First Quote Added
April 10, 2026
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"It is important to distinguish between the amount of information and the quality of that information."
"At any rate, both because of the clear trend in the recent history of biology and because there is not a shred of evidence to support it, I will not in these pages entertain any hypotheses on what used to be called the mind-body dualism, the idea that inhabiting the matter of the body is something made of quite different stuff, called mind."
"Those at too great a distance may, I am well aware, mistake ignorance for perspective."
"The entire recent history of biology shows that we are, to a remarkable degree, the results of the interactions of an extremely complex array of molecules; and the aspect of biology that was once considered its holy of holies, the nature of the genetic material, has now been fundamentally understood in terms of the chemistry of its constituent nucleic acids, DNA and RNA, and their operational agents, the proteins."
"Absence of evidence is not evidence of absence."
"My fundamental premise about the brain is that its workings—what we sometimes call “mind”—are a consequence of its anatomy and physiology, and nothing more."
"I proffer the following ideas with a substantial degree of trepidation; I know very well that many of them are speculative and can be proved or disproved on the anvil of experiment."
"I think the ratio, R, of the time to sense the dose taken to the time required to take an excessive dose is an important quantity. R is very large for LSD (which I've never taken) and reasonably short for cannabis. Small values of R should be one measure of the safety of psychedelic drugs. When cannabis is legalized, I hope to see this ratio as one of the parameters printed on the pack. I hope that time isn't too distant; the illegality of cannabis is outrageous, an impediment to full utilization of a drug which helps produce the serenity and insight, sensitivity and fellowship so desperately needed in this increasingly mad and dangerous world."
"My high is always reflective, peaceable, intellectually exciting, and sociable, unlike most alcohol highs, and there is never a hangover. Through the years I find that slightly smaller amounts of cannabis suffice to produce the same degree of high, and in one movie theater recently I found I could get high just by inhaling the cannabis smoke which permeated the theater. There is a very nice self-titering aspect to cannabis. Each puff is a very small dose; the time lag between inhaling a puff and sensing its effect is small; and there is no desire for more after the high is there."
"I can remember the night that I suddenly realized what it was like to be crazy, or nights when my feelings and perceptions were of a religious nature. I had a very accurate sense that these feelings and perceptions, written down casually, would not stand the usual critical scrutiny that is my stock in trade as a scientist. If I find in the morning a message from myself the night before informing me that there is a world around us which we barely sense, or that we can become one with the universe, or even that certain politicians are desperately frightened men, I may tend to disbelieve; but when I'm high I know about this disbelief. And so I have a tape in which I exhort myself to take such remarks seriously. I say "Listen closely, you sonofabitch of the morning! This stuff is real!" I try to show that my mind is working clearly; I recall the name of a high school acquaintance I have not thought of in thirty years; I describe the color, typography, and format of a book in another room and these memories do pass critical scrutiny in the morning. I am convinced that there are genuine and valid levels of perception available with cannabis (and probably with other drugs) which are, through the defects of our society and our educational system, unavailable to us without such drugs. Such a remark applies not only to self-awareness and to intellectual pursuits, but also to perceptions of real people, a vastly enhanced sensitivity to facial expression, intonations, and choice of words which sometimes yields a rapport so close it's as if two people are reading each other's minds."
"Incidentally, I find that reasonably good insights can be remembered the next day, but only if some effort has been made to set them down another way. If I write the insight down or tell it to someone, then I can remember it with no assistance the following morning; but if I merely say to myself that I must make an effort to remember, I never do. I find that most of the insights I achieve when high are into social issues, an area of creative scholarship very different from the one I am generally known for."
"When I'm high I can penetrate into the past, recall childhood memories, friends, relatives, playthings, streets, smells, sounds, and tastes from a vanished era. I can reconstruct the actual occurrences in childhood events only half understood at the time. Many but not all my cannabis trips have somewhere in them a symbolism significant to me which I won't attempt to describe here, a kind of mandala embossed on the high. Free-associating to this mandala, both visually and as plays on words, has produced a very rich array of insights. There is a myth about such highs: the user has an illusion of great insight, but it does not survive scrutiny in the morning. I am convinced that this is an error, and that the devastating insights achieved when high are real insights; the main problem is putting these insights in a form acceptable to the quite different self that we are when we're down the next day."
"I do not consider myself a religious person in the usual sense, but there is a religious aspect to some highs. The heightened sensitivity in all areas gives me a feeling of communion with my surroundings, both animate and inanimate. Sometimes a kind of existential perception of the absurd comes over me and I see with awful certainty the hypocrisies and posturing of myself and my fellow men. And at other times, there is a different sense of the absurd, a playful and whimsical awareness. Both of these senses of the absurd can be communicated, and some of the most rewarding highs I've had have been in sharing talk and perceptions and humor. Cannabis brings us an awareness that we spend a lifetime being trained to overlook and forget and put out of our minds. A sense of what the world is really like can be maddening; cannabis has brought me some feelings for what it is like to be crazy, and how we use that word "crazy" to avoid thinking about things that are too painful for us. In the Soviet Union political dissidents are routinely placed in insane asylums. The same kind of thing, a little more subtle perhaps, occurs here: "did you hear what Lenny Bruce said yesterday? He must be crazy.""
"Cannabis also enhances the enjoyment of sex — on the one hand it gives an exquisite sensitivity, but on the other hand it postpones orgasm: in part by distracting me with the profusion of image passing before my eyes. The actual duration of orgasm seems to lengthen greatly, but this may be the usual experience of time expansion which comes with cannabis smoking."
"The cannabis experience has greatly improved my appreciation for art, a subject which I had never much appreciated before. The understanding of the intent of the artist which I can achieve when high sometimes carries over to when I'm down. This is one of many human frontiers which cannabis has helped me traverse. There also have been some art-related insights — I don't know whether they are true or false, but they were fun to formulate."
"There's a part of me making, creating the perceptions which in everyday life would be bizarre; there's another part of me which is a kind of observer. About half of the pleasure comes from the observer-part appreciating the work of the creator-part. I smile, or sometimes even laugh out loud at the pictures on the insides of my eyelids. In this sense, I suppose cannabis is psychotomimetic, but I find none of the panic or terror that accompanies some psychoses. Possibly this is because I know it's my own trip, and that I can come down rapidly any time I want to."
"I had become friendly with a group of people who occasionally smoked cannabis, irregularly, but with evident pleasure. Initially I was unwilling to partake, but the apparent euphoria that cannabis produced and the fact that there was no physiological addiction to the plant eventually persuaded me to try. My initial experiences were entirely disappointing; there was no effect at all, and I began to entertain a variety of hypotheses about cannabis being a placebo which worked by expectation and hyperventilation rather than by chemistry. After about five or six unsuccessful attempts, however, it happened."
"Now, there has been the view that ... if there is nothing special about us in space then maybe there is something special about us in time. ... To me, the principal trouble with this idea is that 99.998% of the lifetime of the universe, from its beginning to now, was over before humans appeared on the scene."
"I think people in power have a vested interest to oppose critical thinking."
"All of the books in the world contain no more information than is broadcast as video in a single large American city in a single year. Not all bits have equal value."
"Those who raise questions about the God hypothesis and the soul hypothesis are by no means all atheists. An atheist is someone who is certain that God does not exist, someone who has compelling evidence against the existence of God. I know of no such compelling evidence. Because God can be relegated to remote times and places and to ultimate causes, we would have to know a great deal more about the universe than we do to be sure that no such God exists. To be certain of the existence of God and to be certain of the nonexistence of God seem to me to be the confident extremes in a subject so riddled with doubt and uncertainty as to inspire very little confidence indeed."
"Who is more humble? The scientist who looks at the universe with an open mind and accepts whatever it has to teach us, or somebody who says everything in this book must be considered the literal truth and never mind the fallibility of all the human beings involved?"
"That kind of skeptical, questioning, "don't accept what authority tells you" attitude of science — is also nearly identical to the attitude of mind necessary for a functioning democracy. Science and democracy have very consonant values and approaches, and I don't think you can have one without the other."
"I would love to believe that when I die I will live again, that some thinking, feeling, remembering part of me will continue. But much as I want to believe that, and despite the ancient and worldwide cultural traditions that assert an afterlife, I know of nothing to suggest that it is more than wishful thinking. The world is so exquisite with so much love and moral depth, that there is no reason to deceive ourselves with pretty stories for which there's little good evidence. Far better it seems to me, in our vulnerability, is to look death in the eye and to be grateful every day for the brief but magnificent opportunity that life provides."
"Something dreadful happens to students between first and twelfth grades, and it's not just puberty."
"Every kid starts out as a natural-born scientist, and then we beat it out of them. A few trickle through the system with their wonder and enthusiasm for science intact."
"If you take a look at science in its everyday function, of course you find that scientists run the gamut of human emotions and personalities and character and so on. But there's one thing that is really striking to the outsider, and that is the gauntlet of criticism that is considered acceptable or even desirable. The poor graduate student at his or her Ph.D. oral exam is subjected to a withering crossfire of questions that sometimes seem hostile or contemptuous; this from the professors who have the candidate's future in their grasp. The students naturally are nervous; who wouldn't be? True, they've prepared for it for years. But they understand that at that critical moment they really have to be able to answer questions. So in preparing to defend their theses, they must anticipate questions; they have to think, “Where in my thesis is there a weakness that someone else might find — because I sure better find it before they do, because if they find it and I'm not prepared, I'm in deep trouble.""
"The truth may be puzzling. It may take some work to grapple with. It may be counterintuitive. It may contradict deeply held prejudices. It may not be consonant with what we desperately want to be true. But our preferences do not determine what's true. We have a method, and that method helps us to reach not absolute truth, only asymptotic approaches to the truth — never there, just closer and closer, always finding vast new oceans of undiscovered possibilities. Cleverly designed experiments are the key."
"In fact, the thickness of the Earth's atmosphere, compared with the size of the Earth, is in about the same ratio as the thickness of a coat of shellac on a schoolroom globe is to the diameter of the globe. That's the air that nurtures us and almost all other life on Earth, that protects us from deadly ultraviolet light from the sun, that through the greenhouse effect brings the surface temperature above the freezing point. (Without the greenhouse effect, the entire Earth would plunge below the freezing point of water and we'd all be dead.) Now that atmosphere, so thin and fragile, is under assault by our technology. We are pumping all kinds of stuff into it. You know about the concern that chlorofluorocarbons are depleting the ozone layer; and that carbon dioxide and methane and other greenhouse gases are producing global warming, a steady trend amidst fluctuations produced by volcanic eruptions and other sources. Who knows what other challenges we are posing to this vulnerable layer of air that we haven't been wise enough to foresee?"
"Humans — who enslave, castrate, experiment on, and fillet other animals — have had an understandable penchant for pretending animals do not feel pain. A sharp distinction between humans and 'animals' is essential if we are to bend them to our will, make them work for us, wear them, eat them — without any disquieting tinges of guilt or regret. It is unseemly of us, who often behave so unfeelingly toward other animals, to contend that only humans can suffer. The behavior of other animals renders such pretensions specious. They are just too much like us."
"The idea that God is an oversized white male with a flowing beard who sits in the sky and tallies the fall of every sparrow is ludicrous. But if by God one means the set of physical laws that govern the universe, then clearly there is such a God. This God is emotionally unsatisfying... it does not make much sense to pray to the law of gravity."
"We live in a society absolutely dependent on science and technology and yet have cleverly arranged things so that almost no one understands science and technology. That's a clear prescription for disaster."
"In science it often happens that scientists say, "You know that's a really good argument; my position is mistaken," and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion."
"It seems to me what is called for is an exquisite balance between two conflicting needs: the most skeptical scrutiny of all hypotheses that are served up to us and at the same time a great openness to new ideas ... If you are only skeptical, then no new ideas make it through to you ... On the other hand, if you are open to the point of gullibility and have not an ounce of skeptical sense in you, then you cannot distinguish the useful ideas from the worthless ones."
"Imagine, a room, awash in gasoline. And there are two implacable enemies in that room. One of them has 9,000 matches. The other has 7,000 matches. Each of them is concerned about who's ahead, who's stronger. Well, that's the kind of situation we are actually in. The amount of weapons that are available to the United States and the Soviet Union are so bloated, so grossly in excess of what's needed to dissuade the other that if it weren't so tragic, it would be laughable."
"There is a place with four suns in the sky — red, white, blue, and yellow; two of them are so close together that they touch, and star-stuff flows between them. I know of a world with a million moons. I know of a sun the size of the Earth — and made of diamond. There are atomic nuclei a few miles across which rotate thirty times a second. There are tiny grains between the stars, with the size and atomic composition of bacteria. There are stars leaving the Milky Way, and immense gas clouds falling into it. There are turbulent plasmas writhing with X- and gamma-rays and mighty stellar explosions. There are, perhaps, places which are outside our universe. The universe is vast and awesome, and for the first time we are becoming a part of it."
"It is easy to create an interstellar radio message which can be recognized as emanating unambiguously from intelligent beings. A modulated signal (‘beep,’ ‘beep-beep,’ . . . ) comprising the numbers 1, 2, 3, 5, 7, 11, 13, 17, 19, 23, 29, 31, for example, consists exclusively of the first 12 prime numbers—that is, numbers that can be divided only by 1, or by themselves. A signal of this kind, based on a simple mathematical concept, could only have a biological origin. . . . But by far the most promising method is to send pictures."
"I do not regard the late Carl Sagan as any kind of authority. On the contrary, as this book will show, I regard him in many ways as a dubious publicity seeker and careerist, more concerned to maintain his reputation as the brilliant and sceptical representative of hard-headed science than to look squarely and honestly at the facts. In short, a bit of a crook."
"I was applying to colleges in high school and I already knew I wanted to study the universe at age seventeen because I knew at age nine. So my applications were dripping with the universe. I was accepted at Cornell, and it's time to decide what school you go to, and a set of other schools as well. The admissions office, unknown to me, sent my application to Carl Sagan. He was already famous. He was already on Johnny Carson, Tonight Show. To get him to just comment on it. Carl Sagan then sent me a letter, hand signed, saying, 'I understand you're considering Cornell. If you come by and visit I'd be happy to show you the lab.' And I said, 'Is this Carl Sagan?' I showed it to mom, dad, I said, 'Could this be?' And it was. I wrote back and I said, 'Yeah, I'll go up in two weekends.' He met me on a Saturday morning in the snow, gave me a tour of his lab. I'm in his office, he reaches back, pulls out one of his books, signs it to me. It's time for me to leave, he drives me to the bus station, snowing a little heavier. He writes his home phone on a sheet of paper, says, 'If the bus can't get through, call me, spend the night at our place.' And I thought to myself, who am I? I'm just some high school kid. And to this day, to this day, I have this duty to respond to students who are inquiring about the universe as a career path, to respond to them in the way that Carl Sagan had responded to me."
"Carl Sagan... examined the cures from cancer that resulted from a visit to Lourdes... where people were healed by a simple contact with the holy waters, and found... that, of the total cancer patients who visited... the cure rate was, if anything, lower than the statistical one for s. It was lower than the average for those who did not go to Lourdes. Should a statistician infer that... odds of survival deteriorate after a visit..?"
"Sagan's first wife, Lynn Margulis, was one of the principal architects of the Gaia Hypothesis. Put their viewpoints together, and the conclusion you would reach would be that nuclear war could have a significant enough effect that it could even kill Gaia."
"As astronomer Carl Sagan thought about what Fermi said Fermi paradox], he began to be alarmed. ...This could only mean that advanced civilizations destroy themselves before they get that far, a viewpoint Sagan published in 1966."
"The work of Carl Sagan has been a profound influence in my life, and the life of every individual who recognizes the importance of humanity's ongoing commitment to the exploration of our universe."
"Inspired by the impact hypothesis, a group of astrophysicists led by Carl Sagan decided to try to model the effects of an all-out war and came up with the concept of "nuclear winter," which, in turn, generated its own wave of media coverage."
"Astronomer Carl Sagan noted that even when it is viewed from so far away that it is a pale dot, Earth is discernibly blue."
"When my husband died, because he was so famous and known for not being a believer, many people would come up to me—it still sometimes happens—and ask me if Carl changed at the end and converted to a belief in an afterlife. They also frequently ask me if I think I will see him again. Carl faced his death with unflagging courage and never sought refuge in illusions. The tragedy was that we knew we would never see each other again. I don't ever expect to be reunited with Carl. But, the great thing is that when we were together, for nearly twenty years, we lived with a vivid appreciation of how brief and precious life is. We never trivialized the meaning of death by pretending it was anything other than a final parting. Every single moment that we were alive and we were together was miraculous-not miraculous in the sense of inexplicable or supernatural. We knew we were beneficiaries of chance. ... That pure chance could be so generous and so kind. ... That we could find each other, as Carl wrote so beautifully in Cosmos, you know, in the vastness of space and the immensity of time. ... That we could be together for twenty years. That is something which sustains me and it's much more meaningful. ... The way he treated me and the way I treated him, the way we took care of each other and our family, while he lived. That is so much more important than the idea I will see him someday. I don't think I'll ever see Carl again. But I saw him. We saw each other. We found each other in the cosmos, and that was wonderful."
""This is a deathwatch," Carl told me calmly. "I'm going to die." "No," I protested. "You're going to beat this, just as you have before when it looked hopeless." He turned to me with that same look I had seen countless times in the debates and skirmishes of our twenty years of writing together and being wildly in love. With a mixture of knowing good humor and skepticism, but as ever, not a trace of self-pity, he said wryly, "Well, we'll see who's right about this one." Sam, now five years old, came to see his father for one last time. Although Carl was by now struggling for breath and finding it harder to speak, he managed to compose himself so as not to frighten his little son. "I love you, Sam," was all he could say. "I love you, too, Daddy," Sam said solemnly. Contrary to the fantasies of the fundamentalists, there was no deathbed conversion, no last minute refuge taken in a comforting vision of a heaven or an afterlife. For Carl, what mattered most was what was true, not merely what would make us feel better. Even at this moment when anyone would be forgiven for turning away from the reality of our situation, Carl was unflinching. As we looked deeply into each other's eyes, it was with a shared conviction that our wondrous life together was ending forever."
"We can judge our progress by the courage of our questions and the depths of our answers, our willingness to embrace what is true rather than what feels good."
"The fact is that far more crime and child abuse has been committed by zealots in the name of God, Jesus and Mohammed than has ever been committed in the name of Satan. Many people don't like that statement, but few can argue with it."
"You can't convince a believer of anything; for their belief is not based on evidence, it's based on a deep seated need to believe."