"(11) On 6 May 2021, the Authority published a scientific opinion on the safety assessment of titanium dioxide (E 171) as a food additive... [F]ollowing the 2018 Guidance on nanotechnology, the opinion also takes into account, in addition to all new relevant data, the data on the potential of titanium dioxide nanoparticles published before 2016, that had not previously been identified as relevant for the 2016 re-evaluation. In its opinion the Authority indicated that, based on all the evidence available, a concern for genotoxicity could not be ruled out, and given the many uncertainties, it concluded that titanium dioxide (E 171) can no longer be considered safe when used as a food additive. ..."