"We may in these processes obtain very great quantities of energy, but on the average we cannot hope to obtain energy for practical use in this way. The bombardment of the atom is a very poor and inefficient way of producing energy and anyone who is looking for a source of cheap power in the transformation of the atom, is talking pure moonshine... Some day the knowledge we may gain may be of practical value, but there is no indication of it yet."
January 1, 1970
https://en.wikiquote.org/wiki/Ernest_Rutherford