"The overall yield in a multistep step synthesis is the product of the yields for each separate step. In a linear synthetic scheme, the hypothetical TM is assembled in a stepwise manner. … Since the overall yield of the TM decreases as the number of individual steps increases, a convergent synthesis should be considered in which two or more fragments of the TM are prepared separately and then joined at the latest-possible stage of the synthesis. It should be noted, however, that the simple overall yield calculation is some- what misleading since it is computed on one starting material, whereas several are used and the number of reactions is the same! Nevertheless, the increased efficiency of a convergent synthesis compared to the linear approach is derived from the fact that the preparation of a certain amount of a product can be carried out on a smaller scale."