"Laboratory instructions and recipes are sometimes edited into books with a wide circulation. Even in the late twentieth century, publications of this nature remained influential. For example, s from a 1980 summer course on at provided the basis for a bestselling laboratory manual by , and . Not only did the Molecular Cloning: A Laboratory Manual become a standard reference for s (commonly called the ‘bible’), but also its recipes and clear instructions made gene cloning and technologies accessible to non-specialists. Consequently, this laboratory manual contributed to the rapid spread of genetic-engineering techniques throughout the , as well as in industry. As is often the case with how-to books, however, finding a way to update methods in this rapidly changing field posed a challenge, and various molecular-biology reference books had different ways of dealing with knowledge obsolescence. This paper explores the origins of this manual, its publication history, its reception and its rivals – as well as the more recent migration of such laboratory manuals to the Internet."