"Man, not contented with the Liquors, which his bountiful Creator intending for his Comfort, has wisely tempered with such a due Proportion of Strength, as would (if taken in Moderation,) make his Heart glad, has unhappily found Means to extract, from what God provided for his Refreshment, a most intoxicating and baneful Spirit, to which, in a great measure, is owing the remarkable Increase of Drunkenness of late Years; which Vice reigns to a most enormous Degree, among the habitual Drinkers of Gin, Brandy, and other Distilled Liquors; which are found to be most pernicious and destructive. For at the same shat they coagulate and thicken the Blood, they also contract and narrow the Blood-Vesels; which has, in fact, been found to be true, by Experiments I have purposely made with Brandy, on the Blood and Blood-Vesels of Animals."