"It is clear from studies FDA reviewed on animal health that clones have higher rates of illness and death than non-clone comparators, particularly at the younger ages. This could lead to greater use of drugs on clones, which in turn could exacerbate antibiotic resistance. FDA’s Risk Assessment failed to assess this risk. In both cloned cattle and sheep, one of the biggest health problems is large offspring syndrome (LOS). As the name implies, LOS refers to offspring that are abnormally large at birth, but they also have a range of other abnormalities. FDA lists 11 clinical signs associated with LOS, including fetus weight more than 20% larger than average for the breed, deformities of limb and/or head, disproportionate or immature organ development, increased susceptibility to infection, and cardio vascular problems. Since cattle with LOS tend to have increased susceptibility to infection, there would be a greater need for antibiotics and other drugs to help fight the infections in those LOS cattle. Although LOS doesn’t appear to happen normal reproduction or AI, it does happen with some of the ARTs, such as in-vitro fertilization (IVF), embryo culture, as well as with SCNTs"