"The princes of the Italian Renaissance routinely used intrigue, treachery, and murder to further their aims. The most notorious among them were the Borgias, whose despotic rule of church and state made a lasting impression. Their leader, Pope Alexander VI, was a greedy and lecherous reprobate. His daughter Lucrezia gained an undeserved reputation for poisoning and incest, and her cold-blooded brother Cesare stopped at nothing to gain and increase power. Together, they terrorized Rome and expanded its domain. Their enterprise collapsed when Alexander Vi died, possibly by poisoning."