"There is no need or purpose in trying to explain Mc 3,21 22 away. Both constituted a problem for Mt and Lc as they do for us. They solved the difficulty by omission or modification ; this we cannot do. We may urge critical considerations concerning Mc's theology of Jesus' person as incomprehensible and his method of presenting his theology. Historical reconstruction may find reasons for an estrangement between Jesus and his family. We know further that a man's enemies are seldom, if ever, reliable and impartial judges of his mental soundness. But we must admit that some of Jesus' contemporaries, some of his family and friends as well as his foes, regarded him as an alien. But that these contemporary judgments passed upon Jesus are correct is quite a different question which can be answered only by our study as a whole."
January 1, 1970
https://en.wikiquote.org/wiki/Mental_health_of_Jesus