"Recent work with real-time fMRI, in conjunction with compatible EEG/MEG, shows promise in allowing us to observe the brain at work (or play). Perhaps this method, in conjunction with effective connectivity data analysis techniques, will permit us to unravel the continuing mysteries of the orgasm sequence. How the various brain regions influence each other, activating and inhibiting one another, to produce the pleasures leading up to and including orgasm may well have applications beyond the bedroom. This method has already been therapeutically applied as a tool for neuro biofeedback, with the goal to increase activity in the left amygdala (Zotev et al., 2014) and insula (Veit et al., 2012), which has been associated with enhanced mood regulation and reduced symptoms of anxiety and depression. It is possible that by studying people who are virtuosos in regulation of their pleasure systems, such as the easily orgasmic women in our study who activated their genital sensory cortex simply by “imagining” genital stimulation, or the population of women who can literally “think” themselves into orgasm, previously studied by our group(Whipple et al, 1992), we will learn more effective strategies for helping mood-challenged individuals exercise the brain’s capacity for self-regulation."