"[...] Desire, which, as Plato reminds us, is made up of “lack” and “nothingness”, demands that the dose be increased, so that in a certain sense drug addiction reproduces, like nothing else, the perfect functioning of desire, which does not seek pleasure in the world, but the rapid and immediate extinction of that “lack” which is its constitutive structure. In fact, no one desires what they have, but only what they do not have. “Nothingness is the soul of desire”, which, in its anaesthetic version, makes appetite irresistible and pleasure unsatisfactory. (p. 70)"
January 1, 1970
https://en.wikiquote.org/wiki/Umberto_Galimberti