"As a way of living, ataraxia is an illusion. Epicureans try to simplify their life so as to reduce to a minimum the pleasures they can lose. But they cannot secure their tranquil garden against the turmoil of history. The Stoic sage insists that while we cannot control the events that happen to us, we can control how we think about them. But this is so only within a narrow margin. A fever, a tsetse fly or a traumatic experience can unsettle the mind at a crucial moment, or for ever. Disciples of Pyrrho try to establish inner equilibrium by a suspension of judgement. But sceptical doubt cannot banish the unrest that comes with being a human being. Even if ataraxia could be achieved, it would be a listless way to live. Luckily, deathly calm is not in practice a state that humans can maintain for very long. All these philosophies have a common failing. They imagine life can be ordered by human reason. Either the mind can devise a way of life that is secure from loss, or else it can control the emotions so that it can withstand any loss. In fact, neither how we live nor the emotions we feel can be controlled in this way. Our lives are shaped by chance and our emotions by the body. Much of human life – and much of philosophy – is an attempt to divert ourselves from this fact."
January 1, 1970
https://en.wikiquote.org/wiki/Philosophical_pessimism