nobel-laureates-from-england

"The idea that there might exist small particles with no electrical charge has been put forward several times. , for example, suggested that a neutral particle might be formed by a negative electron and an equal positive charge, and that these "s" might possess many of the properties of the ether; while at one time suggested that the s emitted by radioactive substances consisted of small neutral particles, which, on breaking up, released a negative electron. The first suggestion of a neutral particle with the properties of the neutron we now know, was made by Rutherford in 1920. He thought that a proton and an electron might unite in a much more intimate way than they do in the hydrogen atom, and so form a particle of no nett charge and with a mass nearly the same as that of the hydrogen atom. His view was that with such a particle as the first step in the formation of atomic nuclei from the two elementary units in the structure of matter — the proton and the electron — it would be much easier to picture how heavy complex nuclei can be gradually built up from the simpler ones. He pointed out that this neutral particle would have peculiar and interesting properties."

"It has been shown by and others that when bombarded by s of emits a radiation of great penetrating power, which has an absorption coefficient in lead of about 0.3 (cm.)–1. Recently and found, when measuring the ionisation produced by this beryllium radiation in a vessel with a thin window, that the ionisation increased when matter containing hydrogen was placed in front of the window. The effect appeared to be due to the ejection of protons with velocities up to a maximum of nearly 3 × 109 cm. per sec. They suggested that the transference of energy to the proton was by a process similar to the , and estimated that the beryllium radiation had a quantum energy of 50 × 106 s."

"No physicist could tolerate religious dogma or extremism, but I have found that Christianity provides answers to the deeper questions about life and purpose which are beyond the range of science to answer. To me it is nonsense to claim, as some atheists do, that there is nothing worth knowing that is beyond the range of science. Religion is unfashionable in our current materialistic and consumer society, but I have not found Nobel Laureates to be especially atheistic. Accurate statistics are not available, and atheists tend to make more noise, but I know at least 6 examples amongst living physics laureates who are Christians. Being religious means accepting mystery, but so does physics. Things like quantum entanglement, where I can do something to an electron in the lab, and another electron at the edge of the Universe will respond instantly, are not understandable."

"For these early results in Xenopus to be reproduced in mammals took nearly 40 years (Campbell et al. 1996; Wilmut et al. 1997) in sheep. A very important feature of these first successful mammalian nuclear transfer in sheep was the use of unfertilised eggs, as was actually used in amphibia. Earlier work with mice (McGrath and Solter 1984) used fertilised eggs. Although fertilised eggs can be used (Egli et al. 2007), synchronisation between nucleus and egg is harder to achieve than with the use of unfertilised eggs. A very elegant and important experiment that confirmed the general principle that cell differentiation proceeds with the retention of a complete set of genes was carried out using nuclei with a rearranged genome from mature mouse B or T donor cells (Hochedlinger and Jaenisch 2002). In the course of time, somatic cell nuclear transfer to eggs has been successful in the eggs of mice and other mammals (Wakayama et al. 1998). In each species there seem to be some technical requirements which have to be identified and overcome."

"Gurdon's (1962) nuclear transplantation experiments showed that genes were neither lost nor permanently inactivated during development. Upon transfer of an intestinal cell nucleus into an enucleated egg, entire swimming tadpoles developed. However, the frequency of this event was low, unless nuclei were first injected into oocytes (DiBerardino et al., 1986), a step that might allow reprogramming by stripping the DNA of mitotically heritable regulatory influences. Thus, although these experiments provided strong evidence that differentiation was reversible, they did not determine whether genes were silenced by active or passive mechanisms in the course of development."

"Michail Fischberg was well aware of the value of genetics in developmental biology, and when I joined him, he had just started using Xenopus as a laboratory animal, on the grounds that it could be grown to sexual maturity within a year and that, as it is wholly aquatic, it is easy to keep in the laboratory. Xenopus can deliver eggs throughout the year, in contrast to the limited-season availability of eggs from Rana and European newts, the organisms of choice for European embryologists. The history of how a frog that naturally occurs only in Africa has come to be one of the half-dozen most used animals for research is bizarre (Gurdon & Hopwood 2000)."

"My own view of development is that one has to try to narrow things down to single entities, whether it's a cell or a nucleus or a molecule, and I'm often ridiculed because I always ask people what concentration their molecule is at, and they'll say that it doesn't matter. I'd say that concentration and time are the two critical things in development. You need to know the concentration, and you need to know how long it has to be there to make a difference – because for cells, a particular concentration of a molecule for a few seconds may not be the same as that concentration for 10 minutes. So I would take the view that what we really lack in developmental biology at the moment is any ability to determine the concentration of proteins, analogous to the measurement of nucleic acids using PCR."

"Cells specialise in ways determined by the concentration of signal that they receive ... The best example of signaling between cells is by the signal molecule activin, discovered in embryos by Makoto Asashima and J. C. Smith."

"In many materials the electrical behavior changes from metallic to nonmetallic when the pressure, temperature or magnetic field is varied or (as in alloys) when the composition is varied, and the theoretical description of these processes is quite complicated. The interest of the problem lies perhaps mainly in our imperfect understanding of the nature of a metal. In the days before quantum mechanics, when I first attended undergraduate lectures on the electron theory of solids, it was taught that in metals one or more atoms from each electron were free, whereas in nonmetals they were somehow fixed to the atoms or ions or to the chemical bonds. The long mean free paths of electrons in metals extending over hundreds or thousands of atomic spacings were not understood, and neither was the absence of any large contribution from the electrons to the specific heat."

"... in terms of modern solid state physics, what does “transparent” mean? It means that, in the energy spectrum of the electrons in the material, there is a gap of forbidden energies between the occupied states (the valence band) and the empty states (the conduction band); light quanta corresponding to a visible wave-length do not have the energy needed to make electrons jump across it. This gap is quite a sophisticated concept, entirely dependent on quantum mechanics, and introduced for solids in the 1930’s by the pioneering work of Bloch, Peierls and A. H. Wilson. The theory was based on the assumption that the material was crystalline. ... my coworkers and I ... asked the question "how can glass be transparent?"."

"The hypothesis that the electron has a magnetic moment was, as is well known, first introduced to account for the duplexity phenomena of atomic spectra. More recently, however, Dirac has succeeded in accounting for these same phenomena by the introduction of a modified wave equation, which conforms both to the principle of relativity and to the general transformation theory. Formally, at least, on the new theory also, the electron has a magnetic moment of εh/mc, but when the electron is in an atom we cannot observe this magnetic moment directly; we can only observe the moment of the whole atom, or, of course, the splitting of the spectral lines, which we may say is “caused” by this moment."

"Any scientist, myself or another, can become so enamoured of his brain child that he resents criticism."

"I do not believe that the present flowering of science is due in the least to a real appreciation of the beauty and intellectual discipline of the subject. It is due simply to the fact that power, wealth and prestige can only be obtained by the correct application of science."

"Molecules that differ from each other by rotation about single bonds are called conformational isomers or conformers. Derek H. R. Barton (…) showed that the chemical and physical properties of complicated molecules can be interpreted in terms of their specific or preferred rotational arrangements and that a knowledge of the conformations of molecules is crucial to understanding the stereochemical basis of many reaction."

"The natural sciences are sometimes said to have no concern with values, nor to seek morality and goodness, and therefore belong to an inferior order of things. Counter-claims are made that they are the only living and dynamic studies... Both contentions are wrong. Language, Literature and Philosophy express, reflect and contemplate the world. But it is a world in which men will never be content to stay at rest, and so these disciplines cannot be cut off from the great searching into the nature of things without being deprived of life-blood."

"In the last few years there has been a harvest of books and lectures about the "Mysterious Universe." The inconceivable magnitudes with which astronomy deals produce a sense of awe which lends itself to a poetic and philosophical treatment. "When I consider thy heavens, the work of thy hands, the moon and the starts, whuch thou hast ordained: what is man that thou art mindful of him? The literary skill with which this branch of science has been exploited compels one's admiration, but also, a little, one's sense of the ridiculous. For other facts than those of astronomy, oother disciplines than of mathematics, can produce the same lively feelings of awe and reverence: the extraordinary finenness of their adjustments to the world outside: the amazing faculties of the human mind, of which we know neither whence it comes not whither it goes. In some fortunate people this reverence is produced by the natural bauty of a landscape, by the majesty of an ancient building, by the heroism of a rescue party, by poetry, or by music. God is doubtless a Mathematician, but he is also a Physiologist, an Engineer, a Mother, an Architect, a Coal Miner, a Poet, and a Gardener. Each of us views things in his own peculiar war, each clothes the Creator in a manner which fits into his own scheme. My God, for instance, among his other professions, is an Inventor: I picture him inventing water, carbon dioxide, and haemoglobin, crabs, frogs, and cuttle fish, whales and filterpassing organisms ( in the ratio of 100,000,000,000,000,000,000,000 to 1 in size), and rejoicing greatly over these weird and ingenious things, just as I rejoice greatly over some simple bit of apparatus. But I would nor urge that God is only an Inventor: for inventors are apt, as those who know them realize, to be very dull dogs. Indeed, I should be inclined rather to imagine God to be like a University, with all its teachers and professors together: not omittin the students, for he obviously possesses, judging from his inventions, that noblest human characteristic, a sense of humour."

"To suppose that chemistry and poetry are incompatible (as I am sure Prof Donnan would not do!), or that biology is inconsistent with a religious outlook on the world (I don not say with theology!) is to misunderstand entirely what the human mind, by contemplation and experiment, has achieved. By extreme specialization at intervals, by overloading the machine to its limit, discoveries and progress are made: but their bearing is best seen by letting the engine idle and giving oneself time to look around. The chemist and the poet are both right, the biologist and the saint: and each must pull up now and then to find whither he is going and to adjust his spectacles."

"All knowledge, not only that of the natural world, can be used for evil as well as good: and in all ages there continue to be people who think that its fruit should be forbidden. Does the future wlfare, therefore, of mankind depend of a refusal of science and a more intensive study of the Sermon on the Mount? There are others who hold the contray opinion, that more and more of science and its applications alone can bring prosperity and happiness to men. Both of these extremes views seem to me entirely wrong - though the second is the more perilous as more likely to be commonly accepted. The so-called conflict between science and religion is usually about words, too often the words of their unbalanced advocates: the reality lies somewhere in between. "Completeness and dignity", to use Tyndall's phrase, are brought to man by three main channels, first by the religiouos sentiment and its embodiment of ethical principles, secondly by the influence of what is beautiful in nature, human personality, or art, and thirdly, by the pursuit of scientific truth and its resolute use in improving human life. Some suppose that religion and beauty are incompatible: others, that the aesthetic has no relation to the scientific sense: both seem to me just as mistaken as those who hold that the scientific and the religious spirit are necessarily opposed. Co-operation is required, not conflict: for science can be used to express and apply the principles of ethics, and those principles themselves can guide the behaviour of scientific men: while the appreciation of what is good and beautiful can provide to both a vision of encouragement. Is there really then any special ethical dilemma which we scientific men, as distinct from other people, have to meet? I think not: unless it be to convince ourselves humbly that we are just like others in having moral issues to face. It is true that integrity of thought is the absolute condition of oour work, and that judgments of value must never be allowed to deflect our judgements of fact. But in this we are not unique. It is true that scientific research has opened up the possibility of unprecedented good, or unlimited harm, for manking: but the use is made of it depends in the end on the moral judgments of the whole community of men. It is totally impossible noew to reverse the process of discovery: it will certainly go on. To help to guide its use aright is not a scientific dilemma, but the honourable and compelling duty of a good citizen."

"[The same transactions are not always] entered in the same category for receiving and paying country."

"The great majority of politicians and other interested persons tend to....concentrate on....measures such as education and training of labour and investment in modern efficient capital equipment....These reforms are of extreme importance but they are concerned basically with raising the output per head of those who are in employment rather than about the number of heads that will find suitable employment."

"By a ‘spontaneous disturbance’ we shall mean any change in the underlying conditions, the cause of which we are prepared to take for granted and do not wish to examine, but the effect of which on the domestic and external position of our two countries we wish to examine. By a ‘policy’ change we shall mean a change which the State or some public authority brings about as a result of a definite decision of State policy in order to achieve some given end of general economic policy and in particular to offset some of the effects of a ‘spontaneous disturbance’. Finally, by an ‘induced’ change is meant a change in some quantity which occurs on purely commercial principles because of the repercussions of some previous ‘spontaneous’ or ‘policy’ change."

"Stone was by no means the first economist to produce national income accounts. Simon Kuznets, for example, had already done so for the United States. Stone’s distinctive contribution was to integrate national income into a double-entry bookkeeping format. Every income item on one side of the balance sheet had to be matched by an expenditure item on the other side, thus ensuring consistency. Stone’s double-entry method has become the universally accepted way to measure national income."

"[Central banks might have to intervene to counter "perverse" or "grossly excessive" speculation.] By such means, the monetary authorities can attempt to make the market for foreign exchange approximate toward what it would have been if there had been free competitive speculation with correct foresight of future movements. In this case all that the authorities have to do is to anticipate more correctly than private speculators the future course of exchange rates. And in so far as they do so they will make a profit at the expense of the private speculator."

"The usefulness of observation and measurement in testing economic theories arises because the theorems of economics are supposed to relate to the actual world... Any economic theorem rigorously deduced from given postulates may be regarded as a hypothesis about the actual world which xperience may show to be false."

"We shall talk as if the objective of internal balance were simply that of maintaining a level of total demand for all the country’s products sufficiently high to maintain full employment, but not so high as to lead to a continuing inflation of money prices and costs."

"The usefulness and importance of a system of national accounts can most readily be appreciated by returning to origins of the method and at the same time considering the actual necessity of this type of analysis. This new analytical technique was first introduced in Great Britain during the Second War. John Maynard Keynes was at that time an expert adviser to the Treasury on problems of war finance, and his assistants included Richard Stone. Keynes took as his starting point a balance between total current resources (including real gross national product) on the supply side and total consumption, investments and expenditure for the war effort on the demand side. Richard Stone's experiments in the systematic processing of the copious flood of statistical material in the form of national accounts moved Keynes to exclaim: "We are in a new era of joy through statistics". Stone's ideas on the design of national accounts were from the beginning aimed at full integration of national accounts for the various sub-sectors which between them represented the entire national management of resources. Every item of income and expenditure on one side of an account must recur as the opposite item - expenditure and income respectively - in another account. An integral system of accounts included, for example, household income and expenditure, the expenditure and revenues of the enterprise sector (expenditure, for example, including wage payments), national saving and investment, public sector spending and revenues and, finally, balances of payments vis-à-vis other countries. This double-entry accounting provided opportunities of cross-checking statistics for the numerous transactions. Figures from different sources had to tally."

"The object of this paper is fivefold. The first objective is to derive a practical system of demand equations which possess properties usually considered desirable from the standpoint of elementary economic theory. The second is to consider the statistical problems involved in applying the system of equations. The third is to analyse the pattern of demand for consumers' goods in terms of this system on the basis of annual data relating to the United Kingdom over the years 1920-38. The fourth is to compare the results of this system, and systems like it, with the actual state of demand in 1900. Finally, the fifth is to compare the post-war structure of demand with what might be expected from the inter-war relationshipp under free-market condition."

"We usually find a considerable degree of correlation between indicators and also between different sets of weights that we should ever think of using. Consequently we are likely to find that alternative index numbers using different weights show similar and often approximately proportionate movements. That this is so in most economic applications is due to the nature of the actual world and not simply to the formal characteristics of index number techniques."

"Econometrics may be defined as the quantitative analysis of actual economic phenomena based on the concurrent development of theory and observation, related by appropriate methods of inference."

"He was lucky enough to rub shoulders with a fellow student, Mr. W T. Newlyn, now lecturing on money at the University of Leeds, who was less of an engineer but more of a monetary theorist than himself. Together they discussed how monetary theory could be represented by an hydraulic model."

"In the first place, economic theory provides a comparatively detailed specification of the demand relationships for individual consumers' goods, but is by no means so specific about the system into which these relationships fit. It would be possible to close the system in very many ways, and the precise way selected would influence the regression estimates in a model involving simultaneous equations."

"In the second place, a system would involve more variables than those which may be supposed to enter into demand relationships, and so the preliminary work of estimating the necessary time series would also be increased. In the third place, in the simultaneous method of estimation the estimates of the original parameters come to depend on most of the remaining estimates, and so it is quite likely that they will have large sampling variances."

"The frontiers of knowledge in the various fields of our subject are expanding at such a rate that, work as hard as one can, one finds oneself further and further away from an understanding of the whole."

"A choice may have to be made between a biased estimator which is believed to be relatively accurate and an unbiased estimator which is demonstrably highly inefficient, and it is by no means obvious that the latter is always to be preferred."

"From 1931 to 1935, I was an undergraduate at Cambridge in my father's old college, Gonville and Caius, which was particularly strong in medicine and the law. However, after two years of law I switched to economics, much to my father's disappointment. At that time the world was in the depth of the great depression and my motive for wanting to change subject was the belief, bred of youthful ignorance and optimism, that if only economics were better understood, the world would be a better place."

"The last of the utilitarians who trace from Jeremy Bentham, James Meade would give his cloak to a shivering beggar, not only because he feels it is right and fair to do so, but also for the reason that the beggar will receive more pleasure from it than a well-off professor of political economy."

"Any one country can be in any of four possible disequilibrium situations. It can be (1) a surplus country with a domestic slump, (2) a surplus country with a domestic boom, (3) a deficit country with a domestic slump, or (4) a deficit country with a domestic boom."

"On principle i relative prices will be lowered in the interests of external balance and domestic expenditure will be inflated in the interests of internal balance. Internal balance will be very quickly restored although there is no net change in external balance. Relative prices must, therefore, continue to be lowered, which will tend now to produce a boom at home. The inflationary financial policy must, therefore, be replaced by a deflationary policy. In the end relative prices will be substantially lowered, while there may be a small net inflation or deflation of domestic expenditure by financial policy."

"I have tried to make clear in this brief sketch of the nature of deductively formulated theories, at least as they occur in economics, that, although their origin lies in common observation and introspection, nevertheless they are capable of a purely mathematical development through the exact statement of a of a set of postulates which, however, since they must inevitably contain assumptions about human behaviour, require to be tested by reference to actual events."

"Now there are two ways in which the authorities of a particular country may combine the use of financial policy and of price adjustment. (i) First, financial policy may be used for the preservation of internal balance and price adjustment for the preservation of external balance. (ii) Second, financial policy may be used for the preservation of external balance and price adjustment for the preservation of internal balance. On either of these principles the authorities of any one country can set about the simultaneous preservation of internal and external balance."

"It is a special privilege for me on this occasion to have my name associated with that of Professor Bertil Ohlin. By the younger generation of economists we are no doubt both regarded as what in my country are now known as 'senior citizens'; but I am just that much younger than Professor Ohlin to have regarded him as one of the already established figures when I was first trying to understand international economics. His great work on International and Interregional Trade opened up new insights into the complex of relationships between factor supplies, costs of movement of products and factors, price relationships, and the actual international trade in products, migration of persons, and flows of capital. Of the two volumes which I later wrote on International Economic Policy - namely, The Balance of Payments and Trade and Welfare - it is in the latter that the influence of this work by Professor Ohlin is most clearly marked."

"My interest in economics had the following roots. Like many of my generation I considered the heavy unemployment in the United Kingdom in the inter-war period as both stupid and wicked. Moreover, I knew the cure for this evil, because I had become a disciple of the monetary crank, Major , to whose works I had been introduced by a much loved but somewhat eccentric maiden aunt. But my shift to the serious study of economics gradually weakened my belief in Major Douglas's A+B theorem, which was replaced in my thought by the expression MV = PT."

"In 1945, the war ended and I was chosen to be the first director of the newly-established Department of Applied Economics in Cambridge. Between leaving the government service and taking up my new post, I had a break of about three months which I spent at the Institute of Advanced Study in Princeton. I intended to use my time there writing up my ideas on a social accounting system for the measurement of economic flows, a thing I had wanted to do for years but had not had time for during the war. What happened was that, in Princeton, I met , the Director of Intelligence at the League of Nations, who wanted a paper on the problems of defining and measuring the national income and related totals for consideration by the League's Committee of Statistical Experts. He asked me if I would undertake the work and naturally I accepted. I soon had a memorandum ready and it was discussed in Princeton while I was still there by a subcommittee convened by Loveday. Their report was eventually published by the United Nations in Geneva in 1947 under the title, Measurement of National Income and the Construction of Social Accounts, with my memorandum as an appendix."

"A good book on the subject of the customs union has for long been wanted; and now it is provided by Professor Viner's study, which it is difficult to praise too highly.... Professor Viner's study on the economic aspects of customs unions will be of central interest to economists. Indeed for many years this is likely to remain the locus classicus for the economic analysis of customs-union problems."

"We assume...that the banking system must be prepared to expand (or contract) the total supply of money to the extent necessary to prevent any scarcity (or plenty) of funds in the capital market which may be induced by any other disturbing factor, from causing a rise (or fall) in interest rates"

"There is no hope, as far as I can see, of pushing the postulates of economic theory back to a set of irreducible axioms."

"Professor Ohlin also made an important contribution to what now might be called the macro-economic aspects of a country's balance of payments. In 1929 in the Economic Journal he engaged in a famous controversy with Keynes on the problem of transferring payments from one country to another across the foreign exchanges. In this he laid stress upon the income-expenditure effects of the reduced spending power in the paying country and of the increased spending power in the recipient country. In doing so he made use of the usual distinction between a country's imports and exports; but in addition he emphasised the importance of the less usual distinction between a country's domestic non-tradeable goods and services and its tradeable, exportable and importable, goods. I made some use of this latter distinction in my Balance of Payments; but looking back I regret that I did not let it play a much more central role in that book"

"Sir John Hicks (1904–89) was a leading economic theorist of the twentieth century, and along with Kenneth Arrow was awarded the Nobel Prize in 1972. His work addressed central topics in economic theory, such as value, money, capital, and growth. An important unifying theme was the attention to economic rationality ‘in time’ and his acknowledgment that apparent rigidities and frictions might exert a positive role as a buffer against excessive fluctuations in output, prices, and employment. This emphasis on the virtue of imperfection significantly distances Hicksian economics from both the Keynesian and monetarist approaches."

"So long as we confine our attention to income from property, and leave out of account any increment or decrement in the value of prospects due to changes in people's own earning power (accumulation or decumulation of “Human Capital”), Income No. 1 ex post is not a subjective affair, like other kinds of income; it is almost completely objective."

"The British economist John Hicks is known for four contributions. The first is his introduction of the idea of the elasticity of substitution... His second major contribution is his invention of what is called the , a graphical depiction of the argument John Maynard Keynes gave in his ' (1936) about how an economy could be in equilibrium with less than full employment... Hicks’s third major contribution is his 1939 book ', in which he showed that most of what economists then understood and believed about value theory (the theory about why goods have value) can be derived without having to assume that utility is measurable... Hicks’s fourth contribution is the idea of the compensation test."