"The newly defined mesenchymal-like stem cells from MB called MenSCs are a new source of stem cells with good proliferation rate and capability in differentiation into various cell types similar to many other kinds of adult stem cells. Kazemnejad et al. investigated hepatic differentiation capacity of MenSCs compared to mesenchymal stem cells derived from bone marrow. The derivation of adipogenic lineage, glial cells, and cardiogenic lineage were also demonstrated in other studies. In addition, these easily accessible adult stem cells have the capacity to trans-differentiate into neuronal cells, pancreatic cells, and osteocytes. These investigations suggest this new source as a safe alternative to other adult stem cells for cell therapies in different diseases. So we concluded the MenSCs could provide a suitable cell sources in repair and regenerate of skin diseases and naturally photoaging of skin. We are on the line to develop and suggest the standard inducing media and protocols to derive epidermal lineage from MenSCs. By achieving this goal, novel cell-based therapies will be proposed to use in many experimental and clinical studies."