from the contemplation of a sample of a class to that of a whole class; but according to the logic of relatives it rises from the comtemplation of a fragment of a system to the envisagement of the complete system."

"It is ...easy to be certain. One has only to be sufficiently vague."

"Every man is fully satisfied that there is such a thing as truth, or he would not ask any question."

"To say, therefore, that thought cannot happen in an instant, but requires a time, is but another way of saying that every thought must be interpreted in another, or that all thought is in signs."

"Let us not pretend to doubt in philosophy what we do not doubt in our hearts."

"Consider what effects that might conceivably have practical bearings you conceive the objects of your conception to have. Then, your conception of those effects is the whole of your conception of the object."

"All the evolution we know of proceeds from the vague to the definite."

"Mere imagination would indeed be mere trifling; only no imagination is mere."

"Our whole past experience is continually in our consciousness, though most of it sunk to a great depth of dimness. I think of consciousness as a bottomless lake, whose waters seem transparent, yet into which we can clearly see but a little way."

"Peirce, to my knowledge, is original and unique in stressing the problem of studying the rules that limit the class of possible theories. Of course, his concept of abduction, like Lorenz’s biological a priori, has a strongly Kantian flavor, and all derive from the rationalist psychology that concerned itself with the forms, the limits, and the principles that provide “the sinews and connections” for human thought, that underlie “that infinite amount of knowledge of which we are not always conscious,” of which Leibnitz spoke. It is therefore quite natural that we should link these developments to the revival of philosophical grammar, which grew from the same soil as an attempt, quite fruitful and legitimate, to explore one basic facet of human intelligence."

"Pierce wrote as a logician and James as a humanist."

"The principle of interpretation says that "a sign is something by knowing which we know something more" (Peirce). The Peircean idea of semiosis is the idea of an infinite process of interpretation."

"Peirce was concerned to explicate the idea of meaning whereas James was concerned to explicate the meaning of ideas."

"James called Peirce the most original thinker of their generation; Peirce placed himself somewhere near the rank of Leibniz. This much is now certain; he is the most original and versatile of America's philosophers and America's greatest logician."

"Peirce held that the continuity of space, time, ideation, feeling, and perception is an irreducible deliverance of science, and that an adequate conception of the continuous is an extremely important part of all the sciences. This doctrine he called “synechism,” a word deriving from the Greek preposition that means “(together) with.”"

"Peirce was a man of tremendous energy, producing a multitude of ideas, good, bad, and indifferent. He reminds on of a volcano spouting vast masses of rock, of which some, on examination, turn out to be nuggets of pure gold. He holds―and I confess that an examination of scientific inference has made me feel the force of this view―that man is adapted, by his congenital constitution, to the apprehension of natural laws which cannot be proved by experience, although experience is in conformity with them."

"Beyond doubt ... he was one of the most original minds of the later nineteenth century and certainly the greatest American thinker ever."

"One of the greatest philosophers of all time."

"Ultimately, the last word is never ours. Peirce said: the meaning of my life is entrusted to others. [...] Which proves that truth is never something definitive; we are always mistaken. On a journey. It is no coincidence that I speak of the “transit of truth.”"

"Conceptual graphs are system of logic based on the existential graphs of Charles Sanders Peirce and the semantic networks of artificial intelligence. The purpose of the system is to express meaning in a form that is logically precise, humanly readable, and computationally tractable."

"Professor Klein then speaks of "that artistic finish that we admire in Euclid's Elements," and mentions Allman's important historical work. I heartily concur in this estimate of Euclid, and desire to contrast it with the error of Charles S. Peirce, in the Nation, where he speaks of "Euclid's proof (Elements Bk. I., props. 16 and 17)" as "really quite fallacious, because it uses no premises not as true in the case of spherics." Our bright American seems to have forgotten Euclid's Postulate 6 (Axiom 12 in Gregory, Axiom 9 in Heiberg), "Two straight lines cannot enclose a space;" that is, two straights having crossed never recur."

"Recently I have gone back to church regularly with a new focus to understand as best I can what it is that makes Christianity so vital and powerful in the lives of billions of people today, even though almost 2000 years have passed since the death and resurrection of Christ. Although I suspect I will never fully understand, I now think the answer is very simple: it's true. God did create the universe about 13.7 billion years ago, and of necessity has involved Himself with His creation ever since. The purpose of this universe is something that only God knows for sure, but it is increasingly clear to modern science that the universe was exquisitely fine-tuned to enable human life. We are somehow critically involved in His purpose. Our job is to sense that purpose as best we can, love one another, and help Him get that job done."

"[Duesberg] is absolutely correct in saying that no one has proven that AIDS is caused by the AIDS virus. And he is absolutely correct that the virus cultured in the laboratory may not be the cause of AIDS."

"The community as a whole doesn't listen patiently to critics who adopt alternative viewpoints. Although the great lesson of history is that knowledge develops through the conflict of viewpoints. If you simply have a consensus, it generally stultifies. It fails to see the problems of that consensus and it depends on the existence of critics to break up that iceberg and permit knowledge to develop. This is in fact one of the underpinnings of democratic theory. It is one of the reasons why we believe in notions of free speech and it's one of the great forces in terms of intellectual development."

"I would not be surprised if there were another cause of AIDS and even that HIV is not involved."

"I am afraid that those comments go back to the late 80's. At that time I was a skeptic — the argument based on Koch's postulates to try to distinguish between cause and association. … Today I would regard the success of the many antiviral agents which lower the virus titers (to be expected) and also resolve the failure of the immune system (only expected if the virus is the cause of the failure) as a reasonable proof of the causation argument"

"The God of the Bible is also the God of the genome. He can be worshipped in the cathedral or in the laboratory. His creation is majestic, awesome, intricate, and beautiful."

"As someone who's had the privilege of leading the human genome project, I've had the opportunity to study our own DNA instruction book at a level of detail that was never really possible before. It's also now been possible to compare our DNA with that of many other species. The evidence supporting the idea that all living things are descended from a common ancestor is truly overwhelming. I would not necessarily wish that to be so, as a Bible-believing Christian. But it is so. It does not serve faith well to try to deny that."

"There are answers that science isn’t able to provide about the natural world—the questions about why instead of the questions about how. I’m interested in the whys. I find many of those answers in the spiritual realm. That in no way compromises my ability to think rigorously as a scientist."

"Yes, evolution by descent from a common ancestor is clearly true. If there was any lingering doubt about the evidence from the fossil record, the study of DNA provides the strongest possible proof of our relatedness to all other living things."

""We'll get closer to perfect kids from caring families and good education than we'll ever get from genetics." 2005 National DNA Day Online Chatroom Transcript, https://www.genome.gov/DNADay/q.cfm?aid=5419&year=2005"

"Reason alone cannot prove the existence of God. Faith is reason plus revelation, and the revelation part requires one to think with the spirit as well as with the mind. You have to hear the music, not just read the notes on the page."

"I was an atheist, finding no reason to postulate the existence of any truths outside of mathematics, physics and chemistry. But then I went to medical school, and encountered life and death issues at the bedsides of my patients. Challenged by one of those patients, who asked "What do you believe, doctor?", I began searching for answers."

"I would not expect religion to be the right tool for sequencing the human genome and by the same token would not expect science to be the means to approaching the supernatural. But on the really interesting larger questions, such as ‘Why are we here?’ or ‘Why do human beings long for spirituality?,’ I find science unsatisfactory. Many superstitions have come into existence and then faded away. Faith has not, which suggests it has reality."

"... God must also be an incredible physicist ... there is this phenomenal fine-tuning of the universe that makes complexity and, therefore, life possible."

"Some things may have been tried before their time, but if these things don't violate the laws of physics they are likely to prove possible the next time around. Engineering is a series of failures with an occasional success. At least the kind where you are really looking at new technology. You tend to try things. You try things that are extrapolations of what has happened before. A lot of them don't work. Occasionally, you hit one that does. That's the way we make progress. Failures are not something to be avoided. You want to have them happen as quickly as you can so you can make progress rapidly. But, I've known technical people who are very competent but who would avoid doing a critical experiment. They would kind of work around the problem and do the things where the results were relatively straightforward, but they hated to do that experiment that might tell if their whole approach was right or wrong. And these people were relatively nonproductive. Then I've known other people who weren't perhaps as bright as the ones that worked around the problem who jumped right at the heart of the matter. They turn out to be the most productive. So my single piece of advice is don't delay making the critical test. That's the one that will tell you if you are right or wrong and where to go next."

"The complexity for minimum component costs has increased at a rate of roughly a factor of two per year... Certainly over the short term this rate can be expected to continue, if not to increase. Over the longer term, the rate of increase is a bit more uncertain, although there is no reason to believe it will not remain nearly constant for at least 10 years. That means by 1975, the number of components per integrated circuit for minimum cost will be 65,000. I believe that such a large circuit can be built on a single wafer."

"With engineering, I view this year's failure as next year's opportunity to try it again. Failures are not something to be avoided. You want to have them happen as quickly as you can so you can make progress rapidly."

"The technology at the leading edge changes so rapidly that you have to keep current after you get out of school. I think probably the most important thing is having good fundamentals."

"I had no idea this was going to be an accurate prediction, but amazingly enough instead of 10 [years] doubling, we got nine over the 10 years, but still followed pretty well along the curve."

"If the auto industry advanced as rapidly as the semiconductor industry, a Rolls Royce would get half a million miles per gallon, and it would be cheaper to throw it away than to park it."

"God used processes which are not now operating anywhere in the natural universe. This is why we refer to divine creation as special creation. We cannot discover by scientific investigation anything about the creative processes used by God.(Evolution: The Fossils Say No, page 42)"

"Neither evolution nor creation qualifies as a scientific theory."

"Intelligent Design is Creationism."

"If we look at certain proteins, yes, man then -- it can be assumed that man is more closely related to a chimpanzee than other things. But on the other hand, if you look at other certain proteins, you'll find that man is more closely related to a bullfrog than he is a chimpanzee. If you focus your attention on other proteins, you'll find that man is more closely related to a chicken than he is to a chimpanzee." (Gish has repeatedly been challenged to support this claim, but has failed to do so: **Source)"

"Dr. Gish has always been fond of quoting Isaac Asimov as his authority on the Second Law. In our journal, Creation/Evolution, Issue VI, Dr. Asimov responded. He described Gish's treatment of the Second Law as being, and I quote, "on a kindergarten level.""

"Sonny, I'm old enough to have changed your nappies."

"If we do not add something to the knowledge of cosmic rays by our trip to the stratosphere this summer, we had better not go. We had better stay on the ground, be hewers of wood and drawers of water."

"When you fly a balloon you don’t file a flight plan; you go where the wind goes. You feel like part of the air. You almost feel like part of eternity, and you just float along."

"There are many reasons, some of them so deep-seated emotionally as to be very difficult of expression. Possibly the simplest explanation is that we started along this road … and I cannot stop until I have won."

"From China to America to Mecca, forget mandates from Heaven, Jesus, or God. They do not exist. An a-priori mandate, however, does exist from metaphorical Zons here on Earth and across the cosmos."

"Finally, let me explain why this De la Rosa World Summit is the last Neo-Tech summit -- and why that may be the best news. But, first, I want to hail whom I believe to be the most genuinely-happy spirit in today’s anticivilization -- a beautiful person who brings to us her happiness made from the love of life as we travel toward the Civilization of the Universe. Let us emblazon our own spirits by remembering this lovely beam of light -- this enduring beacon of joy, this amazingly-wonderful person -- our free-spirit Summit impresario, Rosa María Wallace. ...What a woman!"

"May we gain the time needed to succeed."

"Business is the highest evolution of consciousness, responsibility, and morality. No other living organism is even remotely able to function on a business level. The essences of business are honesty, effort, responsibility, integration, abstraction, conceptualization, objectivity, long-range planning, discipline, thought, control. Business creates essentially every major human value, ranging from the development of consciousness, language, mathematics, the arts, up to the electronic and biogenic revolutions."

"The major enemy of poker players is their rationalizations for their failures to think....Many poor players evade thinking by letting their minds sink into irrational fogs. Their belief in luck short-circuits their minds by excusing them from their responsibility to think. Belief in luck is a great mystical rationalization for the refusal to think."

"One of the principal objects of theoretical research is to find the point of view from which the subject appears in the greatest simplicity."

"His true monument lies not on the shelves of libraries, but in the thoughts of men, and in the history of more than one science."

"In all these papers we see a love of honest work, an aversion to shams, a caution in the enunciation of conclusions, a distrust of rash generalizations and speculations based on uncertain premises. He was never anxious to add one more guess on doubtful matters in the hope of hitting the truth, or what might pass as such for a time, but was always ready to take infinite pains in the most careful testing of every theory. With these qualities was united a modesty which forbade the pushing of his own claims and desired no reputation except the unsought tribute of competent judges."

"The laws of thermodynamics, as empirically determined, express the approximate and probable behavior of systems of a great number of particles, or, more precisely, they express the laws of mechanics for such systems as they appear to beings who have not the fineness of perception to enable them to appreciate quantities of the order of magnitude of those which relate to single particles, and who cannot repeat their experiments often enough to obtain any but the most probable results."

"We avoid the gravest difficulties when, giving up the attempt to frame hypotheses concerning the constitution of matter, we pursue statistical inquiries as a branch of rational mechanics."

"Mathematics is a language."

"The whole is simpler than its parts."

"Anyone having these desires will make these researches."

"I wish to know systems."

"A mathematician may say anything he pleases, but a physicist must be at least partially sane."

"If I have had any success in mathematical physics, it is, I think, because I have been able to dodge mathematical difficulties."

"Unassuming in manner, genial and kindly in his intercourse with his fellow-men, never showing impatience or irritation, devoid of personal ambition of the baser sort or of the slightest desire to exalt himself, he went far toward realizing the ideal of the unselfish, Christian gentleman. In the minds of those who knew him, the greatness of his intellectual achievements will never overshadow the beauty and dignity of his life."

"In the last generation, this country produced one of the most eminent men of science in the whole world. His name was quite unknown among us while he lived, and it is still unknown. Yet I may say without too great exaggeration that when I heard it mentioned in a professional assembly in the Netherlands two years ago, everybody got down under the table and touched their foreheads to the floor. His name was Josiah Willard Gibbs."

"On the one hand, the student has been informed by some writers that the only certain way lies in the use of the entropy-function and the thermodynamic potentials; on the other hand, he is told with equal authority that the method used by the original investigators has been the consideration of cyclic processes, and that the former method is nothing but a mathematical (perhaps unnecessary) refinement of the results obtained by the latter. These extreme attitudes appear to me to be unfortunate, and more especially when one observes the physical clearness introduced by the use of cyclic processes, but at the same time remembers that most of the results obtained by separate investigators using cyclic processes had, with a great many more, previously been found by J. Willard Gibbs by means of a purely analytical method."

"Let a drop of wine fall into a glass of water; whatever be the law that governs the internal movement of the liquid, we will soon see it tint itself uniformly pink and from that moment on, however we may agitate the vessel, it appears that the wine and water can separate no more. All this, Maxwell and Boltzmann have explained, but the one who saw it in the cleanest way, in a book that is too little read because it is difficult to read, is Gibbs, in his Principles of Statistical Mechanics."

"Willard Gibbs is the type of the imagination at work in the world. His story is that of an opening up which has had its effect on our lives and our thinking; and, it seems to me, it is the emblem of the naked imagination —which is called abstract and impractical, but whose discoveries can be used by anyone who is interested, in whatever "field"— an imagination which for me, more than that of any other figure in American thought, any poet, or political, or religious figure, stands for imagination at its essential points."

"...only one man lived who could understand Gibbs's papers. That was Maxwell, and now he is dead."

"Maxwell, and then Boltzmann, and then... J. Willard Gibbs... expended enormous intellectual effort in devising... , or... . The uses... extend far beyond gases... describing electric and magnetic interactions, chemical reactions, phase transitions... and all other manner of exchanges of matter and energy. The success... has driven the belief among many physicists that it could be applied with similar success to society. ...[E]verything from the flow of funds in the stock market to the flow of traffic on interstate highways ..."

"Many men have had intuitions well ahead of their time; and this is not least true in mathematical physics. Gibbs' introduction of probability into physics occurred well before there was an adequate theory of the sort of probability he needed. But for all these gaps it is, I am convinced, Gibbs rather than Einstein or Heisenberg or Planck to whom we must attribute the first great revolution of twentieth century physics."

"[Gibbs' 1878] paper stands today as one of the most profound contributions to the world of human thought and […] places him with the greatest of the world's geniuses."

"... a comparison of the American regard for inventive skill as opposed to skill in pure science. Our greatest inventive genius, Thomas A. Edison, was all but canonized by the American public, and a legend has been built around him. One cannot, I suppose, expect that achievements in pure science would receive the same public applause that came to inventions as spectacular and as directly influential on ordinary life as Edison’s. But one might have expected that our greatest genius in pure science, Josiah Willard Gibbs, who laid the theoretical foundations for modern physical chemistry, would have been a figure of some comparable acclaim among the educated public. Yet Gibbs, whose work was celebrated in Europe, lived out his life in public and even professional obscurity at Yale, where he taught for thirty-two years. Yale, which led American universities in its scientific achievements during the nineteenth century, was unable in those thirty-two years to provide him with more than a half dozen or so graduate students who could understand his work, and never took the trouble to award him an honorary degree."

"... the magnificent structure of Gibbsian statistical mechanics [cannot] be viewed as founded upon ideal classical gases, Boltzmannian kinetic theory, and the virial and cluster expansions for dilute fluids! True, this last route was still frequently retravelled in textbooks more than 50 years after Gibbs’ major works were published; but it deeply misrepresents the power and range of statistical mechanics... asking ‘‘What does statistical mechanics convey to a physicist?’’ and replying: ‘‘It means that one can compute the second-virial coefficient to correct the ideal gas laws!’’ Of course, historically, that is not a totally irrelevant remark; but it is extremely misleading and, in effect, insults one of America’s greatest theoretical physicists, Josiah Willard Gibbs."

"I suppose that I should say a few words with respect to the possibility for future production and identification of additional transuranium elements, especially in view of the possibility of their production by heavy-ion bombardment of transuranium elements. As an aid to such a program the radioactive properties can be estimated, as I have already indicated, on the assumption of a smooth nuclear energy surface and the systematics of radioactivity. Again, I must emphasize that such considerations are negated in the event that a stable subshell of 148 neutrons should be found to exist, and this must be regarded as a definite possibility. It is interesting to note that our considerations on the systematics of spontaneous fission28 indicate that this method of decay will not compete seriously with radioactive decay until the region just beyond element 100. … These considerations illustrate clearly that one of the problems is that of conceiving means for producing nuclides of sufficiently high mass numbers with half-lives long enough for chemical identification. Thus, the serious problem is again the paucity of starting materials."

"There is a beauty in discovery. There is mathematics in music, a kinship of science and poetry in the description of nature, and exquisite form in a molecule. Attempts to place different disciplines in different camps are revealed as artificial in the face of the unity of knowledge. All literate men are sustained by the philosopher, the historian, the political analyst, the economist, the scientist, the poet, the artisan and the musician."

"To say that Seaborg had a high-profile career is an understatement. He is in the Guiness Book of World Records for having the longest entry in "Who's Who in America." … In 1944, Seaborg formulated the 'actinide concept' of heavy element electronic structure which predicted that the actinides – including the first eleven transuranium elements – would form a transition series analogous to the rare earth series of lanthanide elements. Called one of the most significant changes in the periodic table since Mendeleev's 19th century design, the actinide concept showed how the transuranium elements fit into the periodic table."

"The body of information assembled in Dr. Seaborg's laboratory has made it possible to predict the radioactive characteristics of many isotopes of elements still to be found. Under Dr. Seaborg's leadership, also, whole new bodies of methodology and instrumentation have been developed and have become a cornerstone of modern nuclear chemistry."

"Glenn Seaborg had a tremendous influence on me — both before and after I met him. Of course, as a nuclear chemist, I knew of his leadership in the legendary discovery of plutonium in 1941, the development of the actinide concept, his receipt of the Nobel Prize in 1951, and the discovery of 8 more transplutonium elements by 1958. It was not until his tenure as chairman of the AEC (1961-71) that I actually began to learn first hand about the "real" person behind these awesome accomplishments. … The breadth of his interests, his skill in communicating with both scientists and the general public and press, and his energy in doing all this even while he was AEC chairman still boggles my mind! … I learned so many things from him just by observing how he ran the weekly brown bag lunches with his graduate students and later mine — listening with great interest as they described their research progress. He asked insightful and penetrating questions, but not in a threatening manner, made suggestions, and frequently went to visit the labs late in the day to see what was going on. He also hosted many undergraduate research students. He was devoted to education and student training and would prepare as carefully for lectures to freshman chemistry classes as for presentations to prestigious assemblages of scientists. Glenn was very concerned with history and had kept a diary or journal since he was eight years old. After his return to Berkeley from Washington in 1971, he continued the tremendous undertaking of putting them into book form, which occupied him and several helpers for many years. His journals also formed the basis for books on his years as chancellor at Berkeley, as chairman of the AEC, and many other topics. On the rare occasions that he did not remember something that one of us might ask about he would look it up in his journals. He had a fabulous memory and was able to synthesize and apply and keep track of what he knew so it could be applied to the situation at hand. One might almost say in the parlance of our time that he was a "parallel processor"! … In spite of his legendary accomplishments, Glenn Seaborg always had time for family members, colleagues, students, and even non-scientists who wanted to visit with him. We have lost a treasured advisor, colleague, mentor, resource, and friend. But he will live on through his prolific writings and in the cherished memories of the hosts of students, scientists, colleagues, and lay people that he influenced."

"Dr. Seaborg was a true giant of the 20th Century, a legend in the annals of scientific discovery. His daily commitment to matters of the laboratory, even in retirement as associate director-at-large and as an active researcher, was an inspiration to us all. … We who have been touched by his wisdom, his energy, and his tireless devotion to our profession will miss him."

"...the more accurate the calculations became, the more the concepts tended to vanish into thin air."

"The nature of the chemical bond is the problem at the heart of all chemistry."

"Scientists need to exchange ideas in an informal place."

"In science, conjecture drives both experiment and theory for it is only by forming conjectures (hypotheses) that we can make the direction of our experiments and theories informed. If such and such is true, then I should be able to do this experiment and look for this particular result or I should be able to find this theoretical formulation. Conversely, experiment and theory drive conjecture. One makes a startling observation or has a sudden insight and begins to speculate on its significance and implications and to draw possible conclusions (conjecture)."

"… science is the most revolutionary force in the world."

"The chief requisite for the making of a good chicken pie is chicken; no amount of culinary legerdemain can make up for the lack of chicken. In the same way, the chief requisite for the history of science is intimate scientific knowledge; no amount of philosophic legerdemain can make up for its absence."

"Arabic science was the fruit of Semitic genius fertilized by the Iranian genius."

"The scientific books written in Arabic during the Middle Ages were, for a few centuries, the main vehicle of the living science."

"As I grew older my lectures became simpler; I tried to say fewer things and to say them better, with more humanity. This book continues in a different way the same evolution, but it is not yet as simple as I would have liked to have made it."

"The ability of nonintelligent people to understand the most complicated mechanisms and to use them has always been to me a cause of astonishment: their inability to understand simple questions is even more astonishing. The general acceptance of simple ideas is difficult and rare, and yet it is only when simple, fundamental, ideas have been accepted that further progress becomes possible on a higher level."

"Erudition without pedantry is as a rare as wisdom itself."

"It is childish to assume that science began in Greece; the Greek "miracle" was prepared by millenia of work in Egypt, Mesopotamia and possibly in other regions. Greek science was less an invention than a revival."

"Hellenic science is a victory of rationalism, which appears greater, not smaller, when one is made to realize that it had been won in spite of the irrational beliefs of the Greek people; all in all, it was a triumph of reason in the face of unreason. Some knowledge of Greek superstitions is needed not only for a proper appreciation of that triumph but also for the justification of occasional failures, such as the many Platonic aberrations."

"Scientific achievements seem evanescent, because the very progress of science causes their supersedure; yet some of them are of so fundamental a nature that they are immortal in a deeper way."

"From the humanistic point of view every human achievement is unforgettable and immortal in its essence, even if it is replaced by a "better" one."

"Greek culture is pleasant to contemplate because of its great simplicity and naturalness, and because of the absence of gadgets, each of which is sooner or later a cause of servitude."

"The rationalism of the creative minds was tempered by abundant fantasies, and the supreme beauty of the monuments was probably spoiled by the circumambient vanities and ugliness; in a few cases the Greeks came as close to perfection as it was possible to do, yet they were human and imperfect."

"Our own culture, of Greek and Hebraic origin, is the one that interests us the most... We do not say that it is the best culture, but simply that it is ours. To claim that it of necessity superior would be wrong and evil. That attitude is the main source of international trouble in the world. ...Each nation prefers its own usages."

"My main interest... is the love of truth, whether pleasant or not. Truth is self-sufficient, and there is nothing to which it can be subordinated without loss. When truth is made subservient to anything else, however great (say religion), it becomes impure and sordid."

"Wisdom is not mathematical, nor astronomical, nor zoological; when it talks too much of any one thing it ceases to be itself. There are wise physicists, but wisdom is not physical; there are wise physicians, but wisdom is not medical."

"The historical order is very interesting, but accidental and capricious; if we would to understand the growth of knowledge, we cannot be satisfied with accidents, we must explain how knowledge was gradually built up."

"Some men are abstract-minded, and they naturally think first of unity and God, of wholeness, of infinity and other such concepts, while the minds of other men are concrete and they cogitate about health and disease, profit and loss. They invent gadgets and remedies; they are less interested in knowing anything than in applying whatever knowledge... to practical problems... The first are called dreamers; the second kind are recognized as practical and useful. History has often proved the shortsightedness of the practical men and vindicated the "lazy" dreamers; it has also proved that the dreamers are often mistaken."

"There are two kinds of people in the world, whom we might dub the jobholders and the enthusiasts. ...The majority of the kings and emperors were jobholders and so were many of the popes. ...Most of the creators in the field of art and religion, and many of them in the field of science, were enthusiasts. Now economic conditions may deeply affect the jobs and the jobholders, but they make little impression on the enthusiasts. ...the jobholders ...keep things going with enough continuity and smoothness; they are the builders of usages and customs, the defenders of morality and justice. ...the enthusiasts ...are the main instruments of change and progress; they are the real creators and troublemakers. The enthusiasts are the salt of the earth, but man cannot live by salt alone."

"The history of science should not be an instrument to defend any kind of social or philosophic theory; it should be used only for its own purpose, to illustrate impartially the working of reason against unreason, the gradual unfolding of truth, in all its forms, whether pleasant or unpleasant, useful or useless, welcome or unwelcome."

"We can imagine that the Academy, which could be attended only by men of leisure, was a cradle of discontent. The author of the Laws was a disgruntled old man, full of political rancor, fearing and hating the crowd and above all their demagogues; his prejudices had crystallized and he had become an old doctrinaire, unable to see anything but the reflections of his own personality and to hear anything but the echoes of his own thoughts. The worst of it was that he, a noble Athenian, admired the very Spartans who had defeated and humiliated his fatherland. Plato was witnessing a social revolution (even as we are) and he could not bear it at all. His main concern was: how could one stop it."

"The main task of mankind was accomplished by Muslims. The greatest philosopher, al-Farabi, was a Muslim; the greatest mathematicians, Abu Kamil and Ibrahim ibn Sinan, Were Muslims; the greatest geographer and encyclopaedist, al-Mas'udi, was a Muslim; the greatest historian, aI-Tabari, was still a Muslim."

"The Hellenistic world was international to a degree, polyglot and inspired by many religious faiths. ...the Greek ideals were pagan and the Hellenistic age witnessed their death struggle against Asiatic and Egyptian mysteries, on the one side, and against Judaism, on the other."

"The intensity of a national culture should be represented by... the general education level and... the exceptional merit of a small elite of pioneers."

"In ancient times there was no public education, except that of the forum, the theater, and the street, and the general degree of illiteracy was very high. ...the early men of science were left very much to themselves and such a phrase as "the scientific culture of Alexandria in the third century B.C." does not cover any reality. In a sense, this is still true today; the real pioneers are so far ahead of the crowd (even a very literate crowd) that they remain almost alone..."

"The whole past and the whole world are alive in my heart, and I shall do my part to communicate their presence to my readers."

"A deed happens in a definite place at a definite time, but if it be sufficiently great and pregnant, its virtue radiates everywhere in time and space."

"If we are generous enough, we can stretch our souls everywhere and everywhen else. If we succeed in doing so, we shall discover that our present embraces the past and the future and that the whole world is our province."

"All men are our brothers. As far as the discovery of the truth is concerned, they are all working for the same purpose; they may be separated by the accidents of space and time, and by the exigencies of race, religion, nationality, and other groupings; from the point of view of eternity they are working together."

"Men of science have made abundant mistakes of every kind; their knowledge has improved only because of their gradual abandonment of ancient errors, poor approximations, and premature conclusions."

"Superstitions... are nothing but persistent errors, foolish beliefs, and irrational fears. Superstitions are infinite in number and scope... It would not do to ignore them altogether, only if we should never forget the weakness and fragility of our minds. The consciousness that superstitions are rife in our own society is a healthy shock to our self-conceit and a warning. ...it lets us judge ancient superstitions with more indulgence and with a sense of humor. We could not overlook them without falsifying the general picture nor judge them too severely without hypocrisy."

"I am obliged to deal with hundreds of men and to make them live without killing the reader."

"Ancient portraits are symbolic images without any immediate relation to the individuals represented; they are not portraits as we understand them. ...It is remarkable that philologists who are capable of carrying accuracy to the extremes in the case of words are as credulous as babies when it comes to "images," and yet an image is so full of information that ten thousands words would not add up to it."

"The whole iconography of ancient science is simply the fruit of wishful thinking."

"Some forty years of experience in my field as a scholar and as a teacher have given me great confidence mixed with greater humility."

"My gratitude to them [my first teachers] grows as I myself grow older."

"Every discovery takes place in more than a scientific context."

"One of the most striking characteristics of this new modification of oxygen is its peculiar odor, and hence Schönbein calls it ozone, from a Greek verb signifying to smell. It frequently happens that a great discovery supplies the wanting links between a number of obscure facts, and thus adds quite as much to our knowledge by its indirect bearings as by the positive additions it makes to the general stock. So it has been with the discovery of ozone. Every one who has used an electrical machine must have noticed the peculiar smell which follows the electrical discharge. This was formerly supposed to be the odor of the electrical fluid itself; but as soon as ozone was discovered, the odor was recognized at once as belonging to this new agent, and it was soon ascertained that electricity is one of the most efficient means of modifying the oxygen of the air."

"This fact, that all charges are integral multiples of a fundamental unit, is still one of the unexplained puzzles of fundamental physics. It does not in any way contradict electromagnetic theory, but it is not predicted by it, and until we have a more fundamental theory that explains it, we shall not feel that we really understand electromagnetic phenomena thoroughly. Presumably its explanation will not come until we understand quantum theory more thoroughly than we do at present."

"In general, the rate of evaporation (m) of a substance in a high vacuum is related to the pressure (p) of the saturated vapor by the equation m=\sqrt{\frac{M}{2\pi RT}}p. Red phosphorus and some other substances probably form exceptions to this rule."

"To me, [it's] extremely interesting that men, perfectly honest, enthusiastic over their work, can so completely fool themselves."

"Science, almost from its beginnings, has been truly international in character. National prejudices disappear completely in the scientist’s search for truth. Medicine also disregards national boundaries. And literature frequently rises to heights that make it international. The scientist is motivated primarily by curiosity and a desire for truth. His attitude is objective rather than subjective. In his work he finds great satisfaction in discovering new facts or new relationships between known facts, but even greater pleasure is derived from seeing his results incorporated into the body of scientific knowledge and from seeing them willingly used by others in the further development of science."

"History proves abundantly that pure science, undertaken without regard to applications to human needs, is usually ultimately of direct benefit to mankind. Within recent years it has become possible for purely scientific work of this character to be carried out with the support of industries, which are, of course, primarily interested in the commercial applications. The scientist who works in this way is frequently especially fortunate in that he not only derives the satisfactions which are characteristic of scientific work in general, but is able to see that many of his results are almost immediately put into a form which directly benefits mankind. Happy indeed is the scientist who not only has the pleasures which I have enumerated, but who also wins the recognition of fellow scientists and of the mankind which ultimately benefits from his endeavors. To my mind, the most important aspect of the Nobel Awards is that they bring home to the masses of the peoples of all nations, a realization of their common interests. They carry to those who have no direct contact with science the international spirit."

"A couple of months in the laboratory can frequently save a couple of hours in the library."

", to Frank Westheimer on presenting an idea: (Harvard Gazette)"

"This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work."

"In the current debate about immigration, it is worth noting that this award is yet another example of the numerous contributions that immigrants make to British society."

"Indeed, many of the founding members of the Laboratory of Molecular Biology were immigrants themselves, and they helped to revolutionise modern biology.""

"I think it is the ability to tackle difficult problems in a sort of stable and supportive environment. I think that is the real key to it."

"I was quite insistent. We have quite a few pranksters in the lab and I thought this was one of them. I even congratulated the man, ironically, on his Swedish accent."

"I knew the ribosome was going to be the focus of Nobel prizes. It stands at the crossroads of biology, between the gene and what comes out of the gene. But I had convinced myself I was not going to be a winner."

"I then got a PhD in physics [from Ohio University] though it was hatt hatt and hatt not a very good one."

"I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it."

"It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years. Or your approach may be fatally flawed and doomed to fail. Or you could get scooped just as you are finalising your work. It is very stressful."

"If I had complained about the prize before I got mine, they may have thought I was anticipating sour grapes. But I complained on the grounds that too many important scientists get missed out for Nobels. Science today is a highly collaborative exercise and to convert it into a contest, as the Nobel does, is a bad way to look at science. On the other hand, I am grateful to the committee for my award. It put the study of ribosome – the cellular machine that turns the blueprint of life into life itself – on front pages round the world."

"You would have to ask a physicist really but I think understanding fundamental problems in physics is very important because they are part of our culture. You just never know what is going to come from it. If you had told Isaac Newton about spaceships and satellites that arise from his laws of gravity, it would have been science fiction to him."

"Find out what really fascinates you and follow that. Almost anything in nature, if you follow it, you will find a scientific problem. That is a better way to do it than following fads, because what is fashionable today may have been solved or fallen out of fashion once you have become a working scientist."

"Scientists are trained to be rational and we are not trained to interact with people and develop social skills. Politics is about being able to convince people. Scientists could do with learning how to do that."

"Scientists work by a combination of intuition and insight in trying to understand a question."

"No. Geeks make huge advances in society. Newton was the ultimate geek. It should be a compliment."

"People go into science out of curiosity, not to win awards. But scientists are human and have ambitions. Even the best scientists are often insecure and feel the need for recognition."

"A life of science struck me as being both interesting and international in character."

"Many in my family were ambivalent about it, but my mother encouraged me to put aside my fears. Vera (my wife) and I finally decided to leave Utah, where we were very happy, take a 40 per cent salary cut and move to the Laboratory of Molecular Biology at Cambridge."

"This reconnection...has given me great satisfaction. I realise I have inadvertently become a source of inspiration and hope for people in India simply by the fact that I grew up there, went to my local university, but could go on to do well internationally. The Nobel, he says, is not just an affirmation of his past work; it’s an encouragement to keep working on interesting problems."

"Last year, the lecture was held in [an auditorium] with a capacity for just 300 people, and half the seats were empty. “What has changed? I am still the same person doing the same science. Why are people so impressed when some academy in Sweden gives an award?"

"Dr. Ramakrishnan addressing an audience of 3,000 at the university’s Centenary Auditorium."

"That is the wrong question to ask…You can’t go into science thinking of a Nobel Prize. You can only go into science because you’re interested in it."

"The ribosome does amazing chemistry, but I’m not a chemist…I’ve just learnt enough to work on my problem."

"It’s not about where you were born, or where you come from that makes you a good scientist. What you need are good teachers, co-students, facilities, [he said]. I honestly don’t think my roots have much to do with it. I’m sure this won’t make me popular, but this is what I think."

"My own lab has two Chinese, a Malaysian, a Canadian, an American, a German, it has had all sorts of people. And it’s actually fun because people from different countries come together, they have cultural exchanges, they learn more about each others’ countries and way of life. Science is a great international mixer, so the idea that it is a sort of cricket match where our team won — that simply is a wrong way of looking at scientific discovery."

"It’s an absolutely good thing. I can think of one even better thing for young people, especially in India. It shows them you can study in India, get your basic education in India and you can (then) do whatever you want after that. That’s a very important message."

"Indians tend to be a little insecure and they should stop being insecure — I have visited India many times and I can tell you questions I get after my talks are as perceptive as anywhere else in the world, including places like Harvard or MIT. It’s perfectly fine to take pride that someone from their region has used their background and succeeded. That gives them a positive message that they can do anything that they want."

"Now many excellent scientists in India are doing really first rate work and it should not matter when the next Indian Nobel Prize is because they are doing very good work — that is what matters and the more you have this infrastructure, with good scientists within India, eventually someone will get a Nobel Prize for work done within India."

"There are already people who are world class in India, for example C.N.R. Rao (who has worked mainly in solid-state and structural chemistry). He is an example of how you can do first rate international work within India. So I would say to Indians — you have it within you to do this (in India)."

"Fundamental information about the workings of the cellular machinery at the atomic level and is already being exploited by pharmaceutical companies to make new, more effective antibiotics"

"It is fairly clear that American with recent foreign roots are overrepresented in any classification of Americans who have brought honour and recognition to the United States"

"Part of the charm of synthetic organic chemistry derives from the vastness of the intellectual landscape along several dimensions. First, there is the almost infinite variety and number of possible target structures that lurk in the darkness waiting to be made. Then, there is the vast body of organic reactions that serve to transform one substance into another, now so large in number as to be beyond credibility to a non-chemist. There is the staggering range of reagents, reaction conditions, catalysts, elements, and techniques that must be mobilized in order to tame these reactions for synthetic purposes. Finally, it seems that new information is being added to that landscape at a rate that exceeds the ability of a normal person to keep up with it. In such a troubled setting any author, or group of authors, must be regarded as heroic if through their efforts, the task of the synthetic chemist is eased."

"We live in a troubled, but wonderful time. It is our good fortune to witness and benefit from scientific advances that would have been literally unimaginable to our grandparents. However, there are dark clouds on the horizon. The rate of growth of scientific knowledge has been so great as to outstrip the ability of our society to assimilate it, the capacity of the educational system to teach it properly and the wisdom of government adequately to sustain and apply it. There is growing indifference to science among the young. Even medical science, which touches the lives of us all, is generally left to the practitioners. Whatever the reason for this disparity between the importance of science and the lack of general public understanding, it is important to address it."

"My work is a complex product of a personality continuous with all of nature, and one making progressively better-integrated efforts to structure experience on all levels.... My art is the result of a deeply personal, infinitely complex, and still essentially mysterious, exploration of experience. No words will ever touch it."

"A. No matter what you do, you're always hearing something."

"The misunderstandings have seemed to come from comparing fluxus with movements or groups whose individuals ‘have had some principle in common, or an agreed-upon program. In fluxus there has never been any attempt to agree on aims or methods; individuals with something unnameable in common have simply naturally coalesced to publish and perform their work. Perhaps this common something is a feeling that the bounds of art are much wider than they have conventionally seemed, or that art and certain long-established bounds are no longer very useful. At any rate, individuals in europe, the us, and japan have discovered each other’s work and found it nourishing (or something) and have grown objects and events which are original, and often uncategorizable, in a strange new way."

"fluxus is the “event” according to george brecht:"

"Te reaction types used for functional group exchanges are collected into seven traditional categories [Acid-base reactions, Substitution reactions, Elimination reactions, Addition reactions, Nucleophilic acyl addition, Oxidation reactions, Reduction reactions]."

"Biochemistry asks how the remarkable properties of living organisms arise from the thousands of different biomolecules."

"Organisms possess extraordinary attributes, properties that distinguish them from other collections of matter. What are these distinguishing features of living organisms?"

"Despite these common properties, and the fundamental unity of life they reveal, it is difficult to make generalizations about living organisms."

"The unity and diversity of organisms become apparent even at the cellular level."

"Cells of all kinds share certain structural features."

"The upper limit of cell size is probably set by the rate of diffusion of solute molecules in aqueous systems."

"All living organisms fall into one of three large groups (domains) [Bacteria, Archeara, Eukarya] that define three branches of evolution from a common progenitor."

"The distinguishing characteristics of eukary­otes are the nucleus and a variety of membrane-enclosed organelles with specific functions."

"The current understanding that all organisms share a common evolutionary origin is based in part on this observed universality of chemical intermediates and transformations, often termed "biochemical unity.""

"The chemistry of living organisms is organized around carbon, which accounts for more than half the dry weight of cells."

"We can consider cellular energy conversions—like all other energy conversions—in the context of the laws of thermodynamics."

"Virtually every chemical reaction in a cell occurs at a significant rate only because of the presence of enzymes."

"Perhaps the most remarkable property of living cells and organisms is their ability to reproduce themselves for countless generations with nearly perfect fidelity. This continuity of inherited traits implies constancy, over millions of years, in the structure of the molecules that contain the genetic information."

"Among the seminal discoveries in biology in the twentieth century were the chemical nature and the three-dimensional structure of the genetic material, deoxyribonucleic acid, DNA."

"The remarkable similarity of metabolic pathways and gene sequences across the phyla argues strongly that all modern organisms are derived from a common evolutionary progenitor by a series of small changes (mutations), each of which conferred a selective advantage to some organism in some ecological niche."

"The first living organisms on Earth doubtless arose in an aqueous environment, and the course of evolution has been shaped by the proper­ ties of the aqueous medium in which life began."

"As a result, there is an electrostatic attraction between the oxygen atom of one water molecule and the hydrogen of another (Fig. 2-lb), called a hydrogen bond."

"Water is a polar solvent. It readily dissolves most bio­ molecules, which are generally charged or polar com­ pounds (Table 2-2); compounds that dissolve easily in water are hydrophilic (Greek, "water-loving"). In contrast, nonpolar solvents such as chloroform and benzene are poor solvents for polar biomolecules but easily dis­ solve those that are hydrophobic-nonpolar molecules such as lipids and waxes."

"In thermodynamic terms, formation of the solution occurs with a fa vorable free-energy change: ΔG = ΔH - TΔS, where ΔH has a small positive value and TΔS a large positive value; thus ΔG is negative."

"Upon encountering a new topic, try this: imagine that you are the first person ever to see the laboratory results on which it is based. Imagine that you must construct the new concepts and explanations to interpret these results, and that you will present and defend your conclusions before the scientific community. Be suspicious. Cross-check everything. Demand independent confirmations. Always remain, with Boyle, the “skeptical chemist.”"

"Chemical reasoning, as used both in applications and in basic research, resembles a detective story in which tangible clues lead to a mental picture of events never directly witnessed by the detective."

"The science of chemistry rests on two well-established principles: the conservation of matter and the conservation of energy."

"Chemists think in the highly visual nanoscopic world of atoms and molecules, but they work in the tangible world of macroscopic laboratory apparatus. These two approaches to the chemical sciences cannot be divorced."

"Investigating chemical reactions can be greatly complicated and often obscured by the presence of extraneous materials. So, the first step, therefore, is to learn how to analyze and classify materials to ensure that you are working with pure substances before initiating any reactions."

"The definite mass ratios involved in reactions suggested a convenient method for counting the number of atoms of each element participating in the reaction. These results, summarized as the laws of chemical combination,provided overwhelming, if indirect, evidence for the existence of atoms and molecules."

"Knowledge of the components of the atom and of the forces that hold them together stimulated entirely new fields of basic science and technology that continue to the present."

"Laboratory or industrial chemical reactions are carried out with quantities that range from milligrams to tons, so we must be able to relate the relative atomic mass scale to the macroscopic scales used in practice. The link between the two scales is provided by Avogadro’s number (NA)."

"The conservation of matter in a chemical change is represented in a balanced chemical equation for that process. The study of the relationships between the numbers of reactant and product mole­cules is called stoichiometry. Stoichiometry is fundamental to all as­pects of chemistry."

"We point out that not every reactant is completely consumed in a chemical reaction, and that the limiting reactant determines the maximum theoretical yield; the percentage yield may be somewhat less."

"The shapes of molecules influence their behavior and function, especially the ease with which they can fit into various guest-host configurations important in biology and biochemistry."

"The central idea of quantum theory is that energy, like matter, is not continuous but it exists only in discrete packets. Discreteness of matter and charge on the microscopic scale seems entirely reasonable and familiar to us, based on the modern picture of atomic structure. But, the idea that energy also exists only in discrete chunks is contrary to our experience of the macroscopic world. The motions of a soccer ball rolling up and down the sides of a gully involve arbitrary amounts of kinetic and potential energy; nothing in ordinary human experience suggests that the energy of a system should change abruptly by “jumps.” Understanding quantum mechanics requires that we develop a new kind of physical intuition, based on the results of experiments that are impossible to understand using classical mechanics. These results are completely divorced from ordinary human experience in the macroscopic world around us, and our physical intuition from the macroscopic world cannot be transferred to the quantum domain. We must resist the urge to interpret these quantum results in terms of ordinary experience."

"Quantum mechanics explains the physical stability of the atom by predicting its allowed discrete energy levels and defining the wave functions (also called atomic orbitals) associated with each energy level. The orbitals determine the probability density for finding the electrons at particular locations in the atom when the electrons are in a specific quantum state."

"After all, what's the use of having developed a science well enough to make predictions, if in the end all we're willing to do is stand around and wait for them to come true."

"Boyle entertains the hypothesis of a universal matter, the concept of atoms of different shapes and sizes, and the possibility of existence of substances that might properly be called elements... The atomic theory as originally conceived by Democritus and Epicurus, developed by Lucretius, and resurrected by Gassendi from about 1647 on, was doubtless the source from which Boyle derived his ideas, ...as he cites both Epicurus and Gassendi. Boyle, however... avoids any dogmatic assertion of these hypotheses. It is plain, however, that these atoms or "corpuscles" as he calls them are a constant element of his thought."

"The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both."

"Be a physical chemist, an analytical chemist, an organic chemist, if you will; but above all, be a chemist."

"...as I grew up, we spent a lot of time learning things about the world that most youngsters in cities don’t learn these days."

"I would get up and explain how things really work. That was my job."

"I don’t have any pride, I’m sorry to say. I have zero pride in any award. All I feel is obligation, obligation, and obligation."

"Many cissexual people seem to have a hard time accepting the idea that they too have a subconscious sex — a deep-rooted understanding of what sex their bodies should be. I suppose that when a person feels right in the sex they were born into, they are never forced to locate or question their subconscious sex, to differentiate it from their physical sex. In other words, their subconscious sex exists, but it is hidden from their view. They have a blind spot. (5 - Blind Spots: On Subconscious Sex and Gender Entitlement)"

"There are numerous forms of marginalization that exist in our society: , classism, sexism, , heterosexism, and so on. If you happen to be on the wrong side of any of these hierarchies, you will face many inequities and injustices. ... Some people are single-issue activists that are only concerned about a single form of marginalization, usually one that impacts them personally. Single-issue perspectives create a distorted view of the world, and lead activists to propose solutions that will help some people while hurting others and leaving countless more behind. ... In contrast, others of us take a more intersectional approach, recognizing that all forms of marginalization intersect with and exacerbate one another, and that we must challenge all of them simultaneously."

"People usually gravitate toward single-issue activism because they are unconcerned about forms of marginalization that do not personally impact them."

"The “principal contradiction” refers to the idea that there is some original or primary form of oppression that gives rise to all the others. ... Of course, there is really only one purpose for making such a claim: to persuade others to join you in your single-issue activist campaign, under the pretense that once your pet oppression is eliminated, all other forms of marginalization will subsequently fall by the wayside too. But the thing is, there is simply no evidence for a principal contradiction. ... There is no primary contradiction, just lots of different hierarchies that people may or may not endorse."

"Here is how I describe the concept of privilege to skeptics: Do you believe that marginalized/minority groups face discrimination and are as a result? If the answer is yes, then another equally valid way of describing the same situation is to say that dominant/majority groups are relatively advantaged in comparison. “Privilege” simply refers to those advantages. One of the reasons why activists frame such matters in terms of privilege is to illustrate how *all of us* are impacted by unjust hierarchies and systems, even if it is not always apparent to us."

"Once a person acknowledges that they possess some form of privilege, they are more likely to accept the reality that they are not in any way objective about the form of marginalization in question"

"I mentioned at the outset that I dislike the term "identity politics." This is because the phrase seems to suggest that our identities (rather than the marginalization we face) is the most salient feature of our activism. Indeed, this is probably why those who oppose IP-umbrella activism seem so fond of calling it “identity politics” in the first place. [...] In contrast, within IP circles, the term is often reserved for a specific brand of single-issue activism that completely precludes perspectives from those who do not share the identity in question."

"Accusations that IP is inherently “narcissistic” and “divisive” have become quite prevalent among EC-centric leftists lately. [...] In addition to disregarding all forms of non-EC marginalization, accusations that IP activism is inherently “narcissistic” or "divisive" severely confuse cause and effect. After all, I’m not the one who is “obsessed” with my identity. [...] It’s the people who harbor anti-trans attitudes who are obsessed with my identity, not the other way around! While I would absolutely love to live in a world where my trans identity was not especially notable or worth calling attention to, these people insist on making an issue out of it. Furthermore, by making a distinction between transgender people (who they single out for discrimination) and non-transgender people (whose identities and experiences they respect), it is they (not us) who are the ones being divisive. Once we acknowledge this causality, it becomes clear that IP is not an expression of navel-gazing or narcissism, but rather a form of organized resistance against those who are actively trying to delegitimize and disenfranchise us."

"I would love to live in a world where the word “transgender” serves the same simple purpose — a mere sharing of information about my life experiences — but unfortunately, it doesn’t. On top of being a descriptor, the word "transgender" is also politically loaded. But that is not my, nor other trans people’s, fault. As discussed in the last section, there’s a long history of people hating, ostracizing, and criminalizing us, and much of this history took place before words like "transgender," "transphobia," and analogous terms even existed. In fact, those terms were created in response to that marginalization, not the other way around. And even if I were to relinquish my trans identity, those people would still exist and continue to discriminate against me for supposedly being a sinner, or freak, or deviant, or for being delusional, or whatever other rationales they might concoct in order to justify their bigotry."

"Women who insist that trans women are not women often object to being called “cis women” under the false assumption that it somehow undermines their femaleness — this is not at all the purpose of this language. The sole purpose of cis terminology is to name the unmarked majority (similar to how one might refer to white women, or heterosexual women, or able-bodied women, etc.). In other words, referring to someone as “cisgender” simply means that they have not had a transgender experience."

"Trans women differ greatly from one another. Perhaps the only thing that we share in common is a self-understanding that there was something wrong with our being assigned a male sex at birth and/or that we should be female instead. While some cisgender people refuse to take our experiences seriously, the fact of the matter is that transgender people can be found in virtually every culture and throughout history; current estimates suggest that we make up 0.2 – 0.3% of the population [or possibly more]. [...] In other words, we simply exist."

"Like women more generally, many trans women are feminists. Feminism and transgender activism are not in any way incompatible or mutually exclusive. As feminists who acknowledge intersectionality, we believe that we should be fighting to end all forms of sexism and marginalization — this includes both traditional sexism and transphobia. Forcing trans women into a separate group that is distinct from cis women does not in any way help achieve feminism’s central goal of ending sexism."

"Claims that trans women are not women often rely on essentialist (and therefore incorrect) assumptions about biology. For instance, people might argue that trans women are not “genetically female,” despite the fact that we cannot readily ascertain anybody’s sex chromosomes. Indeed, most people have never even had their sex chromosomes examined, and those that do are sometimes surprised by the results. Other common appeals to biology center on reproduction — e.g., stating that trans women have not experienced menstruation, or cannot become pregnant. This ignores the fact that some cisgender women never menstruate and/or are unable to become pregnant. Claims about genitals are similarly problematic: Women’s genitals vary greatly, and as with chromosomes and reproductive capabilities, we cannot readily see other people’s genitals in everyday encounters. If you and I were to meet, should I refuse to recognize or refer to you as a woman unless you show me your genitals? And frankly, what could possibly be more sexist than reducing a woman to what’s between her legs? Isn’t that precisely what sexist men have been doing to women for centuries on end?"

"While gender socialization is quite real, all of us are capable of overcoming or transcending the socialization that we experienced as children. And gender socialization doesn’t simply stop when one reaches adulthood: All of us are constantly facing gender-related social pressures, expectations, and obstacles throughout our lives. If you believe that these statements are true for cis women, then they also must be true for trans women."

"Trans women do not transition out of a desire to be feminine; we transition out of a self-understanding that we are or should be female (commonly referred to as gender identity)."

"Trans women who are conventionally feminine are not in any way asserting or insinuating that all women should be conventionally feminine, or that femininity is all there is to being a woman. Like cis women, trans women dress the way we do in order to express ourselves, not to critique or caricature other women."

"As a trans woman, I will be the first to admit that I cannot possibly know what any other woman experiences or feels on the inside. But the thing is, the trans-women-aren’t-women crowd cannot possibly know what any other woman experiences or feels either! Every woman is different. We share some overlapping experiences, but we also differ in every possible way. Every trans woman I know acknowledges this diversity. In contrast, it’s the cis women who attempt to exclude us who seem to have a singular superficial stereotypical notion of what constitutes a woman, or of what women experience."

"Trans women are women. We may not be “exactly like” cis women, but then again, cis women are not all “exactly like” one another either. But what we do share is that we all identify and move through the world as women. And because of this, we all regularly face sexism. That is what we should be focusing on and working together to challenge. And as I said at the outset, forcing trans women into a separate group that is distinct from cis women does not in any way help achieve feminism’s central goal of ending sexism. In fact, it only serves to undermine our collective cause."

"People tend to harbor essentialist beliefs about sex — that is, they presume that each sex category has an underlying "essence" that makes them what they are. This is what leads people to assume that trans women remain "biologically male" despite the fact that many of our sex characteristics are now female. However, there is no “essence” underlying sex; it is simply a collection of sexually dimorphic traits. Some people will presume that sex chromosomes must be this "essence," even though we cannot readily see them, plus there are non-XX or XY variants. Others presume that genitals are this "essence" (probably because they are used to determine our birth-assigned and legal sex), although they can vary too, and may eventually change (e.g., if one undergoes sex reassignment surgery). In day-to-day life, we primarily rely on secondary sex characteristics to determine (or more precisely, presume) what sex a person is — and of course, these traits may change via a simple hormone prescription. Like I said, there is no mystical “essence” underlying sex."

"Sex is a collection of traits that, while generally dimorphic, can vary greatly in the population, and some can change over time. While the terms "male" and "female" have some utility, we should not view them as strictly dichotomous or mutually exclusive. Rather, “female” and “male” are best thought of as umbrella terms that describe groupings of people (or animals) who generally share many of the same traits, albeit with considerable variability and some exceptions."

"The most infuriating assertion regularly made by the "trans women are biologically male" camp is that trans people are somehow "denying" or "erasing" biological sex differences, and that this hurts cisgender women/"[w:Female|biological females]].” This is patently untrue. I can assure you that trans people are highly aware of biological sex differences — the fact that many of us physically transition demonstrates that we acknowledge that sexually dimorphic traits exist and may be important to some people! I would reframe things this way: Transgender people often have a more complicated relationship with our sex-related traits (as they may be discordant with our identified and lived genders), and thus the language that we use to describe or discuss these traits may seem arcane, or nonsensical, or unnecessary to the average cisgender person. And because they are unfamiliar with this language (and/or flat-out antagonistic toward us), some cisgender people will subsequently misinterpret this language and differing perspective as some sort of "denial.""

"Science is not a subject, it's a method. And the method can be applied to anything. Anybody can be a scientist."

"There is a molecular rhythm to life in terms of development"

"Weightlifting is great – makes you feel like Superman. But you lose the edge on flexibility."

"Every movement in the skies or upon the earth proclaims to us that the universe is under government."

"Time, to the nation as to the individual, is nothing absolute; its duration depends on the rate of thought and feeling."

"Four years after the death of Justinian, A.D. 569, was born at Mecca, in Arabia, the man who, of all others, has exercised the greatest influence upon the human race—Mohammed… To be the religious head of many empires, to guide the daily life of one third of the human race, may perhaps justify the title of a messenger of God."

"The Koran abounds in excellent moral suggestions and precepts; its composition is so fragmentary that we can not turn to a single page without finding maxims of which all men must approve. This fragmentary construction yields texts, and mottoes, and rules complete in themselves, suitable for common men in any of the incidents of life."

"I have to deplore the systematic manner in which the literature of Europe has contrived to put out of sight our scientific obligations to the Mohammedans. Surely they can not be much longer hidden. Injustice founded on religious rancor and national conceit can not be perpetuated forever. … The Arab has left his intellectual impress on Europe, as, before long, Christendom will have to confess; he has indelibly written it on the heavens, as any one may see who reads the names of the stars on a common celestial globe."

""But, though the Church hath evermore from Holy Writ affirmed that the earth should be a wide-spread plain bordered by the waters, yet he [Magellan] comforted himself when he considered that in the eclipses of the moon the shadow cast of the earth is round; and as is the shadow, such, in like manner, is the substance." It was a stout heart - a heart of triple brass - which could thus, against such authority, extract unyielding faith from a shadow."

"The early composition of my lab at Berkeley, in fact really the core people that did the work that the Nobel Foundation has recognized me for, if you look at that group of people they are far more diverse than certainly at that time you would see in the average chemistry laboratory. I had a preponderance of female grad students at a time when our representation in the graduate program at Berkeley was maybe 30%, but my lab was over half. I had people from different backgrounds, people who identify as underrepresented minorities, and I think that diversity of people created an environment where we felt we didn't have to play by the same old rules as scientists. We could do things like organic chemistry in living animals. Why not? Right? We didn't have to play by the rules. If there weren't the right chemistries to get the job done, we could invent new chemistries. Why not? We didn't have to play by the rules. And I think that culture, it kind of grew organically, no pun intended, without a whole lot of steering by myself. I was very fortunate that I could actually play a supportive role in my lab and let that diverse group of students find their voice, realize their curiosity, break the rules, and do something that 25 years later some people found impactful. And I owe them a great debt of gratitude."

"When the world is in trouble, chemistry comes to the rescue."

"Okay so Adam is there anything, do I have action items here?"

"Implicit in the devotion to purifying enzymes, is the faith of a dedicated biochemist of being able to reconstitute in a test tube anything a cell can do."

"These scientists, once young and eager, had become gnomes grappling hopelessly with problems far beyond their reach."

"I had this impression from the media that science was for old white guys, people who looked like Einstein, that it wasn’t for people like me ..."

"... CRISPR is, in fact, a bacterial immune system. It’s an ancient system that evolved in microbes to allow prevention of viral infection. Our interest in this started with that fundamental biology, asking, “How does this work?” We did a collaborative research project with Emmanuelle Charpentier, a medical microbiologist, and our work with her laboratory revealed that one of the components of this CRISPR immune system is, in fact, a protein that’s called , that can be programmed to find and cut virus DNA. We published this work back in the summer of 2012, and for me, life hasn't been the same since."

"... I just think you have to embrace your passions. You have to really go for it. People that have been less successful, in my opinion, are those that dabble in something, but then don’t really give it their all. They almost never give themselves a chance to succeed, as they back off too soon. I think for young people, I tell them go for it, find supportive mentors who will help you through the tough times, and then just keep going. Because if you have a good idea, it’s probably going to work out in some way. You may not be able to predict how, but you should just keep pursuing it."

"When I was taught biology, we learned about the structure and code of DNA, and we learned about how proteins do all the heavy lifting in cells, and RNA was treated as this dull intermediary, sort of a middle manager ... I was quite surprised that there was this young genius, Jack Szostak, at Harvard who wanted to focus a hundred percent on RNA because he thought that it was the key to understanding the origin of life."

"... it's kind of a catchy acronym. It stands for Clusters of Regularly Interspaced Short Palindromic Repeats. Oh! Don't make me say that again. ... What it means — what it symbolizes — is an immune system in bacteria that uses sequences of DNA (that come originally from viruses) ... that are transcribed into molecules of RNA that can use a search-and-destroy mechanism in cells to find and cut up virus genetic material"

"Two years ago, I was working on my laptop in an airport lounge in Newark, New Jersey, when I glanced up and saw a couple walking with their two boys. The younger boy slowly made his way on crutches, displaying the telltale signs of a hereditary disease called muscular dystrophy. Generally manifesting in childhood, the disease steadily robs those who have it of their ability to walk. Eventually, I knew, the crutches would no longer be enough. My heart skipped a beat. Most types of muscular dystrophy originate with genetic mutations that weaken key muscle proteins, and I had just come from a meeting where a cure appeared possible, using CRISPR technology to rewrite the DNA of kids just like him. Imagining how the technology I’d helped create could change this boy’s life, I was overwhelmed with emotion. Beyond hope and wonder, I was filled with a sense of fierce urgency to expand CRISPR’s impact to the people around the world who need it most."

"On a new derivation of Birkhoff's strong ergodic hypothesis he once remarked in exasperation: "To be any more immaculate they will have to begin sterilizing the paper as well as the theorem !""

"... he gave a seminar in Oxford about his ideas on liquid helium, but on this occasion even the theorists were baffled. Onsager's final comment in reply to a question was: "The results are not bad when you consider the enormity of the swindle which I have perpetrated!""

"Of the electroencephalogram he once remarked: "It is like trying to discover how the telephone system works by measuring the fluctuations in the electric power used by the telephone company.""

"There's a time to soar like an eagle and a time to burrow like a worm. It takes a pretty sharp cookie to know when to shed the feathers and (long pause) to begin munching the humus! (characteristic Onsager giggle)."

"There are a lot of folks, some quite talented, who arm themselves with methods and then go hunting for vulnerable problems; but to accept a problem on its own terms and then forge your own weapon--now that's real class!"

"They made the mistake there of assigning Onsager to the basic Chemistry I, II course. He just couldn't think at the level of a freshman. Frankly, he was fired. I won't say he was the world's worst lecturer, but he was certainly in contention. He was difficult to understand anyway, but he also had the habit of lecturing when his back was to the students and he was writing on the blackboard. To compound matters, he was a big man, and students had to peer round him just to try and see what was being written."

"In the days of Kepler and Galileo, it was fashionable to announce a new scientific result through the circulation of a cryptogram which gave its author priority and his colleagues headaches. Onsager is one of the few moderns who operates in this tradition."

"... a reluctance to publish anything except fully-polished work, combined with the habit of dropping valuable hints couched in gnomic terms. The obscurity of his utterances is not due to a desire to mislead; rather it is a result of an inability to appreciate the limitations of his hearers. To those who have been able to appreciate what he tries to say, he has been a source of deep stimulation."

"He had been warned that non-theoreticians would be present and that he should phrase his talk in not too technical language. He plunged, nevertheless, into the mathematics of spinor algebras. After about twenty minutes, one of the many experimentalists in the audience had the courage to ask him what a spinor was. Onsager replied, thoughtfully: "A spinor--no, a set of spinors--is a set of matrices isomorphic to the orthogonal group." With that he gave the famous Onsager grin, twinkled his Nordic blue eyes at the bewildered faces around him, and continued the lecture as if nothing had happened."

"Onsager regarded chess, so he said, as too much like real problem-solving to spend much time on it. When he wanted to unwind from his work he would play solitaire, and bridge was a good relaxation in company."

"... when asked by Longworth how he would explain the electrophoretic effect in "physical terms," he picked up Longsworth, chair and all, and carried him across the room."

"One day Onsager told him he had decided to try an experiment on the separation of isotopes by thermal diffussion. "Fine," said Kraus, and was doubly pleased when Lars told him that the only equipment he would need was a long tube. But his encouragement was quickly withdrawn when Onsager explained that the tube must be made of platinum and would have to stretch from the basement to the third floor of the chemistry building. Kraus never pestered him again about doing an experiment, which "was too bad," writes Julian Gibbs, "because no one succeeded in conducting this experiment until more than a decade later, when it was needed as part of the Manhattan Project for the atomic bomb.""

"Pauli judging the World War II period in physics wrote in a letter to Casimir: “Nothing much of interest has happened except for Onsager’s exact solution of the Two-Dimensional Ising Model.”"

"In 1944, E. Onsager produced, quite unexpectedly, an exact evaluation of the partition function of the model in two dimensions. It was a real tour de force. I had studied his paper in Chicago in the spring of 1947, but did not understand the method, which was very, very complicated, with many algebraic somersaults... I was thus led to a long calculation, the longest in my career. Full of local, tactical tricks, the calculation proceeded by twists and turns. There were many obstructions. But always, after a few days, a new trick was somehow found that pointed to a new path... after about six months of work off and on, all the pieces suddenly fitted together, producing miraculous cancellations, and I was staring at the amazingly simple final result[, the spontaneous magnetization of the ising model.]"

"... More explicitly than ever before the modern principles of physical science seem to compel us to recognized absolute mechanical necessity in all things. We may not understand organic regulations, or organic evolution, or the origin of life; in fact we are still unable with the necessary clearness to represent to ourselves the structure of a cell; yet theses are at least phenomena. As phenomena they are subject to the two laws of thermodynamics. For the laws of conservation and degradation of energy have long since supplanted Leibniz's rudimentary idea of the conservation of ', as the ground of our conception of necessary causation."

"It is in proportion to our success or failure in conceiving facts simply that sciences are abstract or concrete, rational or descriptive. In these respects the contrast is great between the physical and the biological sciences. The figure of the earth, its path about the sun, and its relations to the other planets are readily conceivable in a first approximation as simple; but the forms of life seem complex, their activities manifold, and the concatenations interminable. Therefore, unlike celestial mechanics, the science of biology, which is the record of efforts accurately to describe and clearly to understand living things, is chiefly a science descriptive of concrete fact. It bears little resemblance to the more perfect science and as yet is in no danger of a relativist revolution. It has never attained, perhaps, as some have argued, it can never in any respect achieve and should not strive for the abstractness, the elegance, and the simplicity which are the mark of the classical epoch of many the physical sciences and the ideal of those who follow Newton and Willard Gibbs."

"Four centuries ago, Machiavelli was thinking of certain great problems of human society and writing two famous books. In so doing he reached scientific generalizations about the influence of the sentiments upon the actions of men and, through these actions, upon the fate of human societies. As a whole, these conclusions stand; but from this great and ingenious work of Machiavelli's almost no developments have followed. The science of statecraft and of the influence of the sentiments upon human behavior is little different to-day from what it was in in the 16th century."

"Science, that was going to save the world in H. G. Wells' time, is regimented, strait-jacketed, scared shitless, its universal language diminished to one word, security."

"I grew up on U.S. military bases in Korea and Japan. My father emigrated from Korea and worked at the U.S. embassies in Seoul and Tokyo. My mother was a finance clerk at the embassy. I have one brother who’s an engineer and builds airplanes."

"I was always interested in science. When John Glenn became the first American to orbit the Earth, I remember riding my tricycle and thinking that I too wanted to be an astronaut. Later, when I became an assistant professor at the University of Colorado, three of my first lab members had segued into biochemistry after first starting in aerospace engineering. So I appreciate how NASA and other big-science efforts promote science by inspiring kids."

"After finishing a high school degree overseas, I majored in chemistry at the University of Washington in Seattle and did undergraduate research in X-ray crystallography with the late Lyle Jensen and protein hydrodynamics with David Teller. I obtained my Ph.D. in chemistry from the University of California, Berkeley, where I studied enzymology with Judith Klinman. Judith is an incredibly deep thinker as well as a generous and courageous individual who continues to be one of my greatest inspirations."

"My first postdoctoral job was with Christoph de Haën at the University of Washington, where I studied hormone receptor binding. Christoph was unable to renew his funding and had to close his lab, and that’s how I learned about the importance of grants! He ended up great anyway, eventually becoming director of preclinical research at Bracco and director of the Milano Research Center. I then moved to the lab of the late Edwin Krebs for a second postdoc, where I was among the first to describe MAP kinases and MAP kinase kinases. That started my career in signal transduction."

"I still work on MAP kinase and other signaling pathways. When I started at the University of Colorado, I began applying the new technology of protein mass spectrometry to address questions in signaling. This was done in collaboration with my late partner, Katheryn Resing. My lab’s applications of proteomics to signal transduction have led to broad discoveries, ranging from new mechanisms for cell regulation to mechanisms for allosteric control of MAP kinases."

"I attended the ASBMB annual meeting during my graduate studies, and it was at this meeting that I gave my first public research talk and got to meet the leaders in enzymology. That was a spectacular experience. When at the end of my first postdoc I had no way to pay for an accepted manuscript, the Journal of Biological Chemistry generously waived page charges, allowing me to publish. Since then, I’ve helped organize symposia at the annual meeting and served on the ASBMB Council. It was the support by the ASBMB during the crucial early years of my career that engendered my long-lasting love for this society."

"I try to be involved in every aspect of my lab, but I let my students and postdocs — currently eight in all — work independently enough to discover their strengths, while following behind to support them. That’s not too different from the way I view leadership elsewhere, where my instinct is to try to solve the most important problems and avoid fixing what’s not broken."

"I’m not a flashy or provocative person, although I am unafraid of taking a stand when it’s important. As president, I plan to focus on gaps and weaknesses at the ASBMB and the detailed steps needed to address them."

"Right now, we have three priorities. First is to recapture the annual meeting’s reputation as a must-attend event. Second is to expand our visibility and membership, especially among young investigators. Third is to restore the prominence and stature of the Journal of Biological Chemistry, where we’ve been fortunate to appoint Lila Gierasch as editor-in-chief and Fred Guengerich as deputy editor."

"The ASBMB has profoundly influenced discovery, and the importance of BMB in our current era is growing, not shrinking. This is obvious just by looking at the approximately one-third of human open reading frames and majority of noncoding RNAs whose functions are unknown and the overwhelming numbers of new regulatory connections generated from large-scale studies. Our discipline is the cornerstone of what’s needed to discover the functions of new molecules and mechanisms underlying their connectios."

"That experience taught me about making decisions and to just keep going but to always maintain your dignity."

"I knew how to get out because I could read and I had to get out because the environment was dangerous."

"And, today, I’m grateful to Miss Ann, for showing me a direction I didn’t want to take."

"For the first 18 years of my career, I was the only Black woman in my field. When I was in the Navy, I was the only Black girl in my division. Afterwards in my lab, I was the only Black woman in the whole facility – and initially they thought I was the janitor."

"You feel like you have to represent your entire race and descend the racial stereotypes … especially in nuclear and radiochemistry."

"I thought about me — as a little girl, desperately looking for someone like me in science who was an inspiration, and it changed my perspective."

"I wanted to go to a Black college to allow the students to have the opportunity to get the kind of education that I had gotten; because I felt coming from where I came from that it was almost impossible for me to get the kind of training I had gotten. (...) I squeezed through the wire mesh fence."

"You must love chemistry; you must be committed; and you must prove yourself over and over."

"If I was talking to someone I mentor, I would say to make sure that you’re comfortable in your own skin. I don’t care what job you have. You need to know who you are, and then you look for a place that wants who you are. Then you go and do the best you can, being who you are authentically. And I think that’ll work."

"Having left various roles and come into different roles, I pride myself on being a good leaver. I just left Duke University, which I loved and still love, and I don’t allow anybody to talk to me about anything there."

"It is a privilege to be in leadership, and we are indeed in service to people."

"We will advance knowledge, economic prosperity and social justice by welcoming and inspiring inquisitive minds from all backgrounds."

"I work and work and still it seems I have nothing done."

"Courage is like — it’s a habitus, a habit, a virtue: you get it by courageous acts. It’s like you learn to swim by swimming. You learn courage by couraging."

"In those days, it was common for a woman to be addressed as ‘Miss’ even though she had earned a Ph.D. degree."

"Rockefeller, where she worked for seven years, was an “awesome and inspiring” place to be."

"Our goal is to design systems that can be activated by light to selectively target cancer cells, while leaving healthy cells unharmed."

"By understanding how molecules absorb and use light, we can create new approaches that address some of the most difficult problems in medicine."

"We’re using the power of supercomputing to see things no microscope can—how viruses move, interact, and evolve."

"I went into chemistry instead of engineering because I thought engineers drove trains."

"It's estimated that 30 percent of type II diabetes patients have NASH [nonalcoholic steatohepatitis, a severe form of fatty liver disease]."

"That's right. That's right. They were scientists involved in public health. And for that reason, I always was encouraged to explore science, math, as well as all of the broader fields of social and physical sciences."

"Yes, I was academically inclined. I was the good student. I raised my hand a lot. I got good grades, and I tended to be very much engaged with my teachers. I tended to know my teachers very well."

"Since my freshman year of high school, I have been intrigued by RNA. I conducted my Ph.D. research in Jennifer Doudna’s lab where I was the first student to work on CRISPR. Based on work that was done in her lab, we co-founded Caribou Biosciences with two other scientists. I wanted to transition from academia to industry to have a more direct impact through science on my community. Today at Caribou, our goal is to help realize the promise of CRISPR genome-editing technology and to develop new, potentially transformative cell therapies to help patients with devastating diseases. A role in industry provides me the opportunity to contribute to the development of new therapies for patients that could have a meaningful impact on their lives."

"I thought that being a company co-founder would be an amazing opportunity (and I was right!). Founding Caribou was risky. We did not know if we’d be able to raise money, hire a team, and ultimately build a successful organization. However, it was an exciting challenge I feel really lucky to have jumped into. As a company co-founder, and especially as the founding president and CEO, I’ve had the opportunity to work with many talented colleagues and lead Caribou to achieve some important milestones, including dosing the first patient in our phase 1 clinical trial for our first allogeneic cell therapy, CB-010, and completing a successful $350 million IPO."

"I always believed that if you just like laid down the facts, provided the evidence, that people would go along with what was best for humanity. And that has not been the case during this pandemic. That has killed me."

"An aerosol is a stable suspension of solid or liquid particles in the air. They come out of someone’s mouth, or they come out of a smokestack, or they come out of the tailpipe, and you watch them, they don’t fall to the ground. They float and waft off into the sky."

"Maybe it’s time to rethink what we value as strengths and signs of leadership."

"I realized I was the only woman on the list. There were 12 names, and I was the only one, it shocked me. Most of my women friends are scientists. They are doing extremely well — why don’t they get the top jobs?"

"With men, the response is often led with the person’s accomplishments. With women, it is often initially focused on style and behavior; capabilities come second."

"So many problems in society have a technical solution rooted in chemistry: sustainable energy, food security, clean water, personalised medicine."

"I was always interested in understanding the natural world, even as a child. I wondered if milk was a pure liquid or whether it was a mixture of things in water, at about age 8. In later schooling, physics seemed boring, biology was messy, and chemistry was just right."

"I was like wishing I had a time machine, and I could go back to myself and like, punch myself in the face, actually. It wasn’t even like say no, it was like, physically remind myself that I didn’t like to do that."

"There are more tasks to do than there are time to do them."

"I will discuss mechanistic studies of the factors that contribute to these PTM-mediated protein-protein interactions using a combination of high-throughput mechanistic screening, genetic code expansion, and investigation of PTM-isosteres, and how this has led to novel approaches to inhibit them."

"Post-translational modifications, PTMs, in histone proteins, including lysine methylation and acylation, regulate gene expression through recruitment of reader proteins to the nucleosome. Dysregulation of these events is prevalent in a wide range of diseases, such that there is much interest in characterizing these modifications and their binding partners as well as developing inhibitors for these protein-protein interactions."

"Developing novel medicines is hard. Most of the time, compounds don’t make it all the way through to development, so to be part of a project that made it through commercial launch to have a direct impact on so many patients is incredible."

"That early read out was a sign that what we were doing was incredibly efficacious in the field."

"A previous publication reported the occurrence of in the eyes of all rats fed on rations containing as the chief source of . Negative results with other carbohydrates tested led to an investigation of as the next logical step. This sugar was fed to young rats at 35% and 25% levels corresponding to the galactose available from the 70% and 50% lactose rations fed in previous experiments. Four rats on the 35% galactose ration developed mature bilateral cataract in 12, 14, 14, and 37 days respectively (average 19 days), whereas those on the 25% galactose ration were somewhat more delayed. The average time for the development of mature bilateral cataract in 49 rats fed the 70% lactose ration was 10 weeks, approximately 4 times as long. Controls fed on the 70% starch ration showed no eye changes."

"... Even minor during the growing period may prevent full potential growth from being attained. ... Growth potential is not a thing that can be speeded up and lowed down and still obtain the same end results. According to ..., if one does not use the full potential alI the way along, one does not achieve full development. The same ultimate weight may be reached but not the ideal shape and composition. If the rate of growth is sufficiently slowed down, the adult is not only smalI but under-developed with normal or nearly normal head size, moderately retarded trunk and relatively short legs."

"(quote from p. 521)"

"Remember that there were no in the 1920's, and every had to depend on a few recognized authorities for estimates of needs of children. In 1923, called attention ... to the protein needs for optimal growth in rats which he estimated to be about 15 per cent of the calories. He contrasted that with which provides only 7 per cent of the calories in the form of protein, to provide for the growth of the infant. He also emphasized what and had demonstrated earlier that animal proteins were more efficient for growth than plant proteins."