"Evaluating the potential threat posed by advances in biotechnology, especially genetically modified organisms (GMOs), and synthetic biology remains a contentious issue. The rapid development of the tools of molecular biology and metabolic engineering has enabled the development of chimeric organisms which possess characteristics which are not native to the wild variant. This is commonplace in the area of biomanufacturing, where genes are introduced into organisms such as E coli and products manufactured via large-scale fermentation. More recently, entire metabolic pathways, albeit of limited complexity, have been engineered into organisms, for example, for the production of artemisinin in yeast. In addition to such metabolic engineering projects, whole genomes are being sequenced, leading to the possibility of creating organisms de novo. Numerous lectures, briefings and articles have argued that the dual use nature of biotechnology, the training of foreign students in American universities, and the easy availability of information on the internet have given potential adversaries access to biological weapons of unimagined which pose an existential threat. Some believe that, inevitably, these advances will lead to a catastrophic biological attack. Others have argued the opposite that making all information publicly available will enable a more universal “white biotechnology” which will ultimately monitor the field and provide the means to defeat any threat developed by adversaries. It has been argued that, despite these advances, the scientific and technical requirements, as well as the fundamental laws of natural selection, will prevent such an attack."