"In order to achieve the end goal of the use of MenSCs in clinical implementation, the standard criterion of sample collections is needed to produce high quality and high consistency of MenSCs; more importantly, fundamental pre-clinical research is demanded for establishing more treatment strategies and exploring precise signaling pathways. Finally, the long-term safety of MenSCs should be assessed before they are used in clinical medicine. In summary, although more work needs to be done, MenSCs have been proved to play multi-functional roles in treating a variety of diseases through diversely therapeutic strategies in preclinical research, which will be contributed to the development of MenSC-based treatment in regenerative medicine and clinical applications."