"We learned that a virus freshly isolated from man or animal did not necessarily behave like the virus strain that we maintained in the laboratory, so-called tame virus, which might have been passaged through animals or tissue culture for generations. Virologists had to recognize that by transmission of a virus from animal to animal or from culture to culture over a period of time, what we ended up with through a process of natural selection or genetic selection was a virus adapted to growth in a new environment. A population of viruses is no more homogeneous than the human population; by passage, one culls out all of the inhomogeneous particles and leaves behind those which survive and grow so well,"
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Edwin H. Lennette, "Pioneer of Diagnostic Virology with the California Department of Public Health, an oral history conducted in 1982, 1983, and 1986 by Sally Hughes, Regional Oral History Office, The Bancroft Library, University of California, Berkeley, 1988, p. 125
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