"Anticipations of Cardan are more truly wonderful when we consider that the symbolical language of algebra, that powerful instrument not only expediting the processes of thought, but in suggesting general truths to the mind, was nearly unknown in his age. Diophantus, Fra Luca, and Cardan make use occasionally of letters to express indefinite quantities besides the res or cosa, sometimes written shortly, for the assumed unknown number of an equation. But letters were not yet substituted for known quantities. Michael Stifel, in his Arithmetics Integra, Nuremberg, 1544, is said to have first used the signs + and -, and numeral exponents of powers. It is very singular that discoveries of the greatest convenience, and apparently, not above the ingenuity of a village schoolmaster, should have been overlooked by men of extraordinary acuteness like Tartaglia, Cardan, and Ferrari; and hardly less so, that by dint of this acuteness they dispensed with the aid of these contrivances, in which we suppose that so much of the utility of algebraic expression consists."