"The Roman Catholic medical-ethical handbooks and compendia of moral theology that emerged at the end of the 19th century and enjoyed a flourishing in the 1950s have a continuity with Roman Catholic moral theological reflections, reaching to the beginning of the 16th century and to the flowering of Western scientific interest in medicine and its foundational sciences. From the 16th century onward, moral theological interest in medicine was driven by the remarkable medical progress after the Renaissance. Even Descartes (1596-1650) thought he could extend life, given the promise of medical knowledge. Medicine claimed importance before it could convey much benefit. Though therapeutic benefits came later, there were striking advances in knowledge. From Vesalius to Harvey to Morgagni through Bichat and Virchow and the explosion of medical science in the 19th century. New construals of research and science altered the very meaning of medical knowledge. In contrast, in the wake of the Council of Trent (1545-1563) there developed a continuity in Roman Catholic moral theological reflections that extended unbroken into the early 1960s. Roman Catholic moral thought had a previous substantial change in its character when it passed from the pre-Scholastic to the Scholastic period. The pre-Scholastic era, which was pastoral in its character, was much loser in its theological spirit to that o the Church of the first millennium. The Scholastic period, which began in the 12th century and extended to the Council of Trent, was marked by a concern with discursive rational reflection and systematization. The modern period, which began with Trent, in great measure carried forward the Scholastic tradition, but now more fully developed. It was in this period that reflections on medicine became the focus of whole works and began to constitute a sub-discipline of moral theology. This post-Tridentine, medical-ethical, moral theological literature was insightful. It constituted much more than merely wooden applications of past reflections. This significant body of Roman Catholic medical ethical reflection and scholarship was characterized by its constituting a single coherent community of research."