"Just as a physician might say there isn’t a single human being who enjoys perfect health, so someone with a proper knowledge of man might say there is not a single human being who does not despair at least a little, in whose innermost being there does not dwell an uneasiness, an unquiet, a discordance, an anxiety about a possibility in life or an anxiety about himself, so that as a physician speaks of one’s going about with an illness in the body, he goes about with a sickness, goes about weighed down with a sickness of the spirit, which only now and then reveals its presence within, in glimpses, and with what is for him an inexplicable anxiety."
January 1, 1970
https://en.wikiquote.org/wiki/Despair