"Harry Shearer – Scratchy, Mr. Burns, Rev. Lovejoy, Ned Flanders, Lenny, Skull, President Arnold Schwarzenegger, Kent Brockman, Principal Skinner, Dr. Hibbert, Smithers, Toll Booth Man, Guard, Otto, Kang"

"Tom Hanks – Himself"

"That trailer is running on 7000 screens this weekend, committing us to opening every place in the world on the same date, which means we'd better get started. ~ James L. Brooks"

"EPA, EPA! It's all come true."

"[Lisa has a girl talk with Marge about Colin] I still haven't told you the best part! He cares about the environment! No! I still haven't told you the best part! He's got an [with a heavy Irish accent] Irish brogue! [In normal voice] No, wait, I still haven't told you the best part! He's not imaginary!"

"People! I have an important announcement. I have been working on a new acid-firing super-drill that can cut through anything. [pointing] It's right there...just outside of the dome."

"Hank Azaria – Professor Frink, Comic Book Guy, Moe Szyslak, Chief Wiggum, Lou, Carl, Cletus, Bumblebee Man, Male E.P.A Worker, Dome Depot Announcer, Kissing Cop, Carnival Barker, Counter Man, Apu, Dredrick Tatum, Sea Captain, E.P.A Passenger, Robot, Dr. Nick Riviera"

"Maggie Roswell – Helen Lovejoy"

"Joe Mantegna – Fat Tony"

"We've been running a little behind schedule, but only by about 15 years. ~ Matt Groening"

"The idea of the movie is that all of us who ran the show at one point, and who have been there from the beginning come together as the writing team for this movie. ~ James L. Brooks"

"Homer, you have to go out there, face that mob, and apologize for what you did."

"Okay, here it goes. Homer, I've always stood up for you. When people point out your flaws, I always say, "Well, sometimes you have to stand back to appreciate a work of art.""

"Eh, just passing the time."

"[poking mutant squirrel's eyes] Jab him-jab him-jab-jab-jab!"

"You ever tried going mad without power? It's boring. No one listens to you."

"[Springfield has been trapped inside a dome]"

"Dan Castellaneta – Homer Simpson, Itchy, Barney, Grampa, Stage Manager, Krusty the Clown, Mayor Quimby, Mayor's Aide, Multi-Eyed Squirrel, Panicky Man, Sideshow Mel, Mr. Teeny, E.P.A Official, Kissing Cop, Bear, Boy on Phone, NSA Worker, Officer, Santa's Little Helper, Squeaky-Voiced Teen, Groundskeeper Willie"

"Yeardley Smith – Lisa Simpson"

"Karl Wiedergott – Man, E.P.A Driver"

"Russi Taylor – Martin Prince"

"Phil Rosenthal – TV Dad"

"Billie Joe Armstrong Tré Cool Mike Dirnt – Green Day"

"We're very excited about the performances in this movie. Come next Oscars, we think it's going to be Milhouse's night. ~ Matt Groening"

"Since 2001 we had been working to get a script that would be worthy of people actually paying to see the Simpsons. ~ Matt Groening"

"If I were feeling any more pressure, I'd be a diamond. ~ Al Jean"

"We're going to put some fake plots out there just to make things interesting. ~ James L. Brooks"

"[whips dogs while using them for dog-sledding] Run! Run! Run! Run! Run! Run! [jumps from one slope to the other side] Jump! Jump! Land! Land! [while dogs rest] Rest! Rest! [while dogs running again] Run! Run! [after stopping for the night] Now I know we've had a rough day, but I'm sure we can put all that behind us and just- [the dogs maul him] That's my whipping arm! [the dogs abandon him] Oh, why does everything I whip leave me?"

"[sings while playing with his pig]"

"What's the point of going to church every Sunday if when someone we love has a genuine religious experience we ignore it? Right, Grampa?"

"[watching ad] That's where Springfield is!"

"You know, we are on the roof. We could have some fun."

"Wait! But if you kill my dad, you'll never know where the treasure is buried!"

"Dad, in case I don't make it, I'm sorry I said I wish you weren't my dad."

"But if they see you helping us, they'll kill you."

"Pollution in Springfield has reached crisis levels."

"That's why I've narrowed your choices down to five unthinkable options."

"I was tricked by an idiot!"

"So...you want some of my electricity, do you? Well, for once the rich white man is in control! I have two buttons behind this desk: one will supply your town with power, the other releases the hounds. Reach me. Make me your brother."

"See Our Family, And Feel Better About Yours."

"For Years, Lines Have Been Drawn...And Then Colored In Yellow."

"Julie Kavner – Marge Simpson, Selma Bouvier, Patty Bouvier"

"Nancy Cartwright – Bart Simpson, Maggie Simpson, Ralph Wiggum, Nelson Muntz, Todd Flanders, TV Daughter, Woman on Phone"

"Tress MacNeille – Sweet Old Lady, Colin, Agnes Skinner, Nelson's Mother, Pig, Crazy Cat Lady, Female E.P.A Worker, G.P.S. Woman, Cookie Kwan, Lindsey Naegle, TV Son, Medicine Woman, Girl on Phone"

"A. Brooks – Russ Cargill"

"Marcia Wallace – Mrs. Krabappel"

"This was enormously challenging, because it involved filling 120 blank pages with an actual story and words people say. ~ James L. Brooks"