"The biggest single obstacle to the full use of mathematics in real neuroscience is the sheer difficulty of the relevant mathematics. The brain is far more complex than today's computers; therefore to understand it, one must use even more sophisticated mathematics than the average research engineer is familiar with. Because of this difficulty, a few "middle men" have presented oversimplified description of biology to the engineers, and oversimplified descriptions of the engineering to the biologists. These oversimplifications have often led to considerable misunderstanding and justified mistrust."