"3. Premature and effective development is a symptom closely allied to the two preceding. When it cannot be traced to such natural causes as overstudy, overwork, lack of exercise, and other influences of a similar nature, it should be charged to self-abuse. The early exercise of the genital organs hastens the attainment of puberty, in many cases, especially when the habit is acquired early, but at the same time saps the vital energies to that the system is unable to manifest that increased energy in growth and development which usually occurs at this period. In consequence, the body remains small, or does not attain that development which is otherwise would. The mind is dwarfed as well as the body. Sometimes the mind suffers more than the body in lack of development, and sometimes the reverse is true. This defective development is shown, in the physical organization of males, in the failure of the voice to increase in volume and depth of tone as it should; in deficient growth of the beard ; in failure of the chest to become full and shoulders broad. The mind and character show the dwarfing influence by failure to develop show the dwarfing influence by failure to develop those qualities which especially distinguish early womanhood. Such signs deserve careful investigation, for they can only result from some powerfully blighting influence."