"Unique events are unrepeatable and cannot be subjected to any sort of experimental investigation. … His general theory, that all life on earth had originated and evolved by a gradual successive accumulation of fortuitous mutations, is still, as it was in Darwin’s time, a highly speculative hypothesis entirely without direct factual support and very far from that self-evident axiom some of its more aggressive advocates would have us believe."
January 1, 1970
https://en.wikiquote.org/wiki/Mutant