"Not that I at all disallow the use of reasoning upon experiments, or the endeavouring to discern as early as we can the confederations, and differences, and tendencies of things: for such an absolute suspension of the exercise of reasoning were exceeding troublesome, if not impossible. And, as in that rule of arithmetic, which is commonly called ' by proceeding upon a conjecturally-supposed number, as if it were that, which we inquire after, we are wont to come to the knowledge of the true number sought for; so in physiology it is sometimes conducive to the discovery of truth, to permit the understanding to make an hypothesis, in order to the explication of this or that difficulty, that by examining how far the phænomena are, or are not, capable of being solved by that hypothesis, the understanding may, even by its own errors, be instructed."