"An example of how this is the best of times for evolutionary biology is provided by the recent elucidation of a draft sequence of all 3-billion-plus nucleotide pairs in the human genome et al. 2001, et al. 2001). ... Some prognosticators believe that the application of recombinant DNA methods to gene therapy and gene replacement (the repair or replacement of defective genes in the body) soon may lead to a revolution in the history of medicine comparable to the introductions of sanitation, anesthesia, and antibiotics and vaccines. If the new recombinant gene technologies live up to their early billing, we or our children might see a day when gene therapy can alleviate sickle cell anemia, heart disease, cancer, or various other human genetic disorders. Just as we may marvel at our forebears' fortitude in the dark ages before the advent of our modern medicine, our grandchildren may look back with marvel at our fortitude in the era preceding the wide availability of gene therapies. Nonetheless, the technical hurdles remain daunting. … … Ecologists and natural historians are painfully aware that the subject matter of their devotion—biodiversity—is under assault worldwide as the continents fill with people. The collective weight of human activities is leading to the disappearance of wilderness. Atmosphere and oceans are being polluted, marine fisheries are collapsing worldwide, and wetlands and freshwater aquifers have shrunk dramatically. In short, Earth's renewable and nonrenewable resources are being tragically squandered. In the Amazon Basin, for example, which is famous for its rich biota, slash-and-burn fires are so numerous that their light is visible to astronauts in the space shuttle. Some of these astronauts have felt moved to speak in a deeply spiritual tenor about the beauty of the “blue planet” and to bemoan how we are despoiling this special, fragile place."