"The two letters to Wallis in which Newton] explained his method of fluxions and fluents were written in 1692, and were published in 1693. Towards the close of 1692 and throughout the two following years Newton had a long illness, suffering from insomnia and general nervous irritability. He never quite regained his elasticity of mind, and though after his recovery he shewed the same power in solving any question propounded to him, he ceased thenceforward to do original work on his own initiative, and it was difficult to stir him to activity."
January 1, 1970
https://en.wikiquote.org/wiki/History_of_calculus