"Born of pioneering stock, with three generations of physicians behind him, it is not surprising that should turn the full force of his tremendous energies to charting a little known field — the human brain. After attending Yale College and , he went to the where, under the influence of , Osler and , he made himself eminent as a and as a leader in the reform of . Cushing was one of the earliest in the United States to use s; the first to take routinely during surgical operations and in general practice. The use of the in brain operations was first developed by him."