"I have raised a question which may be regarded as heretical. At the time when our modern conception of chemistry first dawned... the average chemist... accepted the elements as ultimate facts... absolutely simple, incapable of transmutation or decomposition, each a kind of barrier behind which we could not penetrate. ...[H]e said they were self-existent from all eternity ...But in our times... we cannot help asking what are the elements, whence do they come, what is their signification? ...These elements perplex us in our researches, baffle us in our speculations, and haunt us in our very dreams. They stretch like an unknown sea before us—mocking, mystifying and murmuring strange revelations and possibilities. If I venture to say that... elements are not simple and primordial... but have evolved from simpler matters—or... one sole kind of matter—I... give formal utterance to an idea... for some time "in the air" of science. Chemists, physicists, philosophers of the highest merit declare explicitly their belief that the seventy... elements of our text-books are not the which we must never hope to pass."