"Approximately 1 in 250 adults or almost 1 million adults in the United States identify as transgender. The frequency of adults, and especially younger adults, reporting a gender diverse identity has increased over time. Some persons who identify as transgender or gender-diverse (TGD) will seek treatment with gender-affirming hormones to align their bodies more closely with their gender identity. Medical treatment of people who identify as transgender improves body satisfaction, quality of life, and mental health. However, many of these treatments are not entirely reversible."