"The account of the doctrine given by Plato is... in accordance with the view that it was of medical origin. Simmias says: "Our body being... strung and held together by the warm and the cold, the dry and the moist... [etc.,] our soul is a sort of temperament and attunement of these, when... mingled... well and in due proportion. If, then, our soul is an attunement,... when the body has been relaxed or strung up out of measure by diseases and other ills, the soul must... perish at once." This is... an application of the theory of Alkmaion, and is in accordance with... the Sicilian school of medicine. It completes the evidence that the Pythagoreanism of the end of the fifth century was an adaptation of the old doctrine to the new principles introduced by Empedokles."