"Three technical aspects of thermonuclear weapons have made thermonuclear war a peril to the very existence of humanity. These aspects are: the enormous destructive power of a thermonuclear explosion, the relative cheapness of rocket-thermonuclear weapons, and the practical impossibility of an effective defense against a massive rocket-nuclear attack."
January 1, 1970
https://en.wikiquote.org/wiki/Andrei_Sakharov