"Physics represents the ultimate reductionist subject: Physicists reduce matter first to molecules, then to atoms, then to nuclei and electrons, and so on, the goal being always to reduce complexity to simplicity. The extraordinary success of that approach is based on the concept of an isolated system. Experiments carried out on systems isolated from external interference are designed to identify the essential causal elements underlying physical reality. The problem is that no real physical or biological system is truly isolated, physically or historically."