"Hesiod’s description of Pandora’s box reminds us that though we live in a world of danger, where infectious diseases continue to maim and kill millions, especially across the developing world, we are not without hope. Part of that hope is our ability as humans to bring mathematics, genomics, data science, statistics, and computational science to bear on this problem and call these altogether rather disparate disciplines into humanity’s service against disease. Infectious disease modeling is part of that wider story of hope."