"One of the issues that John von Neumann and McCulloch discussed was reliability in the brain. One version of the story was that McCulloch got a 3:00 AM phone call from von Neumann to say, “I have just finished a bottle of creme de menthe. The thresholds of all my neurons are shot to hell. How is it I can still think?” (In other versions of the story, von Neumann was called by McCulloch, and the drink was whisky.)"