"[John P.] Bull... wrote his history of the clinical trial in 1951. He argued that the conduct of "clinical trials" can be traced to the ancient Egyptians. ...Highlighting historic events—such as Avicenna's rules for testing drugs, Francis Bacon's suggestion of a committee of physicians to judge therapeutic efficacy, James Lind's comparative trial of scurvy "cures", and P.C.A. Louis's application of his numerical method in the clinic—Bull presents a linear account of the development of the clinical trial. The implication... is that, cumulatively, these historic experiments made the clinical trial progressively more scientific."
January 1, 1970
https://en.wikiquote.org/wiki/Pierre_Charles_Alexandre_Louis