"As predicted, the results showed clear evidence that many brain regions were differentially activated during the course of genital stimulation leading up to and culminating in orgasm in these women. These activations include sensory, motor, reward, frontal cortical and brainstem regions, i.e., the genital sensory cortex (paracentral lobule), secondary somatosensory cortex (operculum SII, regions OP1 and OP4), precuneus, inferior parietal lobule, insula, hippocampus, amygdala, cerebellum, supplementary motor area, dorsal and ventral striatum (caudate, putamen, and nucleus accumbens), substantia nigra, the mesolimbic dopamine system (ventral tegmentum), hypothalamus, pons, anterior and posterior cingulate cortex, temporal pole, and the prefrontal cortex."