"In the first two thirds of the seventeenth century mathematicians solved calculus-type problems, but they lacked a general framework in which to place them. This was provided by Newton and Leibniz. Specifically, they a. invented the general concepts of and —though not in the form we see them today... b. recognized differentiation and integration an inverse operations. Although several mathematicians... noted the relation... in specific cases... the clear and explicit recognition, in its complete generality, of... the belongs to Newton and Leibniz. c. devised a notation and developed algorithms to make calculus a powerful computational instrument. d. extended the range and applicability of the methods... While in the past those methods were applied mainly to polynomials, often of low degree, they were now applicable to "all" functions, algebraic and transcendental."