"Even the laws of thermodynamics... can be recast in terms of information — Shannon entropy, the laws of bits of information. But this view generates its own paradox at the origin of life. ...Place information at the heart of life, and there is a problem with the emergence of function ...the origin of biological information. There are problems... in understanding why we age and die... diseases... and how experiences can give rise to conscious mind. ...A far better question ...what processes animate cells and set them apart from inanimate matter?"
January 1, 1970
https://en.wikiquote.org/wiki/Thermodynamics